Stress and development of depression and heavy drinking in adulthood: moderating effects of childhood trauma

Colman, Ian; Garad, Yasmin; Zeng, Yiye; Naicker, Kiyuri; Weeks, Murray; Patten, Scott B.; Jones, Peter B.; Thompson, Aiko K.; Wild, T. Cameron

doi:10.1007/s00127-012-0531-8

Cited by 38 publications

(33 citation statements)

References 40 publications

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“…This suggests that stress exposure could increase the risk of consuming more alcohol among previous regular users consistent with reviews on the effect of stress on continuation of alcohol use (162). On the other hand, some studies reported no relationships between stressful events and drinking patterns: recent life stress did not predict drinking patterns when also accounting for childhood trauma (143) or sex (146); this latter study found stressful events to relate to more heavy drinking in men, whereas in women more heavy drinking related to stressful events only in those with a history of childhood trauma.…”

Section: Effects Of Trauma or Stress On Stages Of The Addiction Cyclecontrasting

confidence: 64%

“…Childhood trauma increases risk to develop a substance use disorder (12–15, 17–20, 23, 78, 86, 93, 143, 144), including for nicotine, alcohol, marijuana, stimulants, sedatives, and opioids, but not cocaine (120). In addition, a history of childhood sexual, physical, or emotional abuse was related to heavier or more frequent alcohol or substance use in adults across substance use disorders (22, 88, 93), although other studies did not find this (89).…”

Section: Effects Of Trauma or Stress On Stages Of The Addiction Cyclementioning

confidence: 99%

“…In addition, a history of childhood sexual, physical, or emotional abuse was related to heavier or more frequent alcohol or substance use in adults across substance use disorders (22, 88, 93), although other studies did not find this (89). Risk to use any licit or illicit drugs (4) and the severity of heavy drinking (143) and nicotine dependence (93) increased with severity of childhood trauma. Interestingly, the relationship between childhood trauma and substance use disorder could be mediated by increased trait impulsivity (22) or subsequent stressful events in adolescence or adulthood (145, 146), suggesting that the risk to develop a substance use disorder among people with a history of childhood sexual abuse or other trauma is greater in those with higher impulsivity or those who encounter additional stressful events.…”

Section: Effects Of Trauma or Stress On Stages Of The Addiction Cyclementioning

confidence: 99%

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Stress Modulates Illness-Course of Substance Use Disorders: A Translational Review

Lijffijt

Swann

2014

Front. Psychiatry

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Childhood trauma and post-childhood chronic/repeated stress could increase the risk of a substance use disorder by affecting five stages of addiction illness-course: (a) initial experimentation with substances; (b) shifting from experimental to regular use; (c) escalation from regular use to abuse or dependence; (d) motivation to quit; and (e) risk of (re-)lapse. We reviewed the human literature on relationships between stress and addiction illness-course. We explored per illness-course stage: (i) whether childhood trauma and post-childhood chronic/repeated stress have comparable effects and (ii) whether effects cut across classes of substances of abuse. We further discuss potential underlying mechanisms by which stressors may affect illness-course stages for which we relied on evidence from studies in animals and humans. Stress and substances of abuse both activate stress and dopaminergic motivation systems, and childhood trauma and post-childhood stressful events are more chronic and occur more frequently in people who use substances. Stressors increase risk to initiate early use potentially by affecting trait-like factors of risk-taking, decision making, and behavioral control. Stressors also accelerate transition to regular use potentially due to prior effects of stress on sensitization of dopaminergic motivation systems, cross-sensitizing with substances of abuse, especially in people with high trait impulsivity who are more prone to sensitization. Finally, stressors increase risk for abuse and dependence, attenuate motivation to quit, and increase relapse risk potentially by intensified sensitization of motivational systems, by a shift from positive to negative reinforcement due to sensitization of the amygdala by corticotropin releasing factor, and by increased sensitization of noradrenergic systems. Stress generally affects addiction illness-course across stressor types and across classes of substances of abuse.

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Section: Effects Of Trauma or Stress On Stages Of The Addiction Cyclecontrasting

confidence: 64%

Section: Effects Of Trauma or Stress On Stages Of The Addiction Cyclementioning

confidence: 99%

Section: Effects Of Trauma or Stress On Stages Of The Addiction Cyclementioning

confidence: 99%

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Stress Modulates Illness-Course of Substance Use Disorders: A Translational Review

Lijffijt

Swann

2014

Front. Psychiatry

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“…Using similar definitions as previous studies using NPHS data, 17 we defined several types of stressors: childhood trauma, recent marital problems, recent unemployment, recent household financial problems, work stress, chronic stress and change in social support. Childhood trauma was assessed in Cycle 1 (1994/1995) for those 18 or older at that time, and in Cycle 4 (2000/2001) for the rest of our cohort.…”

Section: Stressorsmentioning

confidence: 99%

The contribution of stress to the comorbidity of migraine and major depression: results from a prospective cohort study

et al. 2013

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ObjectivesTo assess how much the association between migraine and depression may be explained by various measures of stress.DesignNational Population Health Survey is a prospective cohort study representative of the Canadian population. Eight years of follow-up time were used in the present analyses.SettingCanadian adult population ages 18–64.Participants9288 participants.OutcomeIncident migraine and major depression.ResultsAdjusting for sex and age, depression was predictive of incident migraine (HR: 1.62; 95% CI 1.03 to 2.53) and migraine was predictive of incident depression (HR: 1.55; 95% CI 1.15 to 2.08). However, adjusting for each assessed stressor (childhood trauma, recent marital problems, recent unemployment, recent household financial problems, work stress, chronic stress and change in social support) decreased this association, with chronic stress being a particularly strong predictor of outcomes. When adjusting for all stressors simultaneously, both associations were largely attenuated (depression–migraine HR: 1.30; 95% CI 0.80 to 2.10; migraine–depression HR: 1.19; 95% CI 0.86 to 1.66).ConclusionsMuch of the apparent association between migraine and depression may be explained by stress.

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“…For example, it increases the risk of psychiatric disorders such as depression [1,[3][4][5], bipolar disorder [6], post-traumatic stress disorder [1,4] and suicide attempts [1,4], as well as alcohol use disorder (AUD) [1,3,7,8]. The prevalence of traumatic experiences in childhood has been found to be very high in patients with AUD.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Childhood Maltreatment on Age of Onset of Alcohol Use Disorder in Women

et al. 2018

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It is unclear whether exposure to childhood maltreatment is associated with the age of onset of alcohol use disorder (AUD). A group of socially stable women with AUD seeking treatment (n = 75) were interviewed using the Addiction Severity Index and the Mini International Neuropsychiatric Interview. They also filled out the Childhood Trauma Questionnaire-short form. Emotional abuse, sexual abuse and multiple childhood traumas were found to be associated with earlier onset of AUD. Multivariable linear regression analysis showed that independent predictors for an earlier onset of AUD were exposure to emotional abuse (beta = –7.44, SE = 2.83, adjusted p = 0.010) and mother’s alcohol/substance problems (beta = –7.87, SE = 3.45, adjusted p = 0.026). These variables explained 18.9% of the variance of age of onset of AUD. These findings highlight a need for increased clinical attention to AUD subgroups who have experienced childhood maltreatment, especially emotional abuse, as well as a need for including support in the patient’s own parental role in the treatment.

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Stress and development of depression and heavy drinking in adulthood: moderating effects of childhood trauma

Abstract: Childhood trauma increases risk for both depression and heavy drinking. Trauma may moderate the effect of stress on depression; the relationship among trauma, stress and heavy drinking is less clear.

Cited by 38 publications

References 40 publications

Stress Modulates Illness-Course of Substance Use Disorders: A Translational Review

Stress Modulates Illness-Course of Substance Use Disorders: A Translational Review

The contribution of stress to the comorbidity of migraine and major depression: results from a prospective cohort study

The Impact of Childhood Maltreatment on Age of Onset of Alcohol Use Disorder in Women

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