Stress-induced change in serum BDNF is related to quantitative family history of alcohol use disorder and age at first alcohol use

Sharma, Shobhit; Graham, Reiko; Rohde, Rodney E.; Ceballos, Natalie A.

doi:10.1016/j.pbb.2016.12.002

Cited by 11 publications

(7 citation statements)

References 47 publications

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“…Likewise, acute physical exercise is a reliable trigger of serum BDNF release [22]. However, a recent study found a post-stress decrease in serum BDNF levels in a mixed-sex sample of 68 young adults [26]. Besides differences in sample size and characteristics, we attribute these conflicting results to methodical discrepancies between studies, particularly regarding the utilized stressinductions.…”

Section: Discussionmentioning

confidence: 93%

“…Besides differences in sample size and characteristics, we attribute these conflicting results to methodical discrepancies between studies, particularly regarding the utilized stressinductions. While both our and Meng's study [25] employed a classical psychosocial stress task, the TSST [24], Sharma et al [26] employed a combination of psychosocial and physical stressor. Although the paradigm used in the latter study was of considerable duration (30 min), it may have lacked the necessary strength to elicit a substantial stress response, which is conventionally affirmed by a cortisol surge of at least 1.5 nmol/l from baseline [57].…”

Section: Discussionmentioning

confidence: 94%

“…However, evidence for an effect of psychosocial stress is scarce and inconclusive. The few studies investigating levels of serum BDNF in response to psychosocial stress used varying stress inductions in small and selective samples and have produced conflicting results: While one study found increased serum BDNF levels following psychosocial stress (Trier Social Stress Test; TSST [24]) [25], decreased serum BDNF levels were reported following a paradigm combining psychological and physical stressors [26].…”

Section: Introductionmentioning

confidence: 99%

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Acute psychosocial stress increases serum BDNF levels: an antagonistic relation to cortisol but no group differences after mental training

Linz

Puhlmann

Apostolakou

et al. 2019

Neuropsychopharmacol.

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Brain-derived neurotrophic factor (BDNF) is an essential facilitator of neuronal plasticity. By counteracting the adverse effects of excessive stress-induced glucocorticoid signaling, BDNF has been implicated as a resilience factor to psychopathology caused by chronic stress. Insights into the effects of acute stress on peripheral BDNF levels in humans are inconclusive. The short-term interplay between BDNF and cortisol in response to acute psychosocial stress remains unexplored. Furthermore, it is unknown whether mental training that is effective at reducing cortisol reactivity can also influence BDNF during acute stress. In the current study, we investigated serum BDNF levels during an acute psychosocial stress paradigm, the Trier Social Stress Test (TSST), in 301 healthy participants (178 women, mean age = 40.65) recruited as part of the ReSource Project, a large-scale mental training study consisting of three distinct 3-month training modules. Using a cross-sectional study design, we first examined the relationship between BDNF and salivary cortisol in a control group with no mental training. Subsequent analyses focused on differences in BDNF stress levels between control and mental training groups. We show that serum BDNF is indeed stress-sensitive, characterized by a significant post-stress increase and subsequent decline to recovery. While respective increases in BDNF and cortisol were not associated, we found two indications for an antagonistic relationship. Higher BDNF peaks after stress were associated with steeper cortisol recovery. On the other hand, the magnitude of the cortisol stress response was linked to steeper BDNF recovery after stress. BDNF levels were not modulated by any of the mental training modules. Providing novel evidence for the dynamics of BDNF and cortisol during acute stress, our findings may further inform research on the physiological mechanisms involved in stress chronification and the associated health risks.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute psychosocial stress increases serum BDNF levels: an antagonistic relation to cortisol but no group differences after mental training

Linz

Puhlmann

Apostolakou

et al. 2019

Neuropsychopharmacol.

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show abstract

“…Peripheral biomarkers might shed light on shared biological abnormalities in AUD and depression. For instance, brainderived neurotrophic factor (BDNF) has been proposed to play a major role in the pathophysiology of depression, and has also been related to AUD (8,9). According to the neurotrophin hypothesis, stress might decrease BDNF levels, which could lead to decreased neuronal plasticity, resulting in depression (10).…”

Section: Introductionmentioning

confidence: 99%

Exploring Brain Derived Neurotrophic Factor and Cell Adhesion Molecules as Biomarkers for the Transdiagnostic Symptom Anhedonia in Alcohol Use Disorder and Comorbid Depression

et al. 2020

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Background: Alcohol Use Disorder (AUD) and depressive disorder often co-exist and have a shared heritability. This study aimed to investigate Brain-Derived Neurotrophic Factor (BDNF) and three Cell Adhesion Molecules (CAMs) as transdiagnostic biomarkers in AUD and depression co-morbidity. Methods: In a cross-sectional study, patients with AUD (n=22), AUD and depression (n=19), and healthy controls (n=20) were examined. Depression and anxiety severity were assessed using the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale. Anhedonia, alcohol use and dependence, craving, and social adaptation were assessed through self-report questionnaires. BDNF and CAM concentrations in peripheral serum were measured after overnight fasting using a Luminex assay. After controlling for age and gender, biomarker levels were compared across groups. The association between biomarker concentrations and symptom severity scales were explored using correlation and multiple regression analyses. Results: BDNF and Neuronal CAM were lower in patients with AUD with and without depression compared to healthy controls. No differences were observed for Vascular CAM-1 and Interstitial CAM-1. BDNF correlated negatively with anhedonia levels. BDNF, age and gender together explained 21% of variability in anhedonia levels. Conclusion: This pilot study suggests that peripheral levels of BDNF and NCAM might be reduced in AUD with and without comorbid mood disorder. Since low BDNF levels were

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“…33 In the context of stress-related alcohol consumption history, it is evident that acute stress decreased serum BDNF with the quantitative family history of alcohol use disorder (qFH) and age at first alcohol use in combination accounting for 15% of the variance in serum BDNF concentrations. 34 Following a 12-week regime of Yoga and Meditation based lifestyle intervention to intervene against stress and cellular ageing, it was observed that levels of total antioxidant capacity, telomerase activity β-endorphin, BDNF and sirtuin-1 were increased markedly and reactive oxygen species, 8-hydroxy-2'-deoxyguanosine and interlekin-6, oxidative stress and pro-inflammatory biomarkers, after the Yoga and Meditation based lifestyle episode. 35 Paired immunoglobulin-like receptor B is a functional receptor for myelin-associated inhibitory proteins that influences axon regeneration in injured brains.…”

Section: Editorialmentioning

confidence: 99%

BDNF Integrity in Ageing and Stress

Archer¹

2017

MOJGG

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Stress-induced change in serum BDNF is related to quantitative family history of alcohol use disorder and age at first alcohol use

Cited by 11 publications

References 47 publications

Acute psychosocial stress increases serum BDNF levels: an antagonistic relation to cortisol but no group differences after mental training

Acute psychosocial stress increases serum BDNF levels: an antagonistic relation to cortisol but no group differences after mental training

Exploring Brain Derived Neurotrophic Factor and Cell Adhesion Molecules as Biomarkers for the Transdiagnostic Symptom Anhedonia in Alcohol Use Disorder and Comorbid Depression

BDNF Integrity in Ageing and Stress

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