Stress and immune response in the mussel Mytilus galloprovincialis

Malagoli, Davide; Casarini, Livio; Sacchi, Sandro; Ottaviani, Enzo

doi:10.1016/j.fsi.2006.10.004

Cited by 97 publications

(67 citation statements)

References 21 publications

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“…Increased stress can result in an increase in the number of circulating haemocytes in bivalves (Renwrantz 1990, Mayrand et al 2005, Malagoli et al 2007. As eosinophilic cells are largely responsible for phagocytosis and release of reactive oxygen metabolites (Pipe et al 1997), it is assumed that an increase in immune response is directly related to the number and type of circulating cells.…”

Section: Discussionmentioning

confidence: 99%

Effects of ocean acidification on the immune response of the blue mussel Mytilus edulis

Bibby¹,

Widdicombe

Parry³

et al. 2008

Aquat. Biol.

228

148

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The effects of medium term (32 d) hypercapnia on the immune response of Mytilus edulis were investigated in mussels exposed to acidified (using CO 2 ) sea water (pH 7.7, 7.5 or 6.7; control: pH 7.8). Levels of phagocytosis increased significantly during the exposure period, suggesting an immune response induced by the experimental set-up. However, this induced stress response was suppressed when mussels were exposed to acidified sea water. Acidified sea water did not have any significant effects on other immuno-surveillance parameters measured (superoxide anion production, total and differential cell counts). These results suggest that ocean acidification may impact the physiological condition and functionality of the haemocytes and could have a significant effect on cellular signalling pathways, particularly those pathways that rely on specific concentrations of calcium, and so may be disrupted by calcium carbonate shell dissolution.

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Section: Discussionmentioning

confidence: 99%

Effects of ocean acidification on the immune response of the blue mussel Mytilus edulis

Bibby¹,

Widdicombe

Parry³

et al. 2008

Aquat. Biol.

228

148

View full text Add to dashboard Cite

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“…These animals, living in complex estuarine and intertidal environments, experience major fluctuations of physico-chemical parameters in coastal areas (GauthierClerc et al 2013;Malagoli et al 2007). In addition to those abiotic stressors, mussels house a variety of endoparasites and microbial organisms (Venier et al 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Hemocytes found in hemolymph and infiltrating tissues, constitute a heterogeneous population of immune cells actively specialized in pleiotropic defences against pathogens (Carballal et al 1997;Donaghy and Volety 2011;Le Foll et al 2010). During the inflammatory response, activated hemocytes execute several major functions of cell-mediated innate immunity, including cytotoxic production of oxygen (Costa et al 2009;Winston et al 1996) or nitrogen species (Novas et al 2007), increased production of lysozymes ) and phagocytosis (Carballal et al 1997;Garcia-Garcia et al 2008;Le Foll et al 2010;Malagoli et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Cell tracking and velocimetric parameters analysis as an approach to assess activity of mussel (Mytilus edulis) hemocytes in vitro

Rioult

Lebel²,

Foll

2013

Cytotechnology

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Hemocytes constitute the key element of innate immunity in bivalves, being responsible for secretion of antimicrobial peptides and release of zymogens from the prophenoloxidase system within the hemolymph compartment, reactive oxygen species production and phagocytosis. Hemocytes are found (and collected) as cells in suspension in circulating hemolymph. Hemocytes are adherent cells as well, infiltrating tissues and migrating to infected areas. In the present study, we applied an approach based on fluorescent staining and nuclei-tracking to determine migration velocity of hemocytes from the blue mussel, Mytilus edulis, in culture. Freshly collected hemocytes attached to substrate and start to move spontaneously in few minutes. Two main hemocyte morphologies can be observed: small star-shaped cells which were less motile and spread granular cells with faster migrations. Cell-tracking was combined to MTT mitochondria metabolic rate measurements in order to monitor global cell population activity over 4 days of culture. A transient peak of cell activity was recorded after 24-48 h of culture, corresponding to a speed up of cell migration. Videomicroscopy and cell tracking techniques provide new tools to characterize activity of mussel immunocytes in culture. Our analysis of hemocyte migration reveals that motility is very sensitive to cell environmental factors.

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“…3 It has been shown that these stressors could impact on the effectiveness of the immune system in molluscs to fight against diseases. 4 Indeed hemocytes, which are responsible for phagocytosis, are altered by various environmental factors such as salinity, temperature and pH modification, [5][6][7] by pathogens, [8][9][10] and pollution. 5,[10][11][12][13][14] Exposure to these multiple stresses affects the immune system of molluscs and could increase their susceptibility to develop infectious diseases and cancers.…”

Section: Introductionmentioning

confidence: 99%

Influence of tidal stress on the immunocompetence of hemocytes in soft-shell clam (Mya arenaria)

Beaudry¹,

Brousseau-Fournier²,

Alix³

et al. 2013

J Xenobiotics

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Stress and immune response in the mussel Mytilus galloprovincialis

Cited by 97 publications

References 21 publications

Effects of ocean acidification on the immune response of the blue mussel Mytilus edulis

Effects of ocean acidification on the immune response of the blue mussel Mytilus edulis

Cell tracking and velocimetric parameters analysis as an approach to assess activity of mussel (Mytilus edulis) hemocytes in vitro

Influence of tidal stress on the immunocompetence of hemocytes in soft-shell clam (Mya arenaria)

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