Stress and adult neurogenesis

Mirescu, Christian; Gould, Elizabeth

doi:10.1002/hipo.20155

Cited by 602 publications

(429 citation statements)

References 74 publications

Supporting

Mentioning

406

Contrasting

Unclassified

Order By: Relevance

“…In contrast to other examples of regulated neurogenesis that occur quickly after the stimulus, e.g., up-regulation after voluntary wheel running (39) or down-regulation after stress (40), in this study we find the consequences of discontinuing immunological support for baseline neurogenesis.…”

Section: Discussioncontrasting

confidence: 99%

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

Wolf

Steiner

Akpinarli

et al. 2009

The Journal of Immunology

272

235

View full text Add to dashboard Cite

Adult hippocampal neurogenesis occurs in an exceptional permissive microenvironment. Neuroimmunological mechanisms might be prominently involved in the endogenous homeostatic principles that control baseline levels of adult neurogenesis. We show in this study that this homeostasis is partially dependent on CD4-positive T lymphocytes. Systemic depletion of CD4-positive T lymphocytes led to significantly reduced hippocampal neurogenesis, impaired reversal learning in the Morris water maze, and decreased brain-derived neurotrophic factor expression in the brain. No such effect of CD8 or B cells was observed. Repopulation of RAG2−/− mice with CD4, but not with CD8 cells again increased precursor cell proliferation. The T cells in our experiments were non-CNS specific and rarely detectable in the healthy brain. Thus, we can exclude cell-cell contacts between immune and brain cells or lymphocyte infiltration into the CNS as a prerequisite for an effect of CD4-T cells on neurogenesis. We propose that systemic CD4-T cell activity is required for maintaining cellular plasticity in the adult hippocampus and represents an evolutionary relevant communication route for the brain to respond to environmental changes.

show abstract

Section: Discussioncontrasting

confidence: 99%

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

Wolf

Steiner

Akpinarli

et al. 2009

The Journal of Immunology

272

235

View full text Add to dashboard Cite

show abstract

“…Thus, neurogenesis is a structural event that may have functional consequences. Indeed, emerging evidence suggests that hippocampal neurogenesis may be functionally linked to stress and mood disorders (Dranovsky and Hen, 2006;Malberg and Blendy, 2005;Mirescu and Gould, 2006;Warner-Schmidt andDuman, 2006) cf. (Henn andVollmayr, 2004).…”

Section: Discussionmentioning

confidence: 99%

Abstinence following Alcohol Drinking Produces Depression-Like Behavior and Reduced Hippocampal Neurogenesis in Mice

Stevenson

Schroeder

Nixon

et al. 2008

Neuropsychopharmacol

130

102

View full text Add to dashboard Cite

Alcoholism and depression show high degrees of comorbidity. Clinical evidence also indicates that depression that emerges during abstinence from chronic alcohol use has a greater negative impact on relapse than pre-existing depression. Although no single neurobiological mechanism can account for the behavioral pathologies associated with these devastating disorders, converging evidence suggests that aspects of both alcoholism and depression are linked to reductions in hippocampal neurogenesis. Here, we report results from a novel preclinical behavioral model showing that abstinence from voluntary alcohol drinking leads to the emergence of depressionlike behavior and reductions in neurogenesis. C57BL/6J mice were allowed to self-administer ethanol (10% v/v) vs H 2 O in the home cage for 28 days. Alcohol was then removed for 1 or 14 days, and mice were tested in the forced swim test to measure depression-like behavior. After 14 days, but not 1 day of abstinence from alcohol drinking, mice showed a significant increase in depression-like behavior. The significant increase in depression-like behavior during abstinence was associated with a reduction in proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) immunoreactivity in the dentate gyrus of the hippocampus indicating that both the number of proliferating neural progenitor cells (NPC) and immature neurons were reduced, respectively. The number of NPCs that were labeled with bromo-deoxyuridine (BrdU) at the beginning of alcohol exposure was not altered indicating that survival of NPCs is not linked to abstinence-induced depression. Chronic treatment (14 days) with the antidepressant desipramine during abstinence prevented both the emergence of depression-like behavior and the reduction in hippocampal neurogenesis indicating that abstinence-induced depression is associated with structural plasticity in the hippocampus. Overall, the results of this study support the conclusion that profound functional (ie behavioral) and structural changes occur during abstinence from alcohol use and suggest that antidepressant treatment may alleviate some of these pathological neurobehavioral adaptations.

show abstract

“…It is estimated that about 800-1,600 new neurons are generated everyday in the dentate gyrus of a mouse McKay, 2001, Hayes andNowakowski, 2002). Although the functional significance is still not clear, accumulating evidence has indicated that neurogenesis may play an important role in the maintenance of normal hippocampal functions such as learning and memory (van Praag, et al, 2000, Shors, et al, 2001, Aimone, et al, 2006 and may be modulated by environmental factors (Kempermann, et al, 1997, Rampon, et al, 2000, van Praag, et al, 2000, stress (Mirescu andGould, 2006, Warner-Schmidt andDuman, 2006) and antidepressants (Santarelli, et al, 2003, Duman, 2004. Moreover, certain acute brain injuries such as ischemia, hypoxia, seizures, and trauma increase neurogenesis (Kokaia and Lindvall, 2003, Rice, et al, 2003, Itoh, et al, 2005, Overstreet-Wadiche, et al, 2006, Qiu, et al, 2007, suggesting that neurogenesis may work as a protective mechanism for the brain.…”

Section: Introductionmentioning

confidence: 99%

Adult neurogenesis is functionally associated with AD-like neurodegeneration

Chen

Nakajima

Choi

et al. 2008

Neurobiology of Disease

View full text Add to dashboard Cite

Alzheimer's disease (AD) is predominantly characterized by progressive neuronal loss in the brain. It has been recently found that adult neurogenesis in the hippocampal dentate gyrus of AD patients is significantly enhanced, while its functional significance is still unknown. By using an AD-like neurodegeneration mouse model, we show here that neurogenesis in the dentate gyrus was neurodegenerative stage-dependent. At early stages of neurodegeneration, neurogenesis was significantly enhanced and newly generated neurons migrated into the local neuronal network. Up to late stages of neurodegeneration, however, the survival of newly generated neurons was impaired so that the enhanced neurogenesis could not be detected any more. Most interestingly, these dynamic changes in neurogenesis were correlated with the severity of neuronal loss in the dentate gyrus, indicating that neurogenesis may work as a self-repairing mechanism to compensate for neurodegeneration. Therefore, to enhance endogenous neurogenesis at early stages of neurodegeneration may be a valuable strategy to delay neurodegenerative progress.

show abstract

Stress and adult neurogenesis

Cited by 602 publications

References 74 publications

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

Abstinence following Alcohol Drinking Produces Depression-Like Behavior and Reduced Hippocampal Neurogenesis in Mice

Adult neurogenesis is functionally associated with AD-like neurodegeneration

Contact Info

Product

Resources

About