Stress and endogenous opioids: Behavioral and circulatory interactions

McCubbin, James A.

doi:10.1016/0301-0511(93)90008-v

Cited by 74 publications

(50 citation statements)

References 85 publications

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“…Our current study implies that the hippocampal kappaopioid system, known to be abnormal in the SHR model of hypertension, may also be malfunctioning in the isolation-induced IHR model. It was previously shown in humans that reactivity to stress could be increased via opioid receptor blockade with naloxone (McCubbin, 1993). This strengthens the notion that this phenomenon displayed in rats may also be pertinent to human hypertension.…”

supporting

confidence: 68%

Prevention of isolation‐induced hypertension by intrahippocampal administration of a nonpeptide kappa‐opioid receptor agonist

Wright

Ingenito

2001

Hippocampus

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Previous research in this laboratory showed that hypertension in the spontaneous hypertensive rat (SHR) appears to correlate to insufficient production of hippocampal dynorphins, and that blood pressure could be reduced by intrahippocampal administration of dynorphins and nonpeptide kappa agonists. The purpose of the present study was to investigate whether kappa agonists could prevent the development of hypertension in a different hypertensive model, i.e., the isolated male rat model of hypertension (IHR). Isolation of young male rats for 5-7 days in standard rat cages caused an increase in systolic blood pressure from a mean of 132 to 184 mmHg. The blood pressures of rats grouped 3 per cage remained stable. Rats received the nonpeptide kappa agonist U62, 066E, (Spiradoline, Upjohn), 10 nmoles/0.2 microl or drug vehicle bilaterally into the the hippocampus for 3 days prior to and during isolation or grouping. Animals treated with U62, 066E did not develop hypertension as compared to isolated animals treated with vehicle. The isolation procedure used in these studies appears to induce anxietal stress, as indicated by reduced time spent by the rats in the open arms of the elevated-plus maze. This time is increased by U62, 066E, suggesting that the drug possesses anxiolytic properties and may reduce hypertension in part, by blocking an anxiety/stress component. These data strengthen our previous findings that opioids in the hippocampus may be important in restraining increased blood pressure provoked by environmental stimuli such as isolation.

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supporting

confidence: 68%

Prevention of isolation‐induced hypertension by intrahippocampal administration of a nonpeptide kappa‐opioid receptor agonist

Wright

Ingenito

2001

Hippocampus

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“…In an extension of McCubbin's (1991;1993) model of central opioid insensitivity in the etiology of hypertension, France and Ditto (1996) proposed a model in which hypertensive hypoalgesia could be explained by one or more of three putative mechanisms: opioid dysfunction, baroreflex activation and enhanced activation of descending pain modulation systems. In humans, the evidence in favour of opioid dysfunction is mostly negative (e.g., Bruehl et al, 2002;France et al, 2005;Ring et al, 2007;Schobel et al, 1998;cf.…”

Section: Discussionmentioning

confidence: 99%

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Edwards

Ring

Al’Absi

et al. 2007

Biological Psychology

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Supraspinal pain modulation may explain hypertensive hypoalgesia. We compared nociceptive flexion reflex (NFR) thresholds and pain during rest and computer game play in hypertensives and normotensives (Experiment 1) and normotensives with and without hypertensive parents (Experiment 2). The game was selected to modulate activity in pain pathways. NFR thresholds did not differ between groups during rest or game play. Pain ratings never differed between hypertensives and normotensives, whereas individuals with hypertensive parents reported less pain during the first two NFR assessments, compared to those without. NFR thresholds and pain were reduced by game play compared to rest. The failure of game play to differentially modulate NFR thresholds or associated pain reports between groups argues against enhanced supraspinal modulation of nociception and pain in hypertensives and those at increased risk for hypertension.

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“…Notably, children with attentiondeficit/hyperactivity disorder (ADHD) also exhibit increased levels of EEG theta activity, especially during cognitive tasks (84,85), which researchers have linked with feelings of unreality (84). In a recent survey, chemically intolerant young men reported an increased rate of childhood ADHD diagnoses (86 (91). The same group of chemically intolerant elderly described above also exhibited objective polysomnographic sleep patterns such as decreased total sleep time, increased waking, and decreased rapid-eye movement sleep, despite only slightly elevated subjective ratings of sleep disturbance compared with chemically tolerant controls (92).…”

Section: Time-dependent Sensitizationmentioning

confidence: 99%

Individual differences in neural sensitization and the role of context in illness from low-level environmental chemical exposures.

Bell

Schwartz

Baldwin

et al. 1997

Environ Health Perspect

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Stress and endogenous opioids: Behavioral and circulatory interactions

Cited by 74 publications

References 85 publications

Prevention of isolation‐induced hypertension by intrahippocampal administration of a nonpeptide kappa‐opioid receptor agonist

Prevention of isolation‐induced hypertension by intrahippocampal administration of a nonpeptide kappa‐opioid receptor agonist

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Individual differences in neural sensitization and the role of context in illness from low-level environmental chemical exposures.

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