Stress and Alcohol Cues Exert Conjoint Effects on Go and Stop Signal Responding in Male Problem Drinkers

Zack, Martin; Woodford, Tracy M.; Tremblay, Anne M; Steinberg, Lindsay; Zawertailo, Laurie; Busto, Usoa E.

doi:10.1038/npp.2010.177

Cited by 23 publications

(24 citation statements)

References 94 publications

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“…This slower reaction time may represent a conflict during prepotent response inhibition resulting in response delays, consistent with previous reports (Zack et al, 2011). Nonsignificant differences in error proportion between groups further improves our interpretation of fMRI response differences seen in this study, as the data suggest that the two groups are matched on task performance at a behavioral level.…”

Section: Go/no-go Behavioral Performance and Fmri Activitysupporting

confidence: 91%

Influence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers

Ahmadi

Pearlson

Meda

et al. 2013

Neuropsychopharmacol

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Impaired inhibition of prepotent motor response may represent an important risk factor for alcoholism. Alcohol use may also increase impulsive behavior, including impaired response inhibition. Little is known about the brain function underlying response inhibition among college-age drinkers based on their drinking patterns, despite college-age drinkers demonstrating high rates of alcohol-use disorders. Our major objective was to compare behavior and associated brain activity measured with fMRI during a response-inhibition task in matched heavy-and light-alcohol-drinking college students. Participants were light (N ¼ 36) and heavy (N ¼ 56) drinkers, aged 18-20 years. We characterized blood oxygen level-dependent (BOLD) responses, while participants performed an fMRI Go/No-Go task to quantify inhibitory behavior and brain activity. Behaviorally, group performance differences were observed for Go correct-hit and No-Go falsealarm reaction times with increased reaction times in heavy compared with light drinkers. During fMRI No-Go correct rejections, light drinkers exhibited greater BOLD response than did heavy drinkers in left supplementary motor area (SMA), bilateral parietal lobule, right hippocampus, bilateral middle frontal gyrus, left superior temporal gyrus, and cingulate gyrus/anterior cingulate cortex (Brodmann area 24). Group differences in Go/No-Go-related regional activations correlated with alcohol-and impulsivity-related measures. These findings suggest that heavy alcohol drinkers may have dysfunction in brain regions underlying attention and response inhibition, leading to diminished abilities to suppress prepotent responding. The extent to which these tendencies relate to impulsive decision-making and behaviors in real-life settings and may guide intervention development warrants additional investigation.

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Section: Go/no-go Behavioral Performance and Fmri Activitysupporting

confidence: 91%

Influence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers

Ahmadi

Pearlson

Meda

et al. 2013

Neuropsychopharmacol

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“…Using functional MR imaging, we asked whether negative semantic priming of emotion and alcohol-related conflict could promote inhibition of alcohol-related information in chronic alcoholics and enable neural activation of executive control functions similar to that of controls (Kamarajan et al 2005; Lawrence et al 2009; Zack et al 2011). We had previously observed a predominant midbrain-limbic activation in ALC in contrast to a frontoparietal activation in controls during the processing of alcohol- and emotion-related conflict using an alcohol-emotion Stroop Match-to-Sample task (Müller-Oehring et al 2013) that was similar to the one used in this study but without semantic priming.…”

Section: Discussionmentioning

confidence: 99%

The neural correlates of priming emotion and reward systems for conflict processing in alcoholics

Schulte

Jung

Sullivan

et al. 2016

Brain Imaging and Behavior

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Emotional dysregulation in alcoholism (ALC) may result from disturbed inhibitory mechanisms. We therefore tested emotion and alcohol cue reactivity and inhibitory processes using negative priming. To test the neural correlates of cue reactivity and negative priming, 26 ALC and 26 age-matched controls underwent functional MRI performing a Stroop color match-to-sample task. In cue reactivity trials, task-irrelevant emotion and alcohol-related pictures were interspersed between color samples and color words. In negative priming trials, pictures primed the semantic content of an alcohol or emotion Stroop word. Behaviorally, both groups showed response facilitation to picture cue trials and response inhibition to primed trials. For cue reactivity to emotion and alcohol pictures, ALC showed midbrain-limbic activation. By contrast, controls activated frontoparietal executive control regions. Greater midbrain-hippocampal activation in ALC correlated with higher amounts of lifetime alcohol consumption and higher anxiety. With negative priming, ALC exhibited frontal cortical but not midbrain-hippocampal activation, similar to the pattern observed in controls. Higher frontal activation to alcohol-priming correlated with less craving and to emotion-priming with fewer depressive symptoms. The findings suggest that neurofunctional systems in ALC can be primed to deal with upcoming emotion- and alcohol-related conflict and can overcome the prepotent midbrain-limbic cue reactivity response.

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“…In a separate study in which pharmacological stressors were used, a similar result was found (Schwabe et al 2010). In a study with male problem drinkers, a stressor increased a pre-existing bias to alcohol vs. neutral words (Zack et al 2010). The results of these studies suggest that stress either promotes habitual responses, impedes ability to employ conscious processes to counter responding based on habit, or both.…”

Section: Discussionmentioning

confidence: 99%

An acute psychosocial stressor increases drinking in non-treatment-seeking alcoholics

et al. 2011

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Rationale-Although studies suggest that stress is an important reason for relapse in alcoholics, few controlled studies have been conducted to examine this assumption. Evidence of stresspotentiated drinking would substantiate this clinical observation and would contribute to the development of a model that would be valuable to alcohol treatment research.Objectives-The hypothesis was tested that an acute psychosocial stressor, the Trier Social Stress Test (TSST), increases alcohol consumption in non-treatment-seeking alcoholics.Methods-Seventy-nine alcohol-dependent participants (40 women) were randomly assigned to receive the TSST or a no-stress condition. Immediately afterward, all participants received an initial dose of their preferred alcoholic beverage to achieve a target blood alcohol concentration of 0.03 g/dl (to prime subsequent drinking in the laboratory). Participants then participated in a mock taste test of two glasses of beer. Primary dependent measures were whether s/he drank all of the beer available (yes/no) and total amount of beer consumed (milliliters).Results-Stressed participants were twice as likely as non-stressed participants to drink all of the beer available, a significant effect. Although the stressed group drank more milliliters than the non-stressed group, this effect failed to reach significance, likely due to ceiling effects. There were no significant stress group × gender effects on either outcome.Conclusions-This study supports that stress-potentiated drinking is valid and can be modeled in a clinical laboratory setting. KeywordsAlcohol; Relapse; Cortisol; Stress; Gender; Model Stress is broadly defined as a process by which a stimulus elicits an emotional, behavorial, and/or physiologic response (Ice and James 2007). That experiences interpreted as stressful can induce drinking is implicit in theories regarding the development and maintenance of alcohol use disorders (Conger 1951;Sayette 1993;Sher and Levenson 1982) and relapse (Marlatt and Gordon 1985;Zywiak et al. 1996). Several clinical studies report that relapse is attributed to stressful life events and/or one's ability to cope with stress (Brown et al. 1995;Levy 2008;Vuchinich and Tucker 1996). Not surprisingly, most evidence-based treatments for alcohol dependence include stress-coping and mood management elements to help © Springer-Verlag 2011 Correspondence to: Suzanne E. Thomas, thomass@musc.edu. Disclosures/conflict of interest The authors declare no conflicts of interest. NIH Public AccessAuthor Manuscript Psychopharmacology (Berl). Author manuscript; available in PMC 2012 November 1. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript treatment seekers maintain sobriety (Marlatt and Gordon 1985;Monti et al. 2002;Vieten et al. 2010).Although there is substantial clinical and anecdotal support for stress-induced relapse, determining conclusively that stress causes drinking is a challenge. To do so, randomized controlled studies are needed where individuals are exposed (or not) to a ...

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Stress and Alcohol Cues Exert Conjoint Effects on Go and Stop Signal Responding in Male Problem Drinkers

Cited by 23 publications

References 94 publications

Influence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers

Influence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers

The neural correlates of priming emotion and reward systems for conflict processing in alcoholics

An acute psychosocial stressor increases drinking in non-treatment-seeking alcoholics

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