Stress-induced hypertension in the borderline hypertensive rat: Stimulus duration

Hatton, Deborah D.; DeMerritt, Jamie; Coste, Sarah C.; McCarron, David A.

doi:10.1016/0031-9384(93)90167-e

Cited by 18 publications

(9 citation statements)

References 16 publications

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“…The tail-cuff method was used in all these studies to determine arterial pressure and, in two studies, arterial pressure was further measured at the end of stress period directly using catheters implanted in the aorta. 52,60 Although the authors did not emphasize this, it is quite evident that these direct measurements provided substantially lower hypertensive values compared with the tail-cuff method (see Table 1). In accordance with this, Mansi and Drolet 62 reported hypertension of only 6 mmHg after direct measures were taken at the end of 8 weeks restraint ⁄ airjet stress in BHR.…”

Section: Animal Models Of Psychogenic Hypertensionmentioning

confidence: 94%

“…The BHR were used in several later experiments with less complex stressors, such as inescapable footshocks, 52 restraint with airjet 60 or crowding, 61 all producing variable pressor effects (10–30 mmHg). The tail‐cuff method was used in all these studies to determine arterial pressure and, in two studies, arterial pressure was further measured at the end of stress period directly using catheters implanted in the aorta 52,60 . Although the authors did not emphasize this, it is quite evident that these direct measurements provided substantially lower hypertensive values compared with the tail‐cuff method (see Table 1).…”

Section: Psychogenic Hypertensionmentioning

confidence: 99%

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Animal models of psychogenic cardiovascular disorders: what we can learn from them and what we cannot

Nalivaiko

2011

Clin Exp Pharma Physio

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1. Epidemiological and clinical studies from the past 50 years provide unequivocal evidence for a close association and causative links between psychological stresses and cardiovascular dysfunction in humans. Not surprisingly, numerous animal experiments have been undertaken in an attempt to clarify underlying pathophysiological mechanisms. The present review focuses on animal models that provide insight into the mechanisms of stress-induced cardiovascular dysfunction. 2. Great success was achieved in elucidating the neural pathways and neurotransmitters responsible for the cardiac consequences of acute stressors, such as stress-induced ventricular arrhythmias and stress cardiomyopathy. These disturbances were reproduced successfully in canine and rodent models. The most important finding from these animal models is that these disturbances are mediated by elevated sympathetic outflow to the ventricular myocardium. 3. In contrast, attempts to induce psychogenic hypertension in rodents produced inconsistent and contentious results. More recent studies using biotelemetry raised serious doubts regarding the validity of earlier results obtained with the tail-cuff method and it remains unclear whether chronic stress can lead to sustained hypertension in animal models.

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Section: Animal Models Of Psychogenic Hypertensionmentioning

confidence: 94%

Section: Psychogenic Hypertensionmentioning

confidence: 99%

Animal models of psychogenic cardiovascular disorders: what we can learn from them and what we cannot

Nalivaiko

2011

Clin Exp Pharma Physio

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“…One of the objectives of this project, results of which will be reported here for females and elsewhere for males (30) is to examine the cardiovascular consequence; we thus elected to use a Wistar-derived strain of rats that is genetically susceptible to hypertension triggered by environmental stress (20). Borderline hypertensive rats (BHR) were produced by mating female rats of the Wistar strain with spontaneously hypertensive (SHR) males.…”

mentioning

confidence: 99%

Effect of high-fat diet during gestation, lactation, or postweaning on physiological and behavioral indexes in borderline hypertensive rats

Mitra¹,

Alvers²,

Crump³

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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Mitra A, Alvers KM, Crump EM, Rowland NE. Effect of high-fat diet during gestation, lactation, or postweaning on physiological and behavioral indexes in borderline hypertensive rats. Am J Physiol Regul Integr Comp Physiol 296: R20 -R28, 2009. First published October 29, 2008 doi:10.1152/ajpregu.90553.2008.-Maternal obesity is becoming more prevalent. We used borderline hypertensive rats (BHR) to investigate whether a high-fat diet at different stages of development has adverse programming consequences on metabolic parameters and blood pressure. Wistar dams were fed a high-or low-fat diet for 6 wk before mating with spontaneously hypertensive males and during the ensuing pregnancy. At birth, litters were fostered to a dam from the same diet group as during gestation or to the alternate diet condition. Female offspring were weaned on either control or "junk food" diets until about 6 mo of age. Rats fed the high-fat junk food diet were hyperphagic relative to their chow-fed controls. The junk food-fed rats were significantly heavier and had greater fat pad mass than those rats maintained on chow alone. Importantly, those rats suckled by high-fat dams had heavier fat pads than those suckled by control diet dams. Fasting serum leptin and insulin levels differed as a function of the gestational, lactational, and postweaning diet histories. Rats gestated in, or suckled by high-fat dams, or maintained on the junk food diet were hyperleptinemic compared with their respective controls. Indirect blood pressure did not differ as a function of postweaning diet, but rats gestated in the high-fat dams had lower mean arterial blood pressures than those gestated in the control diet dams. The postweaning dietary history affected food-motivated behavior; junk food-fed rats earned less food pellets on fixed (FR) and progressive (PR) ratio cost schedules than chow-fed controls. In conclusion, the effects of maternal high-fat diet during gestation or lactation were mostly small and transient. The postweaning effects of junk food diet were evident on the majority of the parameters measured, including body weight, fat pad mass, serum leptin and insulin levels, and operant performance. developmental programming; blood pressure; metabolic syndrome; motivation and Nutrition Examination Survey (NHANES III) found that Ͼ50% of nonpregnant women of child-bearing age (20 -39 yr of age) in the United States of America were overweight or obese (body mass index Ͼ25 kg/m 2 ), and Ͼ30% of girls between the ages of 12-19 were either at risk of being overweight or were overweight (22). These statistics imply that almost half of all babies are born to mothers who are either overweight or obese during pregnancy, and this fraction is likely to increase in the future.Adverse effects of obesity on mothers have been wellstudied; these include gestational diabetes, preeclampsia, prolonged delivery, and delayed wound healing postdelivery, all of which significantly increase health care costs (18). Babies born to obese women have a higher incidence of cong...

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“…The COLD induced fall in the superior mesenteric artery blood flow and the increase in the mesenteric vascular resistance was either reduced or eliminated by BIBP3226. Chronic cold stress (4°C, 1-3 weeks) has been shown to produce hypertension in rats [97,98]. We observed that chronic cold stress (4°C) produced a sustained increase in mean arterial pressure in both normotensive and borderline hypertensive rats (BHR) [99].…”

Section: Role Of Npy In Stress Induced Hypertensionmentioning

confidence: 86%

Neuropeptide Y and sympathetic control of vascular tone in hypertension

Westfall

Experientia Supplementum

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Stress-induced hypertension in the borderline hypertensive rat: Stimulus duration

Cited by 18 publications

References 16 publications

Animal models of psychogenic cardiovascular disorders: what we can learn from them and what we cannot

Animal models of psychogenic cardiovascular disorders: what we can learn from them and what we cannot

Effect of high-fat diet during gestation, lactation, or postweaning on physiological and behavioral indexes in borderline hypertensive rats

Neuropeptide Y and sympathetic control of vascular tone in hypertension

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