Streptomyces thermoviolaceus SRC3 strain as a novel source of the antibiotic adjuvant streptazolin: A statistical approach toward the optimized production

Djinni, Ibtissem; Djoudi, Warda; Souagui, Samiha; Farida, Rabia; Rahmouni, Sihem; Mancini, Ines; Kecha, Mouloud

doi:10.1016/j.mimet.2018.04.008

Cited by 17 publications

(10 citation statements)

References 46 publications

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“…[91]. A series of polyether antibiotics including nigericin (40), epinigericin (41), abierixin (42), and the new grisorixin methyl ester (43) were isolated from the Streptomyces youssoufiensis SF10 strain collected from Chélia Mountain, in Khenchela (North-eastern Algeria) [105]. The online coupled HPLC-ESIMS analysis provided the full polyether profile, and the preparative HPLC technique in the reversed phase condition gave pure compounds, which were identified by extensive NMR and ESI-MS spectra in comparison with reported data.…”

Section: Antimicrobialsmentioning

confidence: 99%

“…Recently, Djinni et al [43] purified (+)-streptazolin (37), produced as a major compound in an appreciable amount from Streptomyces thermoviolaceus SRC3, a fresh-water sediment-derived strain. The structural characterization of streptazolin, including its absolute configuration previously defined by X-ray crystallographic analysis on a derivative, was established by comparison of NMR, MS, and optical activity.…”

Section: Antimicrobialsmentioning

confidence: 99%

“…This affects a great biodiversity, rich and diversified in actinobacteria, to which corresponds a wide chemodiversity of metabolites. A number of actinobacteria has been isolated from different ecosystems including Saharan plants [34,38,39], caves [40], waste water [41,42], river sediments [43], hypersaline areas [44][45][46][47][48][49][50][51], Saharan desert soil [22,52], and derived algae [53]. The most studied sampling sites for the isolation of actinobacteria are listed in Figure 1.…”

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Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules

et al. 2019

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Actinobacteria, in particular “rare actinobacteria” isolated from extreme ecosystems, remain the most inexhaustible source of novel antimicrobials, offering a chance to discover new bioactive metabolites. This is the first overview on actinobacteria isolated in Algeria since 2002 to date with the aim to present their potential in producing bioactive secondary metabolites. Twenty-nine new species and one novel genus have been isolated, mainly from the Saharan soil and palm groves, where 37.93% of the most abundant genera belong to Saccharothrix and Actinopolyspora. Several of these strains were found to produce antibiotics and antifungal metabolites, including 17 new molecules among the 50 structures reported, and some of these antibacterial metabolites have shown interesting antitumor activities. A series of approaches used to enhance the production of bioactive compounds is also presented as the manipulation of culture media by both classical methods and modeling designs through statistical strategies and the associations with diverse organisms and strains. Focusing on the Algerian natural sources of antimicrobial metabolites, this work is a representative example of the potential of a closely combined study on biology and chemistry of natural products.

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Section: Antimicrobialsmentioning

confidence: 99%

Section: Antimicrobialsmentioning

confidence: 99%

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confidence: 99%

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Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules

et al. 2019

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“…Recently, many attempts have been made to optimize them using statistical experiment designs such as Taguchi method (Mahalaxmi et al., 2009), factorial fractional design (FFD) (Fontes et al., 2012), central composite design (CCD) (Srinivasulu et al., 2006; Djinni et al., 2018) and Box-Bunken design (BBD) (Vijayabharathi et al., 2012; Kim et al., 2014). The process through statistical approach such as response surface methodology (RSM) is an approach resulting economic, efficient and accurate (Ahsan et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Modeling improved production of the chemotherapeutic polypeptide actinomycin D by a novel Streptomyces sp. strain from a Saharan soil

Djinni

Defant

Djoudi

et al. 2019

Heliyon

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The novel bioactive actinobacterial strain GSBNT10 obtained from a Saharan soil, was taxonomically characterized using a polyphasic approach. 16S rRNA gene sequence analysis supported the classification of the isolate within the genus Streptomyces indicating it as a novel species. The major metabolite responsible of the bioactivity was purified and structurally characterized as actinomycin D (act-D) by mass spectrometric and nuclear magnetic resonance analyses Plackett-Burman design (PBD) and response surface methodology (RSM) were applied in order to optimize the medium formulation for the production of this bioactive metabolite. By PBD experiments, NaNO 3 , K 2 HPO 4 and initial pH value were selected as significant variables affecting the metabolite production. Central Composite Design (CCD) showed that adjustment of the fermentative medium at pH 8.25, K 2 HPO 4 at 0.2 gL -1 and NaNO 3 at 3.76 gL -1 were the values suiting the production of act-D. Moreover, the results obtained by the statistical approach were confirmed by act-D detection using the HPLC equipped with a diode array detector and coupled online with electrospray-mass spectrometry (ESIMS) technique. act-D production was highly stimulated, obtaining a good yield (656.46 mgL -1 ) which corresponds to a 58.56% increase compared with the non-optimized conditions and data from LC-ESIMS technique efficiently confirmed the forecast from RSM.

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“…6,7 Streptazolin, mainly produced by members of the genus Streptomyces, presents antibiotic and antifungal activities. 8,9 Some synthesis research on the compound and its analogues has also been developed. [10][11][12] Recent research has proved that the compound can also increase bacterial killing and elaboration of immunostimulatory cytokines by macrophages.…”

Section: Introductionmentioning

confidence: 99%

The streptazolin- and obscurolide-type metabolites from soil-derivedStreptomyces albonigerYIM20533 and the mechanism of influence of γ-butyrolactone on the growth ofStreptomycesby their non-enzymatic reaction biosynthesis

Luo

Yang

et al. 2018

RSC Adv.

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Streptomyces thermoviolaceus SRC3 strain as a novel source of the antibiotic adjuvant streptazolin: A statistical approach toward the optimized production

Cited by 17 publications

References 46 publications

Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules

Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules

Modeling improved production of the chemotherapeutic polypeptide actinomycin D by a novel Streptomyces sp. strain from a Saharan soil

The streptazolin- and obscurolide-type metabolites from soil-derivedStreptomyces albonigerYIM20533 and the mechanism of influence of γ-butyrolactone on the growth ofStreptomycesby their non-enzymatic reaction biosynthesis

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