“…Among these several types of RNA granules, SGs are specialized cytoplasmic membraneless RNA granules, which are composed of SG core components including untranslated polyadenylated RNAs, RNA-binding proteins including poly-A binding protein (PABP), T-cell intracellular antigen1 (TIA-1), pre-initiation complex (PIC), and 40S ribosomal subunits, involved in pausing mRNA translation upon various cellular stresses ( Decker and Parker, 2012 ). Although SG core components are common between subtypes of SGs, SG components are very heterogenous depending on cellular stress, or their subcellular localization ( Aulas et al, 2017 ; Advani and Ivanov, 2020 ; Boncella et al, 2020 ). Several RNA-binding proteins, including SG nucleators or auxiliary factors, could contribute to the dynamic assembly or disassembly of SGs.…”