Streptomycin functionalization on silver nanoparticles for improved antibacterial activity

Shruthi, T.S.; Meghana, M; Medha, M.U.; Sanjana, S.; Navya, P. N.; Daima, Hemant Kumar

doi:10.1016/j.matpr.2019.02.181

Cited by 24 publications

(21 citation statements)

References 17 publications

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“…The amount of antibiotics bound by LCLB56_AgNPs (1), sorption effectiveness at each incubation period (2) and binding rate constants for zero (3), pseudo-first (4) and -second (5) order kinetic models as well as Weber-Morris intra-particle diffusion model (6) were calculated as it was described by Buszewski et al [12], applying the following equations:…”

Section: Kinetics Study Of Antibiotics Sorption Onto Lclb56 Silver (Bmentioning

confidence: 99%

“…Many previous studies confirmed the increasing antibacterial efficiency of silver nanoparticles and antibiotics. Shruthi et al [2] showed that different types of silver nanoparticles after its functionalization with streptomycin had better antibacterial activity than non-functionalized nanoparticles against S. aureus and E. coli. In addition, Brown et al [7] demonstrated that chemically synthetized silver nanoparticles functionalized with ampicillin inhibit the growth of bacteria resistant to ampicillin more effectively.…”

Section: Determination Of Minimum Inhibitory Concentration and Flow Cmentioning

confidence: 99%

“…Nowadays, over 70% of bacterial infections are caused by strains resistant to at least one type of the most commonly used drugs [1]. The mechanism of microbial resistance is very complex, strain specific and can be influenced by many factors, such as growth conditions, life form or the metabolic state of the cells [2][3][4][5]. Therefore, the development of new substances with bactericidal properties is extremely important for health care [1,2,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism of microbial resistance is very complex, strain specific and can be influenced by many factors, such as growth conditions, life form or the metabolic state of the cells [2][3][4][5]. Therefore, the development of new substances with bactericidal properties is extremely important for health care [1,2,6,7]. Considerable interest is focused on the use of silver-based substances as an alternative to traditional drugs [1,2,[8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the development of new substances with bactericidal properties is extremely important for health care [1,2,6,7]. Considerable interest is focused on the use of silver-based substances as an alternative to traditional drugs [1,2,[8][9][10][11][12]. The antiseptic properties of silver have been known to mankind for centuries.…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Different Forms of Silver on Selected Pathogenic Bacteria

et al. 2020

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The application of silver nanoparticles as an antibacterial agent is becoming more common. Unfortunately, their effect on microorganisms is still not fully understood. Therefore, this paper attempts to investigate the influence of silver ions, biologically synthesized silver nanoparticles and nanoparticles functionalized with antibiotics on molecular bacteria profiles. The initial stage of research was aimed at the mechanism determination involved in antibiotics sorption onto nanoparticles’ surface. For this purpose, the kinetics study was performed. Next, the functionalized formulations were characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and a zeta potential study. The results reveal that functionalization is a complex process, but does not significantly affect the stability of biocolloids. Furthermore, the antimicrobial assays, in most cases, have shown no increases in antibacterial activity after nanoparticle functionalization, which suggests that the functionalization process does not always generate the improved antimicrobial effect. Finally, the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) technique was employed to characterize the changes in the molecular profile of bacteria treated with various antibacterial agents. The recorded spectra proved many differences in bacterial lipids and proteins profiles compared to untreated cells. In addition, the statistical analysis of recorded spectra revealed the strain-dependent nature of stress factors on the molecular profile of microorganisms.

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