Stress-induced dysfunction of neurovascular astrocytes contributes to sex-specific behavioral deficits
Justin L. Bollinger,
Shobha Johnsamuel,
Lauren L. Vollmer
et al.
Abstract:Astrocytes form an integral component of the neurovascular unit, ensheathing brain blood vessels with projections high in aquaporin-4 (AQP4) expression. These AQP4-rich projections facilitate interaction between the vascular endothelium, astrocytes, and neurons, and help stabilize vascular morphology. Studies using preclinical models of psychological stress and post-mortem tissue from patients with major depressive disorder (MDD) have reported reductions in AQP4, loss of astrocytic structures, and vascular imp… Show more
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