Stress at work alters serum brain-derived neurotrophic factor (BDNF) levels and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in healthy volunteers: BDNF and MHPG as possible biological markers of mental stress?

Mitoma, Masae; Yoshimura, Reiji; Sugita, Atsuko; Umene, Wakako; Hori, Hikaru; Nakano, Hirofumi; Ueda, Nobuhisa; Nakamura, Jun

doi:10.1016/j.pnpbp.2007.11.011

Cited by 87 publications

(66 citation statements)

References 58 publications

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“…This suggests that the measure may be used to screen for novel antidepressant agents or possibly even predict an individual's response to an antidepressant treatment at an early time point after treatment initiation if a relationship can be established between the change in BDNF levels and clinical response. However, it is important to recognize that plasma and serum BDNF levels have also been shown to correlate with other events and activities such as food intake (37), stress (38), and exercise (39), that are likely to complicate the interpretation of the findings and possibly limit the true utility of the measure. On the other hand, it is worthy of note that some of these conditions are known to either exacerbate or precipitate depression (e.g., stress), or produce an antidepressant response (5).…”

Section: What Is the Utility Of The Measure As A Biomarker?mentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen

Duman

Sanacora

2008

Biological Psychiatry

1,083

715

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Section: What Is the Utility Of The Measure As A Biomarker?mentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen

Duman

Sanacora

2008

Biological Psychiatry

1,083

715

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“…Mean (± standard deviation) of log transfer low-frequency power of heart rate variability (LF power), HFnu, LFnu, LF/HF, age, smoking status and alcohol consumption for job stress group stratified by duration of employment norepinephrine, during the workday were higher than those found in earlier studies of professional drivers, and the recovery period after the completion of daily work was relatively insufficient 11) . A recent biomarker study of 106 Japanese hospital workers with greater psychological job stress reported lower brain-derived neurotrophic factor levels and higher plasma 3-methoxy-4-hydroxyphenylglycol levels than in workers suffering from less job stress 23) . However, presently there was no significant correlation between job-related stress and the levels of urinary catecholamines.…”

Section: Discussionmentioning

confidence: 93%

Heart Rate Variability and Urinary Catecholamines from Job Stress in Korean Male Manufacturing Workers According to Work Seniority

Lee

Yoon

et al. 2010

Ind Health

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“…When administered to patients with MDD, some antidepressants increase plasma MHPG, whereas other antidepressants decrease or do not change the plasma MHPG level. We demonstrated that paroxetine, an SSRI, decreased plasma MHPG, and that the SNRI milnacipran increased plasma MHPG; we also reviewed the effects of several antidepressants on plasma MHPG levels [3][4][5][6][7][8][9]. We also found that plasma MHPG is useful for predicting relapse to a major depressive episode in MDD patients [8].…”

mentioning

confidence: 90%

Can Plasma Level of 3-methoxy-4-hydroxyphenylglycol Predict the Response for Selective Serotonin Reuptake Inhibitor and Serotonin Noradrenaline Reuptake Inhibitor in Major Depressive Disorder?

Yoshimura¹,

Katsuki²,

Atake³

et al. 2017

J Depress Anxiety

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IntroductionDepression is a serious mental illness requiring treatment. Major depressive disorder (MDD) is a complex disorder confounded by many bio psychosocial factors. Treatment with selective serotonin reuptake inhibitors (SSRIs) or serotonin noradrenaline reuptake inhibitors (SNRIs) is useful for MDD. The treatment of MDD requires collaborative efforts and holistic approaches by healthcare providers, public health interventions, and a reform in policies as well as the allocation of resources for the effective management of individuals with MDD, especially those with geriatric depression [1,2].A major metabolite of noradrenaline, 3-methoxy-4-hydroxyphenylglycol (MHPG), passes the blood-brain barrier. It is thought that 30% to 60% of plasma MHPG originates in the brain. When administered to patients with MDD, some antidepressants increase plasma MHPG, whereas other antidepressants decrease or do not change the plasma MHPG level. We demonstrated that paroxetine, an SSRI, decreased plasma MHPG, and that the SNRI milnacipran increased plasma MHPG; we also reviewed the effects of several antidepressants on plasma MHPG levels [3][4][5][6][7][8][9]. We also found that plasma MHPG is useful for predicting relapse to a major depressive episode in MDD patients [8]. Another of our studies showed that switching from paroxetine to milnacipran did not alter plasma MHPG levels [9]. We conducted the present study to investigate whether MDD patients' responses to an SSRI and an SNRI can be predicted based on plasma MHPG. Patients and MethodsPatients (n=240) with MDD diagnosed based on DSM-IV-TR were enrolled. All participants were undergoing monotherapy with the SSRI paroxetine (n=81), duloxetine, a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI) (n=49), the SNRI milnacipran (n=48), the SSRI fluvoxamine (n=63), or the SSRI escitalopram (n=27). Only benzodiazepines were permitted during the study period. The patients (102 males, 138 females) were 42 ± 19 years old (mean ± SD). The severity of each patient's depressive state was evaluated with the 17-item Hamilton Rating Scale for Depression (HAMD17). The end-point point of the present study was week 8.Patients whose HAMD17 scores had decreased by ≥50% at the study end-point were defined as responders; others were considered non-responders. Blood was drawn twice before and 8 weeks after the start of treatment. Plasma MHPG levels were measured using highperformance liquid chromatography (HPLC) with electrochemical detection according to the method reported by Minegishi and Ishizaki [10]. Briefly, the plasma was separated by centrifugation at 600 g at 4°C. Extraction was performed under a vacuum using Bond-Elut columns (Varian, Palo Alto, CA) pre packed with 100 mg of C18-bonded silica (40 μm) in a 1 mL capacity disposable syringe. The columns, which were inserted into a vacuum chamber connected to an aspirator, were prepared by washing with 1 mL methanol followed by 1 mL of water.After the addition of 50 μL of a solution of vanillyl alcohol (in...

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Stress at work alters serum brain-derived neurotrophic factor (BDNF) levels and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in healthy volunteers: BDNF and MHPG as possible biological markers of mental stress?

Cited by 87 publications

References 58 publications

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Heart Rate Variability and Urinary Catecholamines from Job Stress in Korean Male Manufacturing Workers According to Work Seniority

Can Plasma Level of 3-methoxy-4-hydroxyphenylglycol Predict the Response for Selective Serotonin Reuptake Inhibitor and Serotonin Noradrenaline Reuptake Inhibitor in Major Depressive Disorder?

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