Stress exposure and sensitivity in the clinical high-risk syndrome: Initial findings from the North American Prodrome Longitudinal Study (NAPLS)

Trotman, Hanan D.; Holtzman, Carrie W.; Walker, Elaine F.; Addington, Jean; Bearden, Carrie E.; Cadenhead, Kristin S.; Cannon, Tyrone D.; Cornblatt, Barbara A.; Heinssen, Robert; Mathalon, Daniel H.; Tsuang, Ming T.; Perkins, Diana O.; Seidman, Larry J.; Woods, Scott W.; McGlashan, Thomas H.

doi:10.1016/j.schres.2014.09.017

Cited by 70 publications

(60 citation statements)

References 24 publications

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“…As expected, and consistent with previous studies (e.g., 9, 49), the association of both types of stressors with PEs was also greater in the early‐psychosis group compared to the non‐clinical group (even if the latter was oversampled for elevated scores on schizotypy to include a wide range of variability in terms of psychosis liability). Results thus seem to indicate that, although comparable mechanisms, such as stress sensitivity, operate across different levels of psychotic liability, and expression, there is also a differential impact of stressors in both groups reflecting individual differences in risk and resilience factors, some of which may pave the way toward psychotic outcomes.…”

Section: Discussionsupporting

confidence: 90%

The role of stress‐regulation genes in moderating the association of stress and daily‐life psychotic experiences

Cristóbal-Narváez

Sheinbaum

Myin-Germeys

et al. 2017

Acta Psychiatr Scand

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ObjectiveThe interaction of single nucleotide polymorphisms with both distal and proximal environmental factors across the extended psychosis phenotype is understudied. This study examined (i) the interaction of relevant SNPs with both early‐life adversity and proximal (momentary) stress on psychotic experiences (PEs) in an extended psychosis sample; and (ii) differences between early‐psychosis and non‐clinical groups for these interactions.MethodsTwo hundred and forty‐two non‐clinical and 96 early‐psychosis participants were prompted randomly eight times daily for 1 week to complete assessments of current experiences, including PEs and stress. Participants also reported on childhood trauma and were genotyped for 10 SNPs on COMT, RGS4, BDNF, FKBP5, and OXTR genes.ResultsUnlike genetic variants, distal and proximal stressors were associated with PEs in both samples and were more strongly associated with PEs in the early‐psychosis than in the non‐clinical group. The RGS4 TA and FKBP5 CATT haplotypes interacted with distal stress, whereas the A allele of OXTR (rs2254298) interacted with proximal stress, increasing momentary levels of PEs in the early‐psychosis group. No interactions emerged with COMT or BDNF variants.ConclusionIndividual differences in relevant stress‐regulation systems interact with both distal and proximal psychosocial stressors in shaping the daily‐life manifestation of PEs across the psychosis continuum.

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Section: Discussionsupporting

confidence: 90%

The role of stress‐regulation genes in moderating the association of stress and daily‐life psychotic experiences

Cristóbal-Narváez

Sheinbaum

Myin-Germeys

et al. 2017

Acta Psychiatr Scand

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“…This has been supported by numerous subsequent studies (Holtzman et al, 2013). Similarly, CHR patients who later converted to psychosis reported a greater number of life events, and perceived these events as more stressful, compared to healthy controls and CHR subjects whose symptoms remitted (Trotman et al, 2014). Perceived stress levels in CHR patients are generally high (Moskow et al, 2016), and in some studies they even exceed ratings in FEP patients (Pruessner et al, 2011, Palmier-Claus et al, 2012.…”

Section: Stress Exposure Perceived Stress and Early Life Adversitymentioning

confidence: 72%

“…Both animal (Liu et al, 1997, Anisman et al, 1998 and human (Devylder et al, 2013, Trotman et al, 2014 studies have shown that previous exposure to stressful events can lead to stress-sensitization and dysregulation of the HPA response when confronted with subsequent stressors, both of which are believed to be critical contributors to the development of psychosis. Trauma victims not only responded with more subjective distress to stressful experiences later in life (Veling et al, 2016), the experience of early life adversity also predicted attenuated cortisol responses to a public speaking task in a dose-dependent fashion (Lovallo et al, 2012).…”

Section: Stress Exposure Perceived Stress and Early Life Adversitymentioning

confidence: 99%

The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

Pruessner

Cullen

Aas

et al. 2017

Neuroscience & Biobehavioral Reviews

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178

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. (2017). The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities. Neuroscience and biobehavioral reviews, 73, 191-218. https://doi.org/10. 1016/j.neubiorev.2016.12.013 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim.

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“…For example, CHR individuals report more stress than healthy controls (HCs) (Cullen et al, 2014; Pruessner et al, 2011). In a report based on the first half of the North American Prodrome Study (NAPLS-2) cohort, aged 13 to 30 years, CHR subjects reported more daily stress than HCs, and the CHR subjects who subsequently converted to psychosis reported greater stress than remitted CHR subjects, with those who remained prodromal falling in between (Trotman et al, 2014). Also, of interest to note, there was a trend for a more pronounced relation between stress and age for the CHR group.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, there are now enough subjects in the 13 to 19 year age-range to examine TS. Based on the evidence that both stress indices and prodromal/psychotic symptoms increase through the adolescent years, and that age-related increases in stress may be greater for CHR subjects (Trotman et al, 2014), it is hypothesized that CHR youth will show a more pronounced relation of age and Tanner pubertal stage with self-reported daily stress and basal cortisol.…”

Section: Introductionmentioning

confidence: 99%

The relations of age and pubertal development with cortisol and daily stress in youth at clinical risk for psychosis

Moskow

Addington

Bearden

et al. 2016

Schizophrenia Research

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BACKGROUND Prodromal syndromes often begin in adolescence – a period of neurodevelopmental changes and heightened stress sensitivity. Research has shown elevated stress and cortisol in individuals at clinical high risk (CHR) for psychosis. This cross-sectional study examined relations of age and pubertal status with cortisol and self-reported stress in healthy controls (HCs) and CHR adolescents. It was hypothesized that the relations of age and pubertal stage with cortisol and stress would be more pronounced in CHR youth. METHODS Participants were 93 HCs and 348 CHR adolescents from the North American Prodrome Longitudinal Study (NAPLS). At baseline, measures of stress (Daily Stress Inventory – DSI), Tanner stage (TS), and salivary cortisol were obtained. RESULTS ANCOVA revealed increased DSI scores with age for both groups, and higher DSI scores in CHR adolescents than HCs, with a more pronounced difference for females. Contrary to prediction, with age controlled, HCs showed greater TS-related DSI increases. Analysis of cortisol showed no significant interactions, but a main effect of age and a trend toward higher cortisol in the CHR group. Correlations of cortisol with TS were higher in HC than CHR group. CONCLUSIONS Stress measures increased with age in HC and CHR adolescents, and DSI scores also increased with TS in HCs. The results do not support a more pronounced age or TS increase in stress measures in CHR adolescents, but instead suggest that stress indices tend to be elevated earlier in adolescence in the CHR group. Potential determinants of findings and future directions are discussed.

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Stress exposure and sensitivity in the clinical high-risk syndrome: Initial findings from the North American Prodrome Longitudinal Study (NAPLS)

Cited by 70 publications

References 24 publications

The role of stress‐regulation genes in moderating the association of stress and daily‐life psychotic experiences

The role of stress‐regulation genes in moderating the association of stress and daily‐life psychotic experiences

The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

The relations of age and pubertal development with cortisol and daily stress in youth at clinical risk for psychosis

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