Stress-Induced Hyperglycemia: Consequences and Management

Vedantam, Deepanjali; Poman, Devyani S; Motwani, Lakshya; Asif, Nailah; Patel, Apurva; Anne, Krishna Kishore

doi:10.7759/cureus.26714

Cited by 39 publications

(37 citation statements)

References 90 publications

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“…Stress hyperglycaemia remains a major health emergency issue in our clinical pratice especially in hospital intensive care unit, affecting hundreds of millions of people worldwide [26]. It is reported that infection such as COVID-19 significantly increased rate of new-onset hyperglycaemia.…”

Section: Discussionmentioning

confidence: 99%

Profiling of circulating serum exosomal microRNAs in elderly patients with infectious stress hyperglycaemia

Zeng

He²,

Lv³

et al. 2023

Preprint

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Early diagnosis of hospitalized elderly patients with infectious stress hyperglycaemia (ISH) is clinically important, as without timely prevention and effective treatment, it is likely to deteriorate into septic shock, which significantly worsen patients’ survival rate. Systematic screening of specific biomarkers of serum small extracellular vesicles (sEVs) from ISH patient has not yet been reported. In this study, serum sEVs were derived from 10 elderly patients with ISH and 5 control patients with disease-match without hyperlycemia (non-ISH). RNA sequencing identified a total number of 49 sEVs enriched fraction derived miRNAs with differential expression between ISH and control group. Of which, top 22 miRNAs ranked by sensitivity × specificity were chosen for further research. Moreover,7 out of 22 miRNAs that related to glucose metabolism or immune disorder, were picked up for further validation in an independent cohort consisting of 52 participants (31 ISH and 21 non-ISH). A validation analysis revealed that 3 miRNAs (hsa-miR-21-5p，hsa-miR-335-5p，hsa-miR-28-3p) were statistically up-regulated in exosomes from ISH patients. In the validation cohort and discovery cohort, the AUC of 3 individual miRNAs ranged from 0.73 to 0.88. A logistic model combining three miRNAs achieved an AUC of 0.96. Besides,sEV‐miRNA‐based signatures effectively characterized patients’ poor clinical outcome. Survival curve analysis showed that miR-335-5p, miR-28-3p but not miR-21-5p, were significantly closely related to mortality, and the combination of the three could also predict patients outcome.(P<0.05).This study depicted the circulating exosomal miRNAs change in ISH patient and which could be used as a promising biomarker to detect ISH at an early stage, and predict patients clinical outcome.

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Section: Discussionmentioning

confidence: 99%

Profiling of circulating serum exosomal microRNAs in elderly patients with infectious stress hyperglycaemia

Zeng

He²,

Lv³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The Colubridae's high metabolic rates corroborate the blood glucose index to be significantly dependent on the feeding interval only in the studied snakes of this family 22 . A possible reason is a stress-induced hyperglycemia, once cortisol and catecholamines disturb glucose homeostasis, causing insulin resistance and increased gluconeogenesis 29 .…”

Section: Discussionmentioning

confidence: 99%

Alternative therapy improves hematological profiles of captive snakes from northeastern Brazil

Martins¹,

Braga

2023

J Health Biol Sci.

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ResumoObjetivo: Avaliar a influência de banhos de sol e de imersão em água nos perfis hematológicos de serpentes cativas, antes e após a aplicação deste tratamento alternativo. Metodologia: Serpentes cativas no NUROF-UFC foram submetidas à avaliação clínica e hematológica, depois submetidas ao tratamento alternativo por cinco semanas, sendo novamente avaliadas após. Os dados obtidos foram submetidos à análise estatística multivariada (NPMANOVA e GLM) para investigação de possíveis relações causais entre o tratamento e os perfis hematológicos. Resultados: Foi observada diferença significativa entre os eritrogramas e leucogramas nas três famílias de serpentes avaliadas antes e após o tratamento. Ressalta-se a redução significativa na razão heterófilos:linfócitos na Família Colubridae após o tratamento. Discussão: A diferença estatística deveu-se provavelmente à redução nos níveis de estresse, possibilitada por aquecimento e aumento de conversão da vitamina D durante a exposição solar; reidratação oral e refrescância nos banhos de imersão, e ao recondicionamento pelo exercício físico. Conclusão: Os resultados confirmaram a hipótese inicial, admitindo que um tratamento alternativo, simples mas aplicado sistematicamente, que incluiu exposição à luz solar e hidratação por imersão em água foi eficiente em reduzir as taxas de estresse em serpentes cativas.

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“…3 Stress hyperglycaemia remains a major health emergency issue in our clinical practice especially in-hospital ICU, affecting hundreds of millions of people worldwide. 40 It is reported that infection such as COVID-19 significantly increased rate of new-onset hyperglycaemia. Surprisingly, 46% of COVID-19 patients showed hyperglycaemia during hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Profiling of circulating serum exosomal microRNAs in elderly patients with infectious stress hyperglycaemia

Zeng

Lv³

et al. 2023

Clinical and Translational Dis

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BackgroundEarly diagnosis of hospitalized elderly patients with infectious stress hyperglycaemia (ISH) is clinically important, especially under the global coronavirus disease 2019 (COVID‐19) pandemic, as without timely prevention and effective treatment, it is likely to deteriorate into septic shock, thus worsening patient survival and complications. Moreover, cumulative studies have showed that patients with COVID‐19 are reported to have a greater prevalence of hyperglycaemia. However, the underlying mechanism remained unknown.Aim and methodSystematic screening of specific biomarkers of serum exosome‐derived microRNAs (sE‐miRNAs) from ISH patient has not yet been reported. In this study, sE‐miRNAs were derived from 10 elderly patients with ISH and 5 control patients with disease‐match without hyperglycaemia (non‐ISH). RNA sequencing identified that a total number of 49 sE‐miRNAs with differential expression between ISH and control group. Of which, top 22 miRNAs ranked by sensitivity × specificity were chosen for further research. Moreover, 7 out of 22 miRNAs that related to glucose metabolism or immune disorder were picked up for further validation in an independent cohort consisting of 52 participants (31 ISH and 21 non‐ISH).ResultA validation analysis revealed that three miRNAs (hsa‐miR‐21‐5p, hsa‐miR‐335‐5p and hsa‐miR‐28‐3p) were statistically up‐regulated in exosomes from ISH patients. In the validation cohort and discovery cohort, the AUC of three individual miRNAs ranged from 0.73 to 0.88. A logistic model combining three miRNAs achieved an AUC of 0.96. Besides, sE‐miRNAs‐based signatures effectively characterized patients' poor clinical outcome. Survival curve analysis showed that hsa‐miR‐335‐5p, hsa‐miR‐28‐3p but not hsa‐miR‐21‐5p, were significantly closely related to mortality, and the combination of these three miRNAs could also predict patients outcome (p < .05).ConclusionThis study depicted the circulating exosomal miRNAs change in ISH patient, which could be used as a promising biomarker to detect ISH at an early stage and predict patients clinical outcome.

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Stress-Induced Hyperglycemia: Consequences and Management

Cited by 39 publications

References 90 publications

Profiling of circulating serum exosomal microRNAs in elderly patients with infectious stress hyperglycaemia

Profiling of circulating serum exosomal microRNAs in elderly patients with infectious stress hyperglycaemia

Alternative therapy improves hematological profiles of captive snakes from northeastern Brazil

Profiling of circulating serum exosomal microRNAs in elderly patients with infectious stress hyperglycaemia

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