Stress, cortisol, and obesity: a role for cortisol responsiveness in identifying individuals prone to obesity

Hewagalamulage, Sakda D.; Lee, Kevin; Clarke, Iain J.; Henry, Belinda A.

doi:10.1016/j.domaniend.2016.03.004

Cited by 111 publications

(94 citation statements)

References 107 publications

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“…La menor cantidad de horas de sueño (5 horas) favorece a que se ingiera una mayor cantidad de energía y con ello la ganancia de peso. Por otro lado, la disminución de sueño aumenta los niveles de cortisol por el eje-hipotálamo-pituitaria-adrenal, lo cual favorece la distribución de grasa a nivel abdominal (Hewagalamulage et al 2016;Joseph et al 2016). …”

Section: Discussionunclassified

Relación entre la calidad de sueño con el grado de obesidad y circunferencia de cintura en comerciantes del Gran Mercado Mayorista de Lima, 2016

Vera

Briceño²

2017

riu

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Relación entre la calidad de sueño con el grado de obesidad y circunferencia de cintura en comerciantes del Gran Mercado Mayorista de Lima, 2016 Relationship between quality of sleep with the degree of obesity and waist circumference in merchants of the Great Wholesale Market of Lima, 2016Plaza Vera, Karem Johanna; Ambulay Briceño, Johnny Percy EP de Nutrición Humana, Facultad de Ciencias de la Salud, Universidad Peruana Unión Recibido el 8 de setiembre del 2015 -Aceptado el 14 de noviembre del 2015 ResumenObjetivo: Determinar la relación entre la calidad de sueño con el grado de obesidad y circunferencia de cintura. Materiales y Métodos: Se realizó un análisis transversal en 198 comerciantes de 30 a 59 años: 116 mujeres y 86 varones. Se evaluó la calidad de sueño a través del índice de calidad de sueño Pittsburg; asimismo, se midió el peso, talla y circunferencia de la cintura en la ficha antropométrica para calcular el grado de obesidad y circunferencia de cintura y clasificarlo según la OMS. Resultados: En ambos sexos hay mayor prevalencia de obesidad tipo II y de riesgo aumentado de enfermedades cardiovasculares, así como una mala calidad de sueño. Finalmente, se observó una relación significativa entre la calidad de sueño con el grado de obesidad y circunferencia de cintura en las mujeres y no en los varones. Conclusión: Se sugiere que la mala calidad de sueño está relacionado con el aumento de riesgo a desarrollar obesidad y riesgo cardiometabólico.Palabras clave: Calidad de sueño, obesidad, circunferencia de cintura. AbstractObjective: To determine the relationship between sleep quality and the degree of obesity and waist circumference. Materials and Methods: A cross-sectional analysis of 198 marketers aged 30 to 59 years was carried out, 116 women and 86 boys were evaluated for sleep quality through the Pittsburgh Sleep Quality Index, as well as weight, height and waist circumference In the anthropometric chart to calculate the degree of obesity and waist circumference and to classify it according to the WHO. Results: In both sexes there is a higher prevalence of type II obesity and an increased risk of cardiovascular diseases, as well as poor sleep quality. Finally, a significant relationship was observed between sleep quality and the degree of obesity and waist circumference in the Women and not in males. Conclusion: It is suggested that poor sleep quality is related to increased risk of developing obesity and cardio metabolic risk.Keywords: Sleep quality. Obesity. Waist circumference. IntroducciónDiversos estudios han demostrado que la calidad de sueño está relacionada con la obesidad. El sueño es una necesidad humana básica. El número de horas necesarias que un individuo promedio debe dormir diariamente para mantener un funcionamiento adecuado durante la vigilia se ha definido en 7 horas. La calidad de sueño no solo está definido como el dormir bien durante la noche sino también tener un desempeño adecuado durante la vigilia (Granados et al. 2013).La mala calidad de sueño y los trastornos asociado...

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Section: Discussionunclassified

Relación entre la calidad de sueño con el grado de obesidad y circunferencia de cintura en comerciantes del Gran Mercado Mayorista de Lima, 2016

Vera

Briceño²

2017

riu

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“…Various stressful life events are reflected as “stressor” [11] which adversely affect the physiological processes. High intensity and/or long term exposure to circulating GCs are capable of showing the profound effects on intake of “comfort food” (fat and sugar, enriched food) that in turn cause a relative increase in body weight and subsequent obesity [14]. Once exposure to stressor, specific pathways within the brain lead to activation of the hypothalamo-pituitary-adrenal (HPA) axis as well as central sympathetic outflow.…”

Section: The Impact Of Psychosocial Stress and Glucocorticoids On Bodmentioning

confidence: 99%

“…Moreover, POMC influences synaptic inputs for appetite stimulators NPY and AgRP. It stimulates the nexus in the hypothalamus that controls food intake which may lead to weight gain [14]. The normal physiology of food intake and energy expenditure is managed by functioning of POMC cells as well as the number of excitatory inputs to neuroendocrine systems [27, 28].…”

Section: The Impact Of Psychosocial Stress and Glucocorticoids On Bodmentioning

confidence: 99%

“…Noticeable rise in ROS production, because of excessive glucocorticoids secretion during prolonged stress, activates liver degenerative processes through extrinsic and intrinsic pathways of cell death. Alongside these detrimental effects of the glucocorticoids, “The Kelch ECH associated protein 1 (Keap1) -Nrf2 pathway” which promotes liver regeneration [14, 52] is also activated by the glucocorticoids. Thus, both apoptosis and regenerative pathways are fine-tuned by the glucocorticoids signaling and the outcome would be determined by alteration in any of the two mechanisms.…”

Section: The Impact Of Psychosocial Stress and Glucocorticoids On Bodmentioning

confidence: 99%

“…Deviant increase in glucocorticoids following stress-arousal influences both food consumption and energy expenditure [12, 13]. Studies in human subjects strongly suggest a correlation between prolonged elevation of circulating glucocorticoids and weight gain [14]. It has been acknowledged for years that, subsequent to chemical or surgical insult, the liver undergoes repairs processes to regenerate tissue possessing anatomical or functional characteristics of hepatocytes [15].…”

Section: Introductionmentioning

confidence: 99%

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Psychosocial-Stress, Liver Regeneration and Weight Gain: a Conspicuous Pathophysiological Triad

Ishtiaq

Khan

Arshad

2018

Cell Physiol Biochem

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Psychosocial stress alters several physiological parameters resulting in multiple disorders, particularly compromising the immune system thereby provoking various diseases including liver disorders. However, the plausible underlying mechanisms remain elusive. Recent literature provides mechanistic evidences of detrimental effects of psychosocial stress on physiology of different body organs including liver. The data of stress-induced pathophysiological changes in liver functions and obesity were systematically collected from PubMed, ScienceDirect and the Web of Science Databases published in English. Stress and glucocorticoids (GCs) control food intake and energy expenditure through appetite stimulators neuropeptide Y (NYP) and agouti-related protein (AgRP) in hypothalamus. Principle effectors of the activated hypothalamic-pituitary-adrenal (HPA) axis in response to psychosocial stress are proopiomelanocortin (POMC)-derived adrenocorticotropic hormone (ACTH) and GCs. Stress-induced GCs hyper-secretion triggers glucocorticoid receptor (GR)-dependent transcriptional factor, nuclear factor kappa B (NFκB), which interferes TNFα-IL6 and keap1-Nrf2 pathways in liver regeneration and obesity through fine-tuning of TNFα, IL6 and Nrf2 signaling. In this review, it is contrived upon existing evidence to put forward a model whereby exposure to life-stress has a prominent impact over weight gain and can alter the regenerative mode of a damaged liver through Keap1-Nrf2 and TNFa-IL6 pathways.

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Association between psychological resilience and body mass index in a community‐based population: A cross‐sectional study

Zheng,

Zhuang,

Zhu

et al. 2024

Obesity Science & Practice

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Background and ObjectiveWhile earlier studies have focused on the relationship between stress and obesity, there was a gap in understanding the potential impact of positive psychological factors, such as resilience, on obesity. By investigating the role of psychological resilience with obesity, this study aimed to address this gap and tackle obesity through a positive psychological framework.MethodsParticipants consisted of 2445 community residents from Shenzhen, China, with a mean age of 41.09 ± 13.72 years, comprising 846 males and 1599 females. Psychological resilience was measured using the Brief Resilience Scale; gender, age, marital status, education level, smoking status, alcohol consumption, frequency of physical exercise, and perceived stress were considered potential confounding factors. The relationship between psychological resilience and body mass index (BMI) was examined through multiple linear regression and logistic regression analyses.ResultsThe participants had an average psychological resilience score of 3.46 (standard deviation [SD] = 0.62) and an average BMI of 22.59 (SD = 3.35), with 104 individuals (4.3%) identified with obesity. In the fully adjusted multiple linear regression model, a higher psychological resilience score was associated with a higher BMI (β = 0.507, 95% CI:0.283, 0.731). In the logistic regression model, higher psychological resilience scores were linked to increased obesity risk, with a more significant association observed among males (odds ratio [OR] = 2.169, 95% CI:1.155, 4.073), while psychological resilience acted as a protective factor against underweight among females (OR = 0.528, 95% CI:0.376, 0.816).ConclusionThe study demonstrated a significant link between higher psychological resilience and elevated BMI, emphasizing the complex relationship between psychological fortitude and weight management. Interventions targeting socioeconomic status, education, lifestyle habits, and physiological well‐being might offer a promising strategy for enhancing psychological resilience and promoting healthier weight. Emphasizing self‐efficacy and coping skills at the individual level could contribute to balanced weight and comprehensive health outcomes, addressing the global challenge of obesity.

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Stress, cortisol, and obesity: a role for cortisol responsiveness in identifying individuals prone to obesity

Cited by 111 publications

References 107 publications

Relación entre la calidad de sueño con el grado de obesidad y circunferencia de cintura en comerciantes del Gran Mercado Mayorista de Lima, 2016

Relación entre la calidad de sueño con el grado de obesidad y circunferencia de cintura en comerciantes del Gran Mercado Mayorista de Lima, 2016

Psychosocial-Stress, Liver Regeneration and Weight Gain: a Conspicuous Pathophysiological Triad

Association between psychological resilience and body mass index in a community‐based population: A cross‐sectional study

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