Stress, <i>COMT</i> Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study

Seib, Charrlotte; Whiteside, Eliza; Voisey, Joanne; Lee, Kathryn; Alexander, Kimberly; Humphreys, Janice; Chopin, Lisa K.; Anderson, Debra

doi:10.1089/gtmb.2015.0028

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…For COMT rs165774, the A allele is associated with lower COMT activity compared with the G allele [31]. In line with this view, the present results suggest that A-allele carriers may be more vulnerable to childhood adversity, as indicated by their higher levels of irrational beliefs (but see [43]). The polymorphism OXTR rs5357 has not been functionally characterized, but a previous candidate gene study found that childhood maltreatment was associated with depressive symptoms only in G-allele carriers [44].…”

Section: Discussionsupporting

confidence: 83%

Gene–Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes

Chiș,

Oltean,

Bîlc

et al. 2024

IJMS

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Cognitive behavioral therapy is based on the view that maladaptive thinking is the causal mechanism of mental disorders. While this view is supported by extensive evidence, very limited work has addressed the factors that contribute to the development of maladaptive thinking. The present study aimed to uncover interactions between childhood maltreatment and multiple genetic differences in irrational beliefs. Childhood maltreatment and irrational beliefs were assessed using multiple self-report instruments in a sample of healthy volunteers (N = 452). Eighteen single-nucleotide polymorphisms were genotyped in six candidate genes related to neurotransmitter function (COMT; SLC6A4; OXTR), neurotrophic factors (BDNF), and the hypothalamic–pituitary–adrenal axis (NR3C1; CRHR1). Gene–environment interactions (G×E) were first explored in models that employed one measure of childhood maltreatment and one measure of irrational beliefs. These effects were then followed up in models in which either the childhood maltreatment measure, the irrational belief measure, or both were substituted by parallel measures. Consistent results across models indicated that childhood maltreatment was positively associated with irrational beliefs, and these relations were significantly influenced by COMT rs165774 and OXTR rs53576. These results remain preliminary until independent replication, but they represent the best available evidence to date on G×E in a fundamental mechanism of psychopathology.

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Section: Discussionsupporting

confidence: 83%

Gene–Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes

Chiș,

Oltean,

Bîlc

et al. 2024

IJMS

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“…Lastly, allelic variations of the catechol-O-methyltransferase ( COMT ) gene, which is involved in the degradation of catecholamine neurotransmitters (i.e., dopamine, norepinephrine, and epinephrine), have effects on mood, emotion processing, and perception of well-being, as well as pain sensitivity across a number of populations (Belfer & Segall, 2011; Wichers et al, 2008). Even with relatively small sample sizes, research has shown trends for patients with the Val158Met (rs4680) COMT polymorphism to have increased risk for persistent postsurgical pain and incidence of depressive symptoms (Hickey et al, 2011; Seib et al, 2016). Recent data also suggest an interaction effect of BDNF signaling and COMT on human cortical plasticity at the cellular and behavioral levels of analysis (Witte et al, 2012).…”

mentioning

confidence: 99%

Variations in COMT and NTRK2 Influence Symptom Burden in Women Undergoing Breast Cancer Treatment

Young

Kelly

Shim

et al. 2017

Biological Research For Nursing

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Women with breast cancer frequently report distressing symptoms during and after treatment that can significantly erode quality of life (QOL). Symptom burden among women with breast cancer is of complex etiology and is likely influenced by disease, treatment, and environmental factors as well as individual genetic differences. The purpose of the present study was to examine the relationships between genetic polymorphisms within Neurotrophic tyrosine kinase receptor 1 (NTRK1), Neurotrophic tyrosine kinase receptor 2 (NTRK2), and catechol-O-methyltransferase (COMT) and patient symptom burden of QOL, pain, fatigue, anxiety, depression, and sleep disturbance before, during, and after treatment for breast cancer in a subset of participants (N = 51) in a randomized clinical trial of a novel symptom-management modality for women with breast cancer undergoing chemotherapy. Patients were recruited at the time of initial breast cancer diagnosis and completed all survey measures at the time of recruitment, after the initiation of treatment (surgery and/or chemotherapy), and then following treatment conclusion. Multiple linear regression analyses revealed significant associations between NTRK2 and COMT single nucleotide polymorphism (SNP) genotype and symptom burden. Two COMT variants were associated with the specific symptoms of anxiety and QOL measures prior to the initiation of chemotherapy as well as pain interference and severity during and after treatment. Genotype at the NTRK2 SNP rs1212171 was associated with both sleep disturbance and fatigue. These findings, while exploratory, indicate that the genotypes of NTRK2 and COMT may contribute to relative risk for symptom burden during and shortly after the period of chemotherapy in women with early stage breast cancer.

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“…Associations of rs165774 were also found by Higashiyama et al in patients with schizophrenia vs. healthy controls and by Seib et al in older women with depression. 29,30 Ittiwut et al found an association between rs4680 and c.615+1354C>T (rs174696) in European American patients with cocaine-induced paranoia. 31 In our current study we have investigated a possible existence of an association between rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, as well as rs174696 and levodopa-induced dyskinesia in 232 Caucasian PD patients from the neurological department of the Siberian State University Hospital of Tomsk, Russian Federation.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia

et al. 2018

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-Purpose. Parkinson's disease (PD), a common neurodegenerative disorder, is usually treated with Levodopa (L-DOPA). The use of this drug, however, is severely limited by the development of side effects of the motor system: Levodopa-induced dyskinesia (LID). The aim of this study is to investigate the association between seven COMT gene single-nucleotide polymorphisms (SNPs) and the development of LID in patients with PD. Methods. 232 Caucasian patients with PD were investigated. 212 patients with PD received Levodopa therapy. Dyskinesia was assessed with the use of the Abnormal Involuntary Movement Scale (AIMS). Genotyping was carried out on seven SNPs of the COMT gene (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) using a real-time PCR method, and blind to the clinical status of the subjects. Results. We found association between four SNPs, rs165774, rs4818, rs4633, rs4680, and LID. When the duration of disease was added as a covariate in regression analysis, however, the results did not reach statistical significance. Only the additive model for rs165774 was found to be close to be statistical significance ], permutation p = 0.057). Conclusions. The results failed to clearly support a contribution of the studied polymorphisms; this may be related to a dominant relationship with the disease duration confounding the effect on the prevalence of LID.

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Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study

Cited by 7 publications

References 17 publications

Gene–Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes

Gene–Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes

Variations in COMT and NTRK2 Influence Symptom Burden in Women Undergoing Breast Cancer Treatment

Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia

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