Stress effects on BDNF expression: Effects of age, sex, and form of stress

Bath, Kevin G.; Schilit, A.; Lee, F.S.

doi:10.1016/j.neuroscience.2013.01.074

Cited by 170 publications

(134 citation statements)

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“…One of the techniques is affecting the motherinfant interaction during the first weeks of postnatal life, which corresponds to the third trimester of fetal development and early postnatal development in humans. 17 Maternal separation, which inflicts a profound stress for both the pups and their mothers, is the most widespread method, 18,19 and can be used to model serious childhood incidences in human subjects. The behavioral and biological consequences in adulthood resemble those of human depression.…”

Section: Introductionmentioning

confidence: 99%

Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Santangeli

Lehtikuja

Palomäki

et al. 2016

Sleep

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Study Objective: Adverse early-life events induce behavioral psychopathologies and sleep changes in adulthood. In order to understand the molecular level mechanisms by which the maltreatment modifies sleep, valid animal models are needed. Changing pups between mothers at early age (cross-fostering) may satisfyingly model adverse events in human childhood. Methods: Cross-fostering (CF) was used to model mild early-life stress in male and female Wistar rats. Behavior and BDNF gene expression in the basal forebrain (BF), cortex, and hypothalamus were assessed during adolescence and adulthood. Spontaneous sleep, sleep homeostasis, and BF extracellular adenosine levels were assessed in adulthood. Results: CF rats demonstrated increased number of REM sleep onsets in light and dark periods of the day. Total REM and NREM sleep duration was also increased during the light period. While sleep homeostasis was not severely affected, basal level of adenosine in the BF of both male and female CF rats was lower than in controls. CF did not lead to considerable changes in behavior. Conclusions: Even when the consequences of adverse early-life events are not observed in tests for anxiety and depression, they leave a molecular mark in the brain, which can act as a vulnerability factor for psychopathologies in later life. Sleep is a sensitive indicator for even mild early-life stress.

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Section: Introductionmentioning

confidence: 99%

Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Santangeli

Lehtikuja

Palomäki

et al. 2016

Sleep

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“…Postnatal development, lactation, and adolescence are periods of high sensitivity to stress when epigenetic changes may program the individual to having low stress resilience, changing the expression of key molecules such as BDNF and GR in a region-specific manner; in hippocampus their inhibited expression alters the inhibitory feedback on the activity of the HPA leading to hyperactive stress responses and reduced learning (Meaney & Szyf 2005, Pervanidou & Chrousos 2012, Bath et al 2013. The nutrition or stress experience of mothers during gestation as well as litter size has longlasting effects on metabolism and stress response (Breton 2013).…”

Section: Neuroendocrinology Revisitedmentioning

confidence: 99%

“…Neonatal stress produced by maternal separation causes epigenetic changes in hippocampal Gr and Bdnf promoters, their reduced expression contributes to the altered HPA-response to stressors in adulthood (Meaney & Szyf 2005), Bdnf expression is altered in a strain-, sex-, and region-specific manner (Bath et al 2013). Adequate programing of activity and response of the HPT axis is altered under various conditions.…”

Section: Neuroendocrinology Revisitedmentioning

confidence: 99%

Regulation of TRH neurons and energy homeostasis-related signals under stress

Joseph‐Bravo

Jaimes-Hoy

Charlí

2015

Journal of Endocrinology

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Energy homeostasis relies on a concerted response of the nervous and endocrine systems to signals evoked by intake, storage, and expenditure of fuels. Glucocorticoids (GCs) and thyroid hormones are involved in meeting immediate energy demands, thus placing the hypothalamo-pituitary-thyroid (HPT) and hypothalamo-pituitary-adrenal axes at a central interface. This review describes the mode of regulation of hypophysiotropic TRHergic neurons and the evidence supporting the concept that they act as metabolic integrators. Emphasis has been be placed on i) the effects of GCs on the modulation of transcription of Trh in vivo and in vitro, ii) the physiological and molecular mechanisms by which acute or chronic situations of stress and energy demands affect the activity of TRHergic neurons and the HPT axis, and iii) the less explored role of non-hypophysiotropic hypothalamic TRH neurons. The partial evidence gathered so far is indicative of a contrasting involvement of distinct TRH cell types, manifested through variability in cellular phenotype and physiology, including rapid responses to energy demands for thermogenesis or physical activity and nutritional status that may be modified according to stress history.

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“…BDNF is a secreted protein involved in the survival, growth, and development of neurons and proper synapse formation (Bibel and Barde, 2000;Bath et al, 2013). BDNF and NGF are neurotrophins that can prevent neuronal apoptosis (Bibel and Barde, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats

Shuai

Wang

Xiong

et al. 2014

Bangladesh J Pharmacol

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Research ArticleEffects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats BJP IntroductionAbout 200 million patients worldwide are exposed to anesthesia and undergo surgery each year (Weiser et al., 2008;Moonesinghe et al., 2011). Volatile anesthetics such as isoflurane and sevoflurane are used in millions of young children each year during surgical procedures and imaging studies (Istaphanous and Loepke, 2009). Exposure to anesthetic cocktails (Yon et al., 2005;Lu et al., 2006;Sanders et al., 2009) or volatile agents such as isoflurane even as a single anesthetic (Yon et al., 2005;Ma et al., 2007) has been reported to be associated with widespread apoptotic neurodegeneration in the developing brains and contributes to the post-operative cognitive dysfunction (POCD) (Jevtovic-Todorovic et al., 2003;Satomoto et al., 2009;Brambrink et al., 2010;Kong et al., 2011;Paule et al., 2011; Li et al., 2013a,b).In rodent models, the effects of anesthesia have been evaluated following exposure during a time of peak brain development and synaptogenesis, typically at postnatal day 7 (P7) (Jevtovic-Todorovic et al., 2003;Stratmann et al., 2009b;Shih et al., 2012). Apoptosis has been observed to occur acutely in the period immediately following anesthesia (Jevtovic-Todorovic et al., 2003;Istaphanous et al., 2011;Shih et al., 2012), and the thalamus and hippocampus are known areas susceptible to extensive neurodegeneration (JevtovicTodorovic et al., 2003;Satomoto et al., 2009;Shih et al., 2012). AbstractDevelopmental abnormalities, neuronal apoptosis and associated cognitive impairment following isoflurane exposure in neonatal rodents have been reported. The study was undertaken to investigate the effect of vitamin C supplementation against isoflurane-induced neurotoxicity. Seven day old rats were exposed to 1.1% isoflurane, or air for 6 hours. Treatment groups were administered with vitamin C (30 mg/kg, orally) from postnatal day 1 (P1) to P10 and were exposed to isoflurane on P7. Isoflurane exposure induced apoptosis was determined by Fluoro-Jade C and terminal deoxynucleotidyltransferase-mediated 2'-deoxyuridine 5'-triphosphate nick-end labeling assay. Vitamin C considerably improved memory and learning impairments, modulated neuroapoptosis and improved expressions of brain-derived neurotrophic factor, nerve growth factor, Bcl-xL and decreased activated caspase-3 expressions. Thus, vitamin C effectively offered protection against isoflurane-induced neuronal apoptosis, learning and memory disturbances. Article Info

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Stress effects on BDNF expression: Effects of age, sex, and form of stress

Cited by 170 publications

References 88 publications

Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Regulation of TRH neurons and energy homeostasis-related signals under stress

Effects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats

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