2005
DOI: 10.1073/pnas.0501650102
|View full text |Cite
|
Sign up to set email alerts
|

Stress-induced enhancement of leukocyte trafficking into sites of surgery or immune activation

Abstract: Effective immunoprotection requires rapid recruitment of leukocytes into sites of surgery, wounding, infection, or vaccination. In contrast to immunosuppressive chronic stressors, short-term acute stressors have immunoenhancing effects. Here, we quantify leukocyte infiltration within a surgical sponge to elucidate the kinetics, magnitude, subpopulation, and chemoattractant specificity of an acute stress-induced increase in leukocyte trafficking to a site of immune activation. Mice acutely stressed before spong… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

5
161
1
4

Year Published

2006
2006
2022
2022

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 209 publications
(171 citation statements)
references
References 54 publications
5
161
1
4
Order By: Relevance
“…Regulatory T cells expressing CTLA-4 can induce dendritic cells to express indoleamine 2,3-dioxygenase (IDO) by interacting with its ligand CD80-CD86, thereby promoting maternal tolerance of the fetal allograft (47). Regardless of lymphoid cell number, pregnancy-associated immunosuppression has been linked with impaired IL-15 signaling, which uses the intermediate, JAK3 (48). Failure to generate an effective regulatory T cell can result in the loss or absence of maternal tolerance, potentially leading to pregnancy loss (47).…”
Section: Figurementioning
confidence: 99%
“…Regulatory T cells expressing CTLA-4 can induce dendritic cells to express indoleamine 2,3-dioxygenase (IDO) by interacting with its ligand CD80-CD86, thereby promoting maternal tolerance of the fetal allograft (47). Regardless of lymphoid cell number, pregnancy-associated immunosuppression has been linked with impaired IL-15 signaling, which uses the intermediate, JAK3 (48). Failure to generate an effective regulatory T cell can result in the loss or absence of maternal tolerance, potentially leading to pregnancy loss (47).…”
Section: Figurementioning
confidence: 99%
“…On the other hand, Dhabhar et al (1995) reported that stress reduced significantly numbers and percentages of lymphocytes by an increase in numbers and percentages of neutrophils. Also, corticosteroids and catecholamine-induced increased accumulation of lymphocytes in the spleen, lymph nodes and mucosal sites which decrease in lymphocytes in the blood (Viswanathan and Dhabhar, 2005). In contrast, some studies have shown that stress increased blood WBCs numbers in rats (Harris et al, 1995) and humans (Bosch et al, 2003).…”
Section: Discussionmentioning
confidence: 93%
“…However, a closer look reveals that neutrophil proliferation and survival are enhanced by GCs (Cox 1995;Liles et al 1995) and that the largescale depletion of other leukocytes may actually reflect extravasation to a site of injury, rather than cell death (Dhabhar et al 1996;Dhabhar and McEwen 1997;Viswanathan and Dhabhar 2005). The depletion of circulating leukocytes by GCs has been described metaphorically as a deployment of immune soldiers to the battlefront rather than to the barracks .…”
Section: The Pro-inflammatory Effects Of Gcs Outside the Nervous Systemmentioning
confidence: 99%