Streptomyces Species producing Oxytetracycline

The Serological Identification of Streptomycetes by Agar Gel Diffusion Techniques

“…A considerable degree of species specificity has been shown to exist. It is also possible that the technique may differentiate between the strains of some species (Cross, 1962). The antigens common to many species, which have caused difficulties in the application of conventional agglutination and precipitation tests, are also apparent.…”

Species and Strain Differentiation in Streptomyces by Gel Diffusion

“…'These results', they say, 'suggest that, since a pattern of lines reflects the structure of a number of proteins produced by the cells, the method may be of value in determining the true family re lationship among bacteria.' Cross (1962) isolated from soil two cultures of Streptomyces designated as A5279 and B7648, which produced oxytetracycline and bore close morphological and cultural resemblances to S. rimosus. When isolate A5279 was diffused simultaneously with S. rimosus against antiserum to A5279 they formed patterns of almost but not quite complete identity, which is interpreted to indicate a very close relationship but at the same time a strain difference, in close agreement with the differences in mycelium morphology.…”