Streptozotocin-induced diabetes affects the development and maintenance of morphine reward in rats

Samandari, Razieh; Chizari, Atieh; Hassanpour, Rezvan; Mousavi, Zahra; Haghparast, Abbas

doi:10.1016/j.neulet.2013.03.024

Cited by 17 publications

(12 citation statements)

References 34 publications

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“…These data could also interpreted as an increase in tonic pain in STZ-treated mice at 7 days post-STZ. 33 Our data now indicate that stages of hypersensitivity, which develop at 5 to 7 weeks post-STZ, are marked by both tonic pain as well as hypersensitivity to heat and mechanical stimuli. Interestingly, electrophysiological recordings performed at 4 weeks post-STZ treatment in peripheral skin–nerve recordings have revealed an on-going discharge in diabetic, but not control, C-fibres as well as exaggerated sensitivity to nociceptive and non-nociceptive strengths of somatic stimuli.…”

Section: Discussionsupporting

confidence: 52%

“…32 In the context of diabetes, delivery of a soluble epoxide hydroxylase inhibitor has been reported to induce CPP at early stages in a model of diabetes. 32 Razieh Samandari 33 studied the impact of diabetes on morphine-induced CPP at 7 days post-STZ and concluded that the rewarding properties of morphine increased at 7 days post-STZ. These data could also interpreted as an increase in tonic pain in STZ-treated mice at 7 days post-STZ.…”

Section: Discussionmentioning

confidence: 99%

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Evoked hypoalgesia is accompanied by tonic pain and immune cell infiltration in the dorsal root ganglia at late stages of diabetic neuropathy in mice

et al. 2018

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Diabetic peripheral neuropathy is a major debilitating late complication of diabetes, which significantly reduces the quality of life in patients. Diabetic peripheral neuropathy is associated with a wide spectrum of sensory abnormalities, where in loss of sensation or hypoalgesia to applied external stimuli is paradoxically accompanied by debilitating tonic spontaneous pain. In numerous studies on animal models of diabetic peripheral neuropathy, behavioural measurements have been largely confined to analysis of evoked withdrawal to mechanical and thermal stimuli applied to dermatomes, whereas spontaneous, on-going pain has not been widely studied. In the Streptozotocin model of type 1 diabetes, we employed the Conditioned Place Preference test to assess tonic pain. Our results indicate that both phases, that is, early evoked hypersensitivity (i.e. 5–7 weeks post-Streptozotocin) as well as late stage hypoalgesia (i.e. 17–20 weeks post-Streptozotocin) are accompanied by significant tonic pain in mice with diabetic peripheral neuropathy. We also report on the temporal relation between on-going pain and neuropathological changes in the dorsal root ganglia of mice with diabetic peripheral neuropathy up to 6 months post-Streptozotocin. Neither early hypersensitivity nor late hypoalgesia were associated with markers of cellular stress in the dorsal root ganglia. Whereas significant neutrophil infiltration was observed in the dorsal root ganglia over both early and late stages post-Streptozotocin, T-cell infiltration in the dorsal root ganglia was prominent at late stages post-Streptozotocin. Thus, longitudinal analyses reveal that similar to patients with chronic diabetic peripheral neuropathy, mice show tonic pain despite sensory loss after several months in the Streptozotocin model, which is accompanied by neuroimmune interactions in the dorsal root ganglia.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Evoked hypoalgesia is accompanied by tonic pain and immune cell infiltration in the dorsal root ganglia at late stages of diabetic neuropathy in mice

et al. 2018

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“…It appears that decreasing insulin in DM (type I) can affect the brain reward system (Samandari et al, 2013). It has also been proven that insulin signalling regulates DA neurotransmission, affects the ability of psychostimulants in the DA system and facilitates their neurochemical and behavioural outcomes.…”

Section: Introductionmentioning

confidence: 99%

Effect of insulin deficiency on the rewarding properties of methamphetamine in streptozotocin-induced diabetic rats

Bayat

Haghparast

2015

Pharmacology Biochemistry and Behavior

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“…The latter study also found no differences in the magnitude of amphetamine-induced CPP in vehicle-versus STZ-treated rats (Sevak et al, 2008). STZ-treated rats display a larger magnitude of CPP produced by methamphetamine (Bayat & Haghparast, 2015;Kamei & Ohsawa, 1996) and morphine (Kamei, Ohsawa, & Suzuki, 1997;Samandari et al, 2013). Previous work has also shown that STZtreated rats display greater sensitivity to the behavioral effects (locomotor activity, catalepsy, and yawning) of dopamine D2/D3 receptor agonists (Sevak et al, 2007;Sevak, Koek, & France, 2005).…”

Section: Other Drugs Of Abusementioning

confidence: 75%

Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes

Cruz

Flores

Uribe

et al. 2019

Neuropsychopharmacol.

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Ibarra, Francisco Flores, and Israel Garcia. Many thanks for their countless help, encouragement, and laughs throughout this time in graduate school. I could not have asked for a better group of people to work with. Lovingly, I would like to thank my parents, Gerardo Cruz and Carmen Rios, and my siblings, Narlin Cruz and Jerry Cruz, for their endless love and support for my life goals. Many thanks to my best friends, Jorge Abraham Rodriguez and Adrian Macias for their constant encouragement. Lastly and lovingly, I would like to thank Claudia Jane Woloshchuk for her immense patience, support, commitment, and for always be there for me throughout this time. All of their continuous reinforcement is the spark for my enthusiasm.

show abstract

Streptozotocin-induced diabetes affects the development and maintenance of morphine reward in rats

Cited by 17 publications

References 34 publications

Evoked hypoalgesia is accompanied by tonic pain and immune cell infiltration in the dorsal root ganglia at late stages of diabetic neuropathy in mice

Evoked hypoalgesia is accompanied by tonic pain and immune cell infiltration in the dorsal root ganglia at late stages of diabetic neuropathy in mice

Effect of insulin deficiency on the rewarding properties of methamphetamine in streptozotocin-induced diabetic rats

Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes

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