Abstract:27Streptococcus pyogenes (GAS) is among the most diverse of all human pathogens, responsible 28 for a range of clinical manifestations, from mild superficial infections such as pharyngitis to 29 serious invasive infections such as necrotising fasciitis and sepsis. The drivers of these different 30 disease phenotypes are not known. The GAS cholesterol-dependent cytolysin, streptolysin O 31 (SLO), has well established cell and tissue destructive activity. We investigated the role of SLO 32 in determining disease… Show more
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