Stress hormonal changes in the brain and plasma after acute noise exposure in mice

Jin, Sang Gyun; Kim, Min Jung; Park, So Young; Park, Shi Nae

doi:10.1016/j.anl.2016.07.013

Cited by 12 publications

(12 citation statements)

References 18 publications

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“…Penelitian oleh Jin et al (2016) membahas tentang perubahan hormon pada tikus yang terpapar kebisingan akut dan memperoleh hasil terdapat peningkatan yang signifikan terhadap hormon norepinefrin (hormon stres) pada hippocampus tikus. 10 Sementara itu, penelitian Siswati dan Adriyani (2017) menyebutkan bahwa pada karyawan unit produksi PT. Industri Kemasan Semen Gresik (IKSG) dengan jumlah responden sebanyak 22 orang yang terpapar kebisingan rata-rata sebesar 90,8 dB(A) didapatkan hubungan yang signifikan antara kebisingan dengan kenaikan tekanan darah sistolik, diastolik, dan denyut nadi.…”

Section: Pendahuluanunclassified

“…14,15 Kebisingan akut dapat memicu kondisi stres yang akan mengaktivasi sistem saraf simpatis dengan cara memproduksi hormon epinefrin dan norepinefrin yang menyebabkan pembuluh darah menjadi vasokontriksi sehingga menaikkan cardiac output dan resistensi perifer. 10,16 Ketika kondisi tubuh kekurangan O2 (hipoksia), CO2 (hipokapnia), dan kadar asam yang tinggi (asidosis) dalam darah, terutama kondisi saat seseorang terpapar asap rokok maupun sedang merokok menyebabkan kemoreseptor pada badan aorta dan karotis menjadi aktif, sehingga akan mengirimkan impuls eksitatorik ke pusat kardiovaskular dan berakibat meningkatnya tekanan darah dan denyut nadi. 17,18 Faktor lingkungan yang sangat berpengaruh terhadap peningkatan tekanan darah dan denyut nadi adalah paparan kebisingan di tempat kerja.…”

Section: Pendahuluanunclassified

“…mengaktifkan sistem saraf simpatis dan menginduksi perubahan hormonal dalam tubuh yang diperankan oleh hypothalamic-pituitary-adrenal (HPA) axis. 10 Sistem saraf simpatis yang diaktifkan oleh hipotalamus menyebabkan produksi hormon epinefrin dan norepinefrin oleh medulla adrenal menjadi tinggi. Hal ini didukung oleh penelitian Jin et al (2016) yang menyatakan bahwa terdapat peningkatan yang signifikan terhadap kadar hormon norepinefrin pada tikus yang terpapar kebisingan akut (p=0,019).…”

Section: Hasil Dan Pembahasanunclassified

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Pengaruh Kebisingan Terhadap Tekanan Darah dan Nadi pada Pekerja Pabrik Kayu PT. Muroco Jember

Mukhlish

Sudarmanto

Hasan

2018

JKLI

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Latar belakang: Kebisingan merupakan bunyi yang memiliki intensitas di atas batas normal dan dapat mengganggu kesehatan pada orang yang terpapar. Paparan kebisingan terjadi dalam proses produksi pada industri pabrik kayu, sehingga pekerja menjadi pihak utama yang terdampak. Dampak yang terjadi utamanya pada sistem kardiovaskular. Penelitian ini bertujuan untuk menganalisis pengaruh kebisingan terhadap tekanan darah dan denyut nadi pada pekerja pabrik kayu PT. Muroco Jember. Metode: Penelitian ini berjenis analitik observasional dengan desain penelitian cross sectional. Responden penelitian berjumlah 24 orang yang diambil dengan teknik total sampling. Pengukuran kebisingan menggunakan alat sound level meter. Pengumpulan data karakteristik pekerja menggunakan kuesioner. Responden penelitian diukur sebelum dan setelah bekerja, dengan menggunakan sphygmomanometer air raksa untuk tekanan darah dan penghitungan manual denyut nadi pada arteri brachialis. Analisis data menggunakan uji komparasi paired t-test pada level signifikansi 5%. Hasil: Intensitas kebisingan dari 4 sektor kerja menunjukkan hasil yang beragam. Intensitas kebisingan terendah pada sektor produksi A yaitu 82,9 dB(A), sedangkan tertinggi pada sektor sawmill B yaitu 98,1 dB(A). Sebagian besar responden (66,7%) berusia 29-40 tahun dengan masa kerja responden (62,5%) kurang dari 2 tahun. Sebanyak 91,7% responden tidak memakai APT pada saat bekerja. Berdasarkan uji komparasi paired t-test, didapatkan pengaruh paparan kebisingan akut antara sebelum dan setelah bekerja terhadap tekanan darah sistolik (p= <0,001), diastolik (p=0,049), dan denyut nadi (p=0,020).Simpulan: Terdapat peningkatan yang signifikan terhadap tekanan darah sistolik, diastolik, denyut nadi antara sebelum dan setelah bekerja dalam paparan kebisingan akut pada pekerja pabrik kayu PT. Muroco Jember. Diperlukan penelitian dengan mengendalikan variabel lain yang mengganggu untuk kesempurnaan penelitian selanjutnya. ABSTRACT Title: The Effect of Noise on Blood Pressure and Pulse Rate in Workers at PT. Muroco Jember Wood FactoryBackground: Noise is a sound that has an intensity above the normal limit and may interfere with the health of the exposed person. Exposure to noise often occurs in the production process at the wood processing factory, so that workers become the main person affected. The impact mainly occurs in cardiovascular system. This study aims to analyze the effect of noise on blood pressure and pulse rate in workers at PT. Muroco Jember wood factory.Method: This is an observational analytic research with cross sectional design. The respondents amounted to 24 people taken with total sampling technique. The measurement of noise intensity was using sound level meter. Data collecting of worker characteristics was using questionnaires. Respondents were measured before and after work, using a mercury sphygmomanometer for blood pressure and manual palpation of pulse rate in the brachial artery. Data was analyzed with paired t-test comparative at 5% significance level.Result: The noise intensity of 4 sectors of the factory showed diverse results. The lowest noise intensity is in production sector A, 82.9 dB (A), while the highest is in sawmill B sector, 98.1 dB (A). Most of the respondents (66.7%) were 29-40 years old with respondents working period (62.5%) were less than 2 years. As many as 91.7% of respondents did not use ear protection device while working. Based on paired t-test, there was an effect of acute exposure between before and after working on systolic blood pressure (p < 0,001), diastolic (p = 0.049), and pulse rate (p = 0.020)Conclusion: There was a significant increase in systolic, diastolic blood pressure, and pulse rate between before and after work in an acute noise exposure in worker at PT. Muroco Jember wood factory. Further research is required by controlling other disturbing variables for a better research.

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Section: Pendahuluanunclassified

Section: Hasil Dan Pembahasanunclassified

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Pengaruh Kebisingan Terhadap Tekanan Darah dan Nadi pada Pekerja Pabrik Kayu PT. Muroco Jember

Mukhlish

Sudarmanto

Hasan

2018

JKLI

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“…Measurements of the levels of norepinephrine and cortisol in plasma were made according to a method described previously. 18…”

Section: Hplc Of Plasma Stress Hormonementioning

confidence: 99%

Evidence of Tinnitus Development Due to Stress: An Experimental Study in Rats

Kim

Park

et al. 2021

The Laryngoscope

Self Cite

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Objectives/Hypothesis: Tinnitus can develop due to, or be aggravated by, stress in a rat model. To investigate stress as a possible causal factor in the development of tinnitus, we designed an animal study that included tinnitus behavior and excitatory/inhibitory neurotransmitter expression after noise exposure as well as restraint stress.Study Design: An experimental animal study. Methods: Wistar rats were grouped according to single or double exposure to noise and restraint stress. The noise exposure (NE) group was subjected to 110 dB sound pressure level (SPL) of 16 kHz narrow-band noise (NBN) for 1 hour, and the restraint stress (RS) group was restrained for 1 hour with or without noise exposure. Gap prepulse inhibition of the acoustic startle (GPIAS) reflex was measured at an NBN of 16 kHz to investigate tinnitus development. Various immunohistopathologic and molecular biologic studies were undertaken to evaluate possible mechanisms of tinnitus development after noise and/or restraint stress.Results: The RS-only group showed a reduced GPIAS response, which is a reliable sign of tinnitus development. In the double-stimulus groups, more tinnitus-development signs of reduced GPIAS responses were observed. The expression of γ-aminobutyric acid A receptor α1 (GABAAR α1) in the hippocampus decreased in the NE│RS group. Increased N-methyl-Daspartate receptor1 intensities in the NE│RS group and decreased GABAAR α1 intensities in the RS and NE│RS groups were observed in the CA3 region of the hippocampus.Conclusions: Tinnitus appeared to develop after stress alone in this animal study. An imbalance in excitatory and inhibitory neurotransmitters in the hippocampus may be related to the development of tinnitus after acute NE and/or stress.

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“…Kebisingan direspon oleh otak sebagai ancaman yang berhubungan dengan pelepasan hormon stress seperti epinephrine (18). Paparan bising berintensitas tinggi dapat mengaktifkan sistem saraf sehingga memicu perubahan hormon yang diperankan oleh Hipothalamic Pituitary Adrenal axis (HPA) (19).…”

Section: Kegiatanunclassified

The Potential Risk of Hearing Loss on Noise-Exposed Housewives : An Observational Study at Sukosari Madiun Railway Residentia

Krisnanti

Sulistyorini

2020

JKL

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Introduction: Hearing loss events often occur in communities who exposed to high-intensity noise and for long periods. Residents who lived around the railway tracks had a high risk of experiencing hearing loss. This study aims to analyze the potential risk of hearing loss in housewives who for 1x24 hours was always exposed to train noise. Method: This research was an observational analytic study with a cross-sectional design. The sample of this study was 42 housewives who were divided into 2 groups: 21 people exposed to noise and 21 people not exposed to noise. Respondents were selected using a simple random sampling technique. Research data obtained through interviews and observations. Measurement of noise intensity using a whisper test. Result and Discussion: Measurement of day and night noise (L = 65,9 dBA) has exceeded the noise quality standard set for residential areas which were 55 dBA. The results showed that noise (p = 0,030; OR = 5,846) had a strong correlation with hearing loss. While age (p = 0,416), length of stay (p = 1,000), the presence of a barrier (p = 0,465) did not have a significant correlation with hearing loss. Conclusion: Housewives who were exposed to noise have the potential risk of hearing loss. Therefore, efforts must be made to adjust the distance of the settlement and the installation of sound dampers to reduce the risk of hearing loss.

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Stress hormonal changes in the brain and plasma after acute noise exposure in mice

Cited by 12 publications

References 18 publications

Pengaruh Kebisingan Terhadap Tekanan Darah dan Nadi pada Pekerja Pabrik Kayu PT. Muroco Jember

Pengaruh Kebisingan Terhadap Tekanan Darah dan Nadi pada Pekerja Pabrik Kayu PT. Muroco Jember

Evidence of Tinnitus Development Due to Stress: An Experimental Study in Rats

The Potential Risk of Hearing Loss on Noise-Exposed Housewives : An Observational Study at Sukosari Madiun Railway Residentia

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