Stress biomarkers as predictors of transition to psychosis in at-risk mental states: Roles for cortisol, prolactin and albumin

Labad, Javier; Stojanovic-Pérez, Alexander; Montalvo, Itziar; Solé, Montse; Cabezas, Ángel; Ortega, Laura; Moreno, I. Huguet; Vilella, Elisabet; Martorell, Lourdes; Reynolds, Rebecca M.; Gutiérrez-Zotes, Alfonso

doi:10.1016/j.jpsychires.2014.10.011

Cited by 96 publications

(61 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, a study examining fasting morning levels of both salivary and plasma cortisol obtained at a single time-point in a laboratory setting reported that CHR youth did not differ significantly from healthy controls on either measure (Labad et al, 2015). Similarly, two recent studies, which implemented a home saliva sampling protocol, failed to observe increased diurnal cortisol among CHR youth (Day et al, 2014) or children with either a family history of illness or multiple antecedents of schizophrenia (Cullen et al, 2014b).…”

Section: Baseline Cortisolmentioning

confidence: 84%

“…Similarly, another recent study found no difference in cortisol levels over two hours after awakening between CHR individuals and controls, but observed a significantly blunted cortisol response in male compared to female patients (Carol et al, 2016). Yet another recent study observed an increased CAR in at-risk youth who transitioned to psychosis within one year relative to both CHR youth who did not transition and healthy controls (Labad et al, 2015). Considering the conflicting evidence, a recent systematic review and meta-analysis on the CAR in patients at different stages of the psychosis continuum comes to the conclusion that the CAR is attenuated in patients with established psychosis, but not in individuals at CHR (Berger et al, 2016).…”

Section: Cortisol Awakening Responsementioning

confidence: 99%

See 1 more Smart Citation

The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

Pruessner

Cullen

Aas

et al. 2017

Neuroscience & Biobehavioral Reviews

241

178

View full text Add to dashboard Cite

. (2017). The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities. Neuroscience and biobehavioral reviews, 73, 191-218. https://doi.org/10. 1016/j.neubiorev.2016.12.013 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim.

show abstract

Section: Baseline Cortisolmentioning

confidence: 84%

Section: Cortisol Awakening Responsementioning

confidence: 99%

The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

Pruessner

Cullen

Aas

et al. 2017

Neuroscience & Biobehavioral Reviews

241

178

View full text Add to dashboard Cite

show abstract

“…Aston et al (2010) and Garcia-Rizo et al (2012) reported increased prolactin levels in those patients. Labad et al (2015) suggest that increased prolactin levels are associated with the risk of developing psychosis in individuals at risk of psychosis. Segal et al (2007) found no difference in prolactin levels between unmedicated patients with schizophrenia and controls, but they reported higher prolactin levels in a subgroup of disorganised schizophrenic patients.…”

Section: Introductionmentioning

confidence: 99%

Prolactin levels in drug-naïve patients with schizophrenia and other psychotic disorders

Petrikis

Tigas

Tzallas

et al. 2016

International Journal of Psychiatry in Clinical Practice

View full text Add to dashboard Cite

show abstract

“…Comorbid Axis I disorders are typical of UHR individuals (Fusar-Poli et al, 2014); therefore, it is possible that comorbid symptoms could add to the diathesis of psychosis. In fact, stress hormone elevations in UHR individuals has also been linked to anxiety (Corcoran et al, 2012), suspiciousness (Corcoran et al, 2012), stressful life events (Labad et al, 2014), and stress intolerance (Pruessner et al, 2013a). Future studies that specifically examine the interplay between comorbid disorders and HPA axis dysfunction in UHR individuals are needed to better understand the relationship between symptomatology, the progression of psychosis risk symptoms, and HPA axis functioning.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in morning cortisol in youth at ultra-high-risk for psychosis

Carol

Spencer

Mittal

2016

Psychoneuroendocrinology

View full text Add to dashboard Cite

Summary Research suggests abnormalities in hypothalamic-pituitary-adrenal (HPA) axis function play an important role in the pathophysiology of psychosis. However, there is limited research on the biological stress system in young people at ultra high risk (UHR) for psychosis. Morning cortisol levels are particularly relevant to study in this context, as these markers reflect HPA regulation. This is the first examination of sex differences in morning cortisol levels in UHR individuals. Twenty-eight UHR and 22 matched healthy control participants were assessed in respect to symptoms and had home-based collection of salivary cortisol over three time points in the morning. It was predicted that the UHR participants would exhibit lower morning cortisol levels and lower cortisol would be associated with greater symptomatology (i.e. higher positive, negative, and depressive symptoms). Additionally, sex differences in morning cortisol levels were explored based on recent evidence suggesting that sex differences may play an important role in the exacerbation of psychosis. While there were no group differences in morning salivary cortisol secretion, there was a sex by time interaction among UHR individuals, such that only UHR males exhibited flat cortisol levels across two hours after awakening, whereas UHR females had a pattern of cortisol secretion similar to healthy controls, even among medication-free individuals (F = 6.34, p = 0.004). Cortisol AUC (area under the curve) across the three time points had a trend association (medium effect size; r = 0.34, p = 0.08) with depressive, but not positive or negative, symptom severity. These results stress the importance of considering sex differences in the psychosis-risk period, as they improve understanding of pathogenic processes.

show abstract

Stress biomarkers as predictors of transition to psychosis in at-risk mental states: Roles for cortisol, prolactin and albumin

Cited by 96 publications

References 50 publications

The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

Prolactin levels in drug-naïve patients with schizophrenia and other psychotic disorders

Sex differences in morning cortisol in youth at ultra-high-risk for psychosis

Contact Info

Product

Resources

About