Streptozotocin-induced diabetes in the spontaneously hypertensive rat

Somani, Pitambar; Singh, Harwinder; Saini, R. K.; Rabinovitch, Alex

doi:10.1016/0026-0495(79)90144-6

Cited by 51 publications

(27 citation statements)

References 11 publications

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“…This elevated BP was associated with the presence of high levels of urinary and blood glucose in diabetic rats. These findings correlate with other investigators (13)(14)(15)(16). Also, LVWT was increased in the diabetic rats.…”

Section: Discussionsupporting

confidence: 93%

The Effects of Captopril on Cardiac Regression, Blood Pressure and Bradykinin Components in Diabetic Wistar Kyoto Rats

Sharma

Kesavarao

2011

Int J Immunopathol Pharmacol

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Section: Discussionsupporting

confidence: 93%

The Effects of Captopril on Cardiac Regression, Blood Pressure and Bradykinin Components in Diabetic Wistar Kyoto Rats

Sharma

Kesavarao

2011

Int J Immunopathol Pharmacol

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“…At these doses, STZ has been shown to induce marked hyperglycemic effects (blood glucose >300 mg/dl) in these rats. 9 STZ (Sigma Chemical, St. Louis, MO, USA) was dissolved in 0.9% NaCl solution containing 1 mM citrate buffer (pH 4.5) immediately before use, at a volume of 1 ml/kg body weight. Solvent was injected into the control WKY and SHR.…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, some reports do not support the existence of hypertension in STZ-diabetic rats. 78 Somani et al 9 reported that blood pressure (BP) in Wistar-Kyoto rats (WKY) rises progressively with increasing dose of STZ, whereas STZ induces a dose-dependent decrease of BP in spontaneously hypertensive rats (SHR). Rodgers et al 10 reported that STZ induces a depressor effect in SHR and has no effect in WKY.…”

mentioning

confidence: 99%

Does so-called streptozocin hypertension exist in rats?

1987

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SUMMARY Although the existence of so-called streptozocin hypertension seems well established, some reports have indicated that no rise in blood pressure (BP) occurred after streptozocin treatments. To ascertain the streptozocin-induced BP response, normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were treated with streptozocin, 40 to 45 and 35 mg/kg i. v., respectively, and BP was determined directly and indirectly every week for 3 to 4 weeks. Direct mean BP was determined without anesthesia or restraint through a cannula inserted into the rat's abdominal aorta. Indirect BP was determined at the tail without anesthesia after prewarming the rat in a holder. Compared with control values, indirect BP increased significantly in diabetic WKY 2 weeks after streptozocin treatment. In contrast, direct BP of these rats decreased, compared with control values. Indirect BP of diabetic SHR was as high as that of the controls, whereas direct BP of diabetic SHR decreased significantly 1 week after the treatment and thereafter, compared with control values. These discrepancies between the direct and indirect BP values may be caused by severe emaciation of diabetic rats. Extra pressure in the cuff may be necessary to occlude the bloodstream. These results indicate that under these conditions the value of BP obtained by the direct measurement is more reliable than that by the indirect one; therefore, we concluded that so-called streptozocin hypertension does not exist. (Hypertension 10: 517-521, 1987 Received May 20, 1987; accepted June 25, 1987. been suggested to play a role in the development of hypertension in STZ-induced diabetic rats. On the other hand, some reports do not support the existence of hypertension in STZ-diabetic rats. 78 Somani et al. 9 reported that blood pressure (BP) in Wistar-Kyoto rats (WKY) rises progressively with increasing dose of STZ, whereas STZ induces a dose-dependent decrease of BP in spontaneously hypertensive rats (SHR). Rodgers et al. 10 reported that STZ induces a depressor effect in SHR and has no effect in WKY. Of these groups, 1 " 10 only two tried to determine BP directly. 3 -9 All other groups determined BP using the indirect tailcuff measurement. In a previous study, in which we tried to develop an animal model of hypertension with diabetes mellitus, we found a discrepancy between BP values determined by direct cannulation and the indirect tail-cuff method.11 In Wistar rats, WKY, and SHR treated with STZ (30-80 mg/kg i.v.), the indirect BP measurement yielded hypertensive values whereas rather low BP values were obtained by the direct measurement.11 To our knowledge, no previous study has conducted parallel determinations of direct and indirect BP in STZ-

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“…[34] SHR rats are hyperactive, [36,74] and findings of reduced body weight and plasma insulin levels compared to WKY rats were consistent with prior reports. [34, 75,76] SHR rats also showed progressively developing NCV deficits and attenuated axonal radial growth in the sciatic and sural nerves, without myelinated fiber loss or any change in fiber density. These features have been previously reported, [34,77] along with generalized myelin thinning in formalin-fixed paraffin embedded sections.…”

Section: Figure 2 A-fmentioning

confidence: 85%

An Update On Rodent Model Studies In Diabetic Neuropathy: A Brief Communication

Lima¹,

Vasconcelos²,

Júnior³

et al. 2016

Int Arch Med

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The diseases of the peripheral nerves are quite common and diversified, are directly related to several factors, ranging from the imbalance related to good nutrition and adequate needs of nutrients, going to the injuries caused by drugs or mechanisms external to the human organism. Diabetes is a complex syndrome that affects and kills millions of people worldwide. We demonstrated through the experimental model of diabetes using STZ@ in single intraperitoneal dose of 60 mg / kg, that both a purely motor nerve can be directly affected as well as a special afferent nerve (cranial nerve), this comparison showed us that there is a possibility of having a new type of mixed type neuropathy, this may be related to the amount of the dose involved, such as the time of disease progression, but more studies need to be done for definitive confirmation. We can extrapolate the original results to understand the mechanisms of diabetes in humans, although it does not yet have an experimental model of type II diabetes, more related to eating disorders, the STZ application simulates the effects of type I or insulin dependent diabetes, with more serious and deleterious effects mainly the more distal portions of the nerves. Prevention and food control are very important, especially those related to the mechanisms that involve carbohydrate metabolism and its peripheral resistance. The original results commented here are relevant for the continuous study of this serious but old illness, but quite current in the medical and therapeutic clinic.

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Streptozotocin-induced diabetes in the spontaneously hypertensive rat

Cited by 51 publications

References 11 publications

The Effects of Captopril on Cardiac Regression, Blood Pressure and Bradykinin Components in Diabetic Wistar Kyoto Rats

The Effects of Captopril on Cardiac Regression, Blood Pressure and Bradykinin Components in Diabetic Wistar Kyoto Rats

Does so-called streptozocin hypertension exist in rats?

An Update On Rodent Model Studies In Diabetic Neuropathy: A Brief Communication

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