Streptozotocin-induced diabetes in rats is associated with impaired metabolic availability of vitamin A (retinol)

Tuitoek, Prisca J.; Ziari, S.; Tsin, Andrew; Rajotte, Ray V.; Suh, Miyoung; Basu, Tapan K.

doi:10.1079/bjn19960164

Cited by 58 publications

(60 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other investigators found that retinol concentrations were signi®cantly decreased in Type 1 (Krempf et al, 1991) and increased in Type 2 diabetes mellitus as compared to control subjects (Krempf et al, 1991;Havivi et al, 1991;Sasaki et al, 1995). Tuitoek et al (1996) reported signi®-cantly lower plasma concentrations of retinol in STZdiabetic Wistar rats which is thought to be a response to diabetes since signi®cantly lower plasma retinol concentrations were also found in pair-feeding and in vitamin A supplemented diabetic rats.…”

Section: Introductionmentioning

confidence: 96%

Retinol, α-tocopherol and carotenoids in diabetes

et al. 1999

View full text Add to dashboard Cite

Objective: A case-control study was conducted to evaluate the effects of diabetes mellitus on serum levels of vitamin A, a-carotene, b-carotene, a-tocopherol, serum and urine RBP. Subjects: One hundred and seven patients with Type 2 diabetes mellitus (28 ± 74 y) were recruited from those attending a primary health care clinic in King Khalid University Hospital in Riyadh City (Saudi Arabia). They were matched for age and sex with 143 healthy individuals. Methods: Fasting blood samples and 10 h urine collections were obtained from all subjects. Levels of vitamins and carotenoids in serum measured by high performance liquid chromatography (HPLC), and of retinol binding protein (RBP) in serum and urine by an enzyme-linked immunosorbent assay (ELISA). Results: The mean serum concentrations of retinol, a-carotene, and a-tocopherol were similar in both groups after correction of lipid soluble vitamins for serum lipids levels. However, serum b-carotene concentration was signi®cantly higher in control subjects than diabetics (P 0.002). Serum and urine RBP concentrations were signi®cantly higher in diabetics than in controls (P 0.0001 ). In normal subjects (but not diabetics) serum concentrations of retinol and RBP were higher in men than in women (P 0.02, P 0.0001 respectively). In both normal and diabetic subjects, serum levels of a-tocopherol (P 0.007) and urine RBP (P 0.005), were higher in men than women. Urinary excretion of RBP was signi®cantly higher in diabetic patients with renal impairment than other diabetics or controls (P 0.0001). There was a negative correlation between fasting blood glucose (FBG) concentration and serum b-carotene (P 0.008) in the total combined group and a positive correlation between FBG and urinary RBPacreatinine (P 0.009) in diabetic patients. Conclusion: Serum b-carotene concentration was signi®cantly lower in diabetic patients than controls. Serum retinol concentration in patients with diabetes was normal, yet serum and urine RBP concentrations were signi®cantly higher in diabetics than in controls. Sponsorship: The research was sponsored by King Faisal Specialist Hospital and Research Center.

show abstract

Section: Introductionmentioning

confidence: 96%

Retinol, α-tocopherol and carotenoids in diabetes

et al. 1999

View full text Add to dashboard Cite

show abstract

“…Although several studies currently focus on the relation between RBP and diabetes, [35][36][37][38][39][40][41][42][43][44][45][46] some results are still conflicting, and this is due mainly to the different methodologies adopted. For this reason, the mechanism responsible for alterations in vitamin A levels and the presence of diabetes has not been entirely elucidated.…”

Section: Vitamin A: Metabolism and Functionsmentioning

confidence: 99%

“…This way, the deficient state observed must be related to the vitamin's impaired transportation. The impairment of its metabolic availability is observed both in decompensated diabetes patients and streptozotocin (STZ) rats-diabetes induced 35,36,38 and Bio-Breed (BB) rats, 37 evidenced through decreased seric retinol levels and seric and hepatic RBP.…”

Section: Vitamin A: Metabolism and Functionsmentioning

confidence: 99%

“…In this case, due to metabolic alterations, the practice of supplementing vitamin A may increase its concentration in the liver, leading to a hepatic toxicity. 35,36 Moreover, VAD predisposes pregnant women to spontaneous abortion and higher severity in gestational intercurrences, besides being associated with infections, anemia, and the development of hypertensive pregnancy syndromes. 51 Knowing VA's relevant physiological roles and the factors influencing their concentrations, the need of monitoring this vitamin during gestation becomes clear, mainly if it is accompanied by diabetes mellitus, in order to prevent the emergence of other pathological complications for mother and infant.…”

Section: Vitamin A: Deficiency and Diabetes Mellitusmentioning

confidence: 99%

“…29 However, certain maternal factors may influence retinol concentrations in breast milk, among them the lactation stage; 30 breastfeeding process; 31 gestational age; 32 ; parity 33 ; VA in maternal diet; 34 zinc's nutritional state; 22 and pathologies as diabetes mellitus. [35][36][37][38][39] Vitamin A: rbP and diabetes mellitus Individuals with diabetes mellitus have been considered a group in risk of presenting marginal nutritional state or deficient in many related micronutrients and composites, such as vitamins A, E, C and carotenoids. [38][39][40] Accordingly, women with gestational diabetes have also been suggested as a group in risk of presenting reduced VA levels.…”

Section: Vitamin A: Metabolism and Functionsmentioning

confidence: 99%

See 2 more Smart Citations

Vitamina A e diabetes gestacional

Lira¹,

Dimenstein²

2010

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Expression of ß‐carotene 15,15′‐monooxygenase gene and retinol status in type 2 diabetic Goto‐kakizaki rats

Takitani¹,

Miyazaki²,

Takaya³

et al. 2008

BioFactors

View full text Add to dashboard Cite

The vitamin A status has been studied in type 2 diabetes and it is known that plasma retinol levels of patients with type 2 diabetes are elevated. However, the details of vitamin A metabolism in type 2 diabetes are unclear. beta-Carotene exhibits biological activity as provitamin A and beta-carotene 15,15'-monooxygenase (BCM) cleaves beta-carotene to form retinal. We studied BCM gene expression in type 2 diabetic Goto-Kakizaki (GK) rats. BCM gene expression was analyzed in the liver, intestine, and testis of 8- and 13-week-old GK rats and Wistar rats (control). The plasma and liver retinol levels were measured, and plasma retinol-binding protein (RBP) was detected. BCM gene expression in the liver, intestine and testis of GK rats was increased compared with that in controls. Plasma retinol levels and RBP levels were increased in GK rats, but hepatic retinol levels did not differ between GK rats and controls. BCM gene expression in the liver and intestine might affect retinol levels in type 2 diabetes. Conversion of beta-carotene to retinal might be accelerated in the presence of insulin resistance status, so that plasma retinol levels are increased in type 2 diabetes.

show abstract

Streptozotocin-induced diabetes in rats is associated with impaired metabolic availability of vitamin A (retinol)

Cited by 58 publications

References 24 publications

Retinol, α-tocopherol and carotenoids in diabetes

Retinol, α-tocopherol and carotenoids in diabetes

Vitamina A e diabetes gestacional

Expression of ß‐carotene 15,15′‐monooxygenase gene and retinol status in type 2 diabetic Goto‐kakizaki rats

Contact Info

Product

Resources

About