Stress induced cortisol release and schizotypy

Walter, Emma E.; Fernández, Francisco Sousa; Snelling, Mollie; Barkus, Emma

doi:10.1016/j.psyneuen.2018.01.012

Cited by 22 publications

(28 citation statements)

References 47 publications

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“…In addition to LH and FSH, the cortisone level also increased after the ovary removal, especially in the face of stressful situations. Consistent with our reports, abnormal cortisone release following stress has been reported ( 30 ). ACTH and cortisone, which are part of HPA axis (Hypothalamus-pituitary-adrenal axis) are stressful hormones ( 30 ).…”

Section: Discussionsupporting

confidence: 93%

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Stress Induced Hormone and Neuromodulator Changes in Menopausal Depressive Rats

Jing

Yang

et al. 2018

Front. Psychiatry

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Objective: Previously, we showed that neuromodulators are important factors involved in depression, here we aim to further investigate the interactions between neuromodulators and sex hormone involved in menopause related depression in rats.Methods: Menopausal depression was made with bilateral ovariectomies in female SD rats followed by chronic mild unpredictable stress treatment for 21 days. Thirty six rats were randomly divided into four groups: sham surgery group, sham/stress group, surgery group, surgery/stress group. Then open-field locomotor scores and sucrose intake were employed to observe behavior changes. The levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT) in the cerebral spinal fluid and serum adrenocorticotropic hormone (ACTH), cortisone were determined with High-performance liquid chromatography (HPLC). Serum estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured with radioimmunoassay.Results: The open-field locomotor scores and sucrose intake were significantly decreased after the surgery and stress treatment (p < 0.01). The Serum E2 level decreased significantly after the surgery (p < 0.01), but serum LH, FSH levels increased significantly in the surgery group than the sham surgery group (p < 0.01). The cortisone levels increased significantly in sham/stress group than that in the sham surgery group during the first 2 weeks at stressful treatment, but decrease afterwards. The monoamine levels in the surgery/stress group were much lower than those in the sham surgery group (p < 0.01). The correlation analysis found that LH and FSH are related more to the neurotransmitter release than E2.Conclusion: Ovary removal rats showed depression-like behaviors, with LH and FSH increase and monoamine decrease, and the levels of these monoamines in the stress treated groups changed only after the stressful treatment. The LH, FSH hormone increasing might be the reason for the lower monoamine release, which in turn might be the reason for depressed syndromes in the menopause. The cortisone and ACTH in the serum in the surgery/stress group were much higher than that in the sham surgery group.

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Section: Discussionsupporting

confidence: 93%

“…Consistent with our reports, abnormal cortisone release following stress has been reported ( 30 ). ACTH and cortisone, which are part of HPA axis (Hypothalamus-pituitary-adrenal axis) are stressful hormones ( 30 ). The positive correlation between LH and FSH together with cortisone and ACTH suggests that LH and FSH are related to stress.…”

Section: Discussionsupporting

confidence: 93%

Stress Induced Hormone and Neuromodulator Changes in Menopausal Depressive Rats

Jing

Yang

et al. 2018

Front. Psychiatry

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“…Indeed, two subsequent studies which used the same protocol for obtaining cortisol samples in the home environment as Mondelli and colleagues found no significant associations between life events and diurnal cortisol in any group (31,51), which is particularly surprising given that that the latter employed the same life event measure and included FEP patients (51). Our findings contrast with those observed in studies examining cortisol responses to acute psychosocial stressor tasks, in which healthy controls show a robust cortisol response whilst patients with psychosis and schizophrenia (37)(38)(39) and those at high-risk for psychosis (74,75) demonstrate a blunted cortisol response. Together, these findings suggest that the cortisol abnormalities previously observed among psychosis spectrum groups (e.g., elevated basal and diurnal cortisol and a blunted CAR) are unlikely to be driven by greater exposure and/or sensitivity to these psychosocial stressors (which do not appear to elicit a robust cortisol response).…”

Section: Discussioncontrasting

confidence: 99%

Cortisol Responses to Naturally Occurring Psychosocial Stressors Across the Psychosis Spectrum: A Systematic Review and Meta-Analysis

et al. 2020

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healthy controls and psychosis spectrum groups were observed for only one of the six stressor-cortisol pairings examined, where life event exposure and diurnal cortisol were positively correlated in controls [r=0.25 (95% CI: 0.01 to 0.46)], but negatively correlated in the psychosis spectrum group [r=-0.28 (95% CI:-0.49 to-0.04)]. Conclusions: Overall, we observed poor concordance between naturally-occurring psychosocial stressors and cortisol irrespective of stressor type, cortisol measure, or group status. We consider a range of methodological factors that may have obscured the ability to detect "true" associations and provide recommendations for future studies in this field.

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“…The stress response will stimulate the hypothalamus‐pituitary‐adrenal axis (HPAA), which activates the release of adrenocorticotropic hormone (ACTH). ACTH stimulates the adrenal gland to increase the secretion of stress response hormones, including glucocorticol, which in turn has the largest amount of cortisone and can significantly affect the immune response, metabolism, cardiovascular function, thyroid function, and confrontation pressure . Noninvasive heart rate variability (HRV) is an indicator of the total activity of the autonomic nervous system.…”

Section: Introductionmentioning

confidence: 99%

Relationship between heart rate variability and aggressive behavior among patients with schizophrenia hospitalized in acute wards

Wang

Yang

Chen

et al. 2020

Perspect Psychiatr Care

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Purpose: To explore the state of mental treatment, heart rate variability (HRV), level of aggressive behavior, and their relationships among hospitalized patients with schizophrenia.Design and Methods: This study adopted a follow-up design and convenience sampling. Thirty-three subjects completed the questionnaire, and their HRV indices were measured.Findings: Patients' psychiatric symptoms showed a significant downward trend after hospitalization (P = .003). The standard deviation of the normal-to-normal intervals in the morning was significantly correlated with overall aggression, physical aggression, and verbal aggression.Practice Implications: HRV can be regularly monitored among inpatients with schizophrenia with a risk of high aggression as an indicator of possible aggressive behavior. K E Y W O R D Sacute ward, aggressive behavior, heart rate variability, schizophrenia

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Stress induced cortisol release and schizotypy

Cited by 22 publications

References 47 publications

Stress Induced Hormone and Neuromodulator Changes in Menopausal Depressive Rats

Stress Induced Hormone and Neuromodulator Changes in Menopausal Depressive Rats

Cortisol Responses to Naturally Occurring Psychosocial Stressors Across the Psychosis Spectrum: A Systematic Review and Meta-Analysis

Relationship between heart rate variability and aggressive behavior among patients with schizophrenia hospitalized in acute wards

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