A comparative study was performed on the mechanical and giant magnetoimpedance (GMI) properties in the longitudinal and transverse directions of Co 69 Fe 4 Ni 1 Mo 2 B 12 Si 12 amorphous ribbons. Both mechanical and GMI properties were found to be anisotropic. Kerr microscopy shows the presence of a stripe-type domain structure with the magnetic easy axis parallel to the longitudinal direction. The fracture strength, elastic modulus, and fracture toughness in the transverse direction was higher than those in the longitudinal direction. A larger GMI response was achieved in the transverse direction at a frequency range where both the domain wall motion and spin rotation dominantly contributed to the effective permeability and hence the magnetoimpedance. The current study paves the way for designing Co-rich amorphous ribbons as desirable components in electronics such as magnetic sensors.