Stress and the acute gastric mucosal lesion

Moody, Frank G.; Cheung, Laurence Y.; Simons, Margaret A.; Zalewsky, Charlotte A.

doi:10.1007/bf01072062

Cited by 55 publications

(14 citation statements)

References 35 publications

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“…However, assuming that the mucosal flow amounts to 60--70% [2] of the total flow to the stomach, our values of a mean percentage of 0.64% for total mucosal blood flow fall in line with that reported by Sasaki and Wagner [8] and Blahitka and Rakusan [2]. In all animal models of shock induced stress ulcerations studied so far, the mucosal lesion spare the antrum [2,5,7,10] and it has been demonstrated, that this is paralleled by a more rapid deterioration of the energy state of cells in the corpus than in the antral area, as evidenced by the energy charge of the adenylate pool [5]. Since overall decrease of gastric mucosal blood flow is a constant feature of shock and gastric mucosal ischemia has been implicated as one of the major factors in the development of stress lesions [9], one could speculate whether or not these differences in energy metabolism are a consequence of different degrees of ischemia.…”

Section: Discussionsupporting

confidence: 88%

Regional gastric mucosal blood flow in hypovolemic shock

et al. 1979

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The effect of hypovolemia on the mucosal blood flow of the gastric corpus and antrum were tested with the microsphere method 30 and 60 min after induction of hemorrhagic shock in the rat. The results demonstrate a marked reduction after 30 and 60 min without any significant differences between the corpus and the antrum. This reduction is largely dependent on cardiac and circulatory function. It is concluded that the differences in energy metabolism, which have been implicated as explanation for the different susceptibility to develop stress lesions by Menguy and Masters, cannot be attributed tod different degrees of ischemia.

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Section: Discussionsupporting

confidence: 88%

Regional gastric mucosal blood flow in hypovolemic shock

et al. 1979

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“…On the other hand, the major factors implicated in the development of stress-induced gastric mucosal injury include an increase in gastric acid secretion and a decrease in mucosal protection due to the reductions in mucus secretion, mucosal blood flow and prostaglandin biosynthesis. 18) Therefore, in the next experiments, in order Artichoke leaf extract or test material was given orally 2 h prior to intragastric administration of absolute ethanol and the effects of test materials on gastric mucus content were evaluated 1 h after ethanol treatment. Each column denotes the meanϮS.E.M.…”

Section: Discussionmentioning

confidence: 99%

Effects of Artichoke Leaf Extract on Acute Gastric Mucosal Injury in Rats

Ishida

Kojima

Tsuboi

et al. 2010

Biological & Pharmaceutical Bulletin

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The present study was designed to clarify the effects of an ethanol extract of artichoke leaf on acute gastric mucosal injury in rats. Oral administration of artichoke leaf extract dose-dependently prevented absolute ethanol-induced (125-500 mg/kg) or restraint plus water immersion stress-induced gastric mucosal injury (1000-2000 mg/kg). The artichoke leaf extract contains 1% cynaropicrin and 0.8% chlorogenic acid as main components and 70% dextrin as a vehicle. Cynaropicrin at doses of 1/100 of artichoke leaf extract [ethanol-induced mucosal injury: 5 mg/kg, per os (p.o.); stress-induced mucosal injury: 20 mg/kg, p.o.] also prevented gastric mucosal injury in both animal models. However, dextrin and chlorogenic acid at doses contained in the leaf extract were ineffective in both models. When artichoke leaf extract was given orally to normal rats, it (500-2000 mg/kg, p.o.) dose-dependently increased gastric mucus content. In addition, it (125-500 mg/kg, p.o.) dosedependently prevented the decrease in gastric mucus content by absolute ethanol. When the effects of artichoke leaf extract on basal gastric acid secretion in rats were evaluated, it (500-2000 mg/kg, p.o.) dose-dependently increased the volume of gastric juice in normal rats. However, it was ineffective in decreasing basal gastric acid secretion in normal rats. These results indicate that artichoke leaf extract is effective against acute gastritis and its beneficial effect is due to that of cynaropicrin. The gastric mucus-increasing action of artichoke leaf extract may be, at least in part, related to the anti-gastritic action of the extract.

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“…Stress is known to cause acute erosion of the gastric mucosa in various mammals [12]. Restraint [13] and water immersion [14] techniques are often used to produce stressinduced gastrointestinal ulcers in different animal species.…”

Section: Introductionmentioning

confidence: 99%