Stress and cancer: The mechanisms of immune dysregulation and management

Liu, Yixin; Sheng, Tian; Ning, Biao; Huang, Tianhe; Li, Yang; Wei, Yongchang

doi:10.3389/fimmu.2022.1032294

Cited by 10 publications

(2 citation statements)

References 178 publications

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“…Conventional anticancer therapies like chemotherapy, radiotherapy, surgery, and molecularly targeted therapies have all strived to correct this dysregulation of the stress‐immunity cycle by killing cancer cells and reduce tumor burden 8–10 . Unfortunately, over the last decades, these conventional anticancer therapies have achieved limited success in meaningfully prolonging the survival of patients.…”

Section: Introductionmentioning

confidence: 99%

“…7 Conventional anticancer therapies like chemotherapy, radiotherapy, surgery, and molecularly targeted therapies have all strived to correct this dysregulation of the stress-immunity cycle by killing cancer cells and reduce tumor burden. [8][9][10] Unfortunately, over the last decades, these conventional anticancer therapies have achieved limited success in meaningfully prolonging the survival of patients. This is due to both primary and acquired resistance of cancer cells against these therapies as well as their inability to properly reactivate our immune system against (residual) cancer cells.…”

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confidence: 99%

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The cell stress and immunity cycle in cancer: Toward next generation of cancer immunotherapy

Laureano,

Vanmeerbeek,

Sprooten

et al. 2023

Immunological Reviews

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SummaryThe cellular stress and immunity cycle is a cornerstone of organismal homeostasis. Stress activates intracellular and intercellular communications within a tissue or organ to initiate adaptive responses aiming to resolve the origin of this stress. If such local measures are unable to ameliorate this stress, then intercellular communications expand toward immune activation with the aim of recruiting immune cells to effectively resolve the situation while executing tissue repair to ameliorate any damage and facilitate homeostasis. This cellular stress‐immunity cycle is severely dysregulated in diseased contexts like cancer. On one hand, cancer cells dysregulate the normal cellular stress responses to reorient them toward upholding growth at all costs, even at the expense of organismal integrity and homeostasis. On the other hand, the tumors severely dysregulate or inhibit various components of organismal immunity, for example, by facilitating immunosuppressive tumor landscape, lowering antigenicity, and increasing T‐cell dysfunction. In this review we aim to comprehensively discuss the basis behind tumoral dysregulation of cellular stress‐immunity cycle. We also offer insights into current understanding of the regulators and deregulators of this cycle and how they can be targeted for conceptualizing successful cancer immunotherapy regimen.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

The cell stress and immunity cycle in cancer: Toward next generation of cancer immunotherapy

Laureano,

Vanmeerbeek,

Sprooten

et al. 2023

Immunological Reviews

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Metalloproteinases as Biomarkers and Sociomarkers in Human Health and Disease

Costa,

Scalise,

Ielapi

et al. 2024

Biomolecules

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Metalloproteinases (MPs) are zinc-dependent enzymes with proteolytic activity and a variety of functions in the pathophysiology of human diseases. The main objectives of this review are to analyze a specific family of MPs, the matrix metalloproteinases (MMPs), in the most common chronic and complex diseases that affect patients’ social lives and to better understand the nature of the associations between MMPs and the psychosocial environment. In accordance with the PRISMA extension for a scoping review, an examination was carried out. A collection of 24 studies was analyzed, focusing on the molecular mechanisms of MMP and their connection to the manifestation of social aspects in human disease. The complexity of the relationship between MMP and social problems is presented via an interdisciplinary approach based on complexity paradigm as a new approach for conceptualizing knowledge in health research. Finally, two implications emerge from the study: first, the psychosocial states of individuals have a profound impact on their overall health and disease conditions, which implies the importance of adopting a holistic perspective on human well-being, encompassing both physical and psychosocial aspects. Second, the use of MPs as biomarkers may provide physicians with valuable tools for a better understanding of disease when used in conjunction with “sociomarkers” to develop mathematical predictive models.

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Colorectal Cancer Surgery: Influence of Psychosocial Factors

Moldes-Moro,

de Dios-Duarte

2023

Cancers

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(1) Background: In the treatment of colorectal cancer, it is important to consider different psychosocial factors. Our first objective was to measure the levels of perceived stress in subjects diagnosed with colorectal cancer awaiting potentially curative surgery. Also, we aimed to analyse what coping styles these patients used, how they perceived their illness, and the subsequent influence of these factors on their levels of stress. (2) Methods: Stress, coping styles and illness perception were assessed in a sample of 107 patients. The instruments used were the Perceived Stress Scale (PSS-14), the Stress Coping Questionnaire (SCQ) and the Brief Illness Perception Questionnaire (BIPQ-R). (3) Results: Patients using active coping styles have lower levels of perceived stress (p = 0.000; p = 0.002) than patients making use of passive coping styles (p = 0.000; p = 0.032; p = 0.001). A multi-linear regression model found that the perception of illness and the use of the negative approach coping style (p = 0.000; p = 0.001) influence an increase in perceived stress, and that a decrease in stress levels was influenced by the problem solving coping style (p = 0.001). (4) Conclusions: Based on our results, we recommend preventive interventions in care patients undergoing colorectal cancer surgery.

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Stress and cancer: The mechanisms of immune dysregulation and management

Cited by 10 publications

References 178 publications

The cell stress and immunity cycle in cancer: Toward next generation of cancer immunotherapy

The cell stress and immunity cycle in cancer: Toward next generation of cancer immunotherapy

Metalloproteinases as Biomarkers and Sociomarkers in Human Health and Disease

Colorectal Cancer Surgery: Influence of Psychosocial Factors

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