Stress and Immune Responses II. Identification of Stress-Sensitive Cells in Murine Spleen Cells

Okimura, Tsutomu; Satomi-Sasaki, Yoko; Ohkuma, Shigenori

doi:10.1254/jjp.40.513

Cited by 16 publications

(6 citation statements)

References 39 publications

(12 reference statements)

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“…Pre-administration of metyrapone partially blocked the suppression of PFC response to TD antigen, but on the contrary, it inhibited the increase of number of PFC/106 spleen cells to TI antigen. We have previously demonstrated that both helper T cell and suppressor T cell activities were suppressed, but B cell activities were rather enhanced in splenocytes from restrained mice (24). In this study, the number of PFC/spleen to TNP-LPS was not increased by restraint stress.…”

Section: Discussioncontrasting

confidence: 37%

Stress and Immune Responses IV. Adrenal Involvement in the Alteration of Antibody Responses in Restraint-Stressed Mice

Okimura

Ogawa

Yamauchi

et al. 1986

Japanese Journal of Pharmacology

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Abstract-We investigated the correlation between restraint stress-induced alter ation of antibody responses and adrenal hormones. Adrenalectomy (Adx) blocked both the suppression of antibody response against T cell-dependent (TD) antigen and the enhancement of that against T cell-independent (TI) antigen in stressed mice. Adx also inhibited the atrophy of both thymus and spleen caused by restraint. Pre-treatment of metyrapone, an inhibitor of adrenocortical steroid biosynthesis, had an effect that was similar to, but far weaker than that of Adx on stressed mice. The pre-administration of phenoxybenzamine, an a-adrenergic blocking agent, to mice prevented both the inhibition of antibody response to TD antigen and the decrease in spleen cell number of restrained mice. A similar effect was observed in mice pre-treated with 6-hydroxydopamine, an adrenergic neuron degenerating agent.However, no effects of these two agents were observed on the enhancement of antibody response to TI antigen. The suppressive effect of the antibody response to TD antigen was augmented by the pre-administration of propranolol, a e3-adrenergic blocking agent. These results suggest that the suppression of the function of T cells in restrained mice are attributed to the released adrenocortical and adrenal medullary hormones and activated sympathetic nervous system and that the enhance ment of B cell function is due to the adrenocortical hormones.

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Section: Discussioncontrasting

confidence: 37%

Stress and Immune Responses IV. Adrenal Involvement in the Alteration of Antibody Responses in Restraint-Stressed Mice

Okimura

Ogawa

Yamauchi

et al. 1986

Japanese Journal of Pharmacology

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“…Okimura et at. [43] have reported that adherent cells from restrained mice have identical ability lo support the PFC (plaque-forming cell) response in Sephadex G-10 column-passed spleen cells (adherent cell depleted) as adherent cells from control mice. We have, on the other hand, observed a decreased ability in adherent cells from stressed mice to support mitogenesis of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand. Okimura et al [43] have reported that no differenee between antigen presenting eells from miee subjected to restraint stress and control mice could be observed. One aim ofthe present was to study in more detail whether stress directly affected Ihe accessory cells or the T lymphocytes, or both, when spleen cells were stimulated wilh mitogens.…”

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confidence: 96%

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The Effect of Various Contexts of Stress on the Mouse Spleen Lymphocytes and Macrophage Co‐stimulatory Activity

1991

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Mice stressed daily by brief cold water immersions for 1, 8 or 14 days showed changes in immune system function which were dependent on the number of mice per cage, frequency of stress exposures and total number of stress exposures. Changed percentages of spleen B and CD4, but not of CD8 cells were determined when the mice were stressed either once or twice daily. With CD4 cells, increased percentages were seen after stress once daily but a decreased percentage was seen after stress twice daily. Furthermore, the Concanavalin A-stimulated spleen cell mitogenesis was decreased after 1 day of stress in mice stressed once daily as opposed to after 8 and 14 days of stress in mice stressed twice daily. After 14 days of stress, the lipopolysaccharide stimulated mitogenesis was increased if the mice were stressed once daily but decreased if the mice were stressed twice daily. With two mice per cage, we observed a decreased spleen cell mitogenesis after 14 days of stress. With four mice per cage, the spleen cell mitogenesis was decreased after 8 and 14 days of stress. If spleen cell populations from mice stressed twice daily for 8 days were depleted of macrophages and CD4 or CD8 cells, the effect of stress on the mitogenesis was removed from the CD8 cells. Spleen cells of mice stressed for 14 days showed a decreased mitogenesis when depleted of adherent cells and reconstituted with adherent cells from control mice. Furthermore, the adherent cells from these mice had decreased ability to support mitogenesis of adherent cell-depleted spleen cells from control mice as well as a decreased IL-1 production.

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“…absorbed on 4 mg aluminium hy droxide gel (alum), following the method of Okimura et al (8). The test groups were treated with HAA (10 mg/kg, p.o.)…”

Section: Methodsmentioning

confidence: 99%

Effects of Heptaminol AMP Amidate on Suppressor and Helper Function of Murine T Cells

Saha

Ueno

Ohmori

et al. 1988

Japanese Journal of Pharmacology

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Stress and Immune Responses II. Identification of Stress-Sensitive Cells in Murine Spleen Cells

Cited by 16 publications

References 39 publications

Stress and Immune Responses IV. Adrenal Involvement in the Alteration of Antibody Responses in Restraint-Stressed Mice

Stress and Immune Responses IV. Adrenal Involvement in the Alteration of Antibody Responses in Restraint-Stressed Mice

The Effect of Various Contexts of Stress on the Mouse Spleen Lymphocytes and Macrophage Co‐stimulatory Activity

Effects of Heptaminol AMP Amidate on Suppressor and Helper Function of Murine T Cells

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