Streptokinase and splenic rupture

Wiener, Roy S.; Ong, Ling S.

doi:10.1016/0002-9343(89)90281-7

Cited by 15 publications

(3 citation statements)

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“…Major bleeding like Intracerebral Hemorrhage is usually seen in <1% of cases, and after 70 years of age the risk increases to 1.67% 14, 15. Hemorrhage can also occur into spleen, mediastinum, liver, intraspinally, tongue, and rectum 16, 17, 18, 19, 20. There has been only one case report in literature till now describing spontaneous psoas hematoma post-STK infusion 21 …”

Section: Discussionmentioning

confidence: 99%

Spontaneous psoas hematoma in a case of acute myocardial infarction following streptokinase infusion

Vijay

Avanthi

et al. 2016

Indian Heart Journal

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Section: Discussionmentioning

confidence: 99%

Spontaneous psoas hematoma in a case of acute myocardial infarction following streptokinase infusion

Vijay

Avanthi

et al. 2016

Indian Heart Journal

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“…A few cases in which spleen rupture followed the streptokinase therapy have been reported ( 16 - 19 ). In one of these cases, thrombolytic therapy was used for deep venous thrombosis ( 16 ), while in other cases it was used for acute myocardial infarction ( 17 - 19 ). In a case described by Cheung and colleagues, 3 hours after administration of the t-PA for acute myocardial infarction, shock and acute abdomen developed due to spleen rupture ( 20 ).…”

Section: Review Of Literaturementioning

confidence: 99%

Spontaneous Splenic Rupture Following Intravenous Thrombolysis with Alteplase Applied as Stroke Therapy - Case Report and Review of Literature

Aleksić-Shihabi

Jadrijević

Milekic

et al. 2016

Med Arh

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Introduction:Stroke is a medical emergency in neurology, and is one of the leading causes of death nowadays. At a recent time, a therapeutic method used in adequate conditions is thrombolysis, a treatment of an emerging clot in the brain vascular system by alteplase. The application of alteplase also has a high risk of life threatening conditions.Case report:This is a brief report of a case with thrombolysis complication which manifested as a spleen rupture.

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“…13 The misdiagnoses of myocardial infarction or inadvertent administration of thrombolytic agents, as in this patient, can lead to significant complications. '4"15 Analysis of the TIMI study group revealed misdiagnoses of myocardial infarction in 20 (1.4%) of 1387 enrolled patients.14 However, there were no adverse outcomes. Rigid criteria kept at-risk patients for further evaluation and led to a low misdiagnosis rate.…”

Section: Hospital Coursementioning

confidence: 99%

A 63-year-old man who developed severe abdominal pain after thrombolytic therapy.

Li¹,

McDonald²,

Chen³

1993

Circulation

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Case History (Glenn McDonald, MD)A63-year-old white man with no significant past medical history presented to an outlying hospital with a chief complaint of substernal chest discomfort. The patient was in his usual state of health until~1 to 2 months before admission, when he noticed generalized increased fatigue with exertion. One day before admission at~5:30 PM, he developed a nonradiating substernal chest discomfort that was described as a severe pressure sensation with associated nausea, diaphoresis, and dizziness. He denied any vomiting or dyspnea. This discomfort persisted for %3 hours and was markedly decreased after taking two sublingual nitroglycerin tablets. He subsequently had similar intermittent episodes of substernal chest discomfort occurring every 45 to 60 minutes and lasting 10 to 15 minutes. These episodes were associated with diaphoresis but would spontaneously resolve. At 2:30 AM, he then had an episode of severe chest pain with associated nausea and diaphoresis that lasted for~30 minutes and spontaneously resolved. He continued to have transient episodic chest pressure lasting :10 to 15 minutes, which would spontaneously resolve throughout the night.The morning of admission he called his physician and went to an outlying hospital. He specifically denied any history of orthopnea, paroxysmal nocturnal dyspnea, pedal edema, increased abdominal girth, fever, chills, cough, nausea, vomiting, diarrhea, melena, abdominal pain, or dysuria. He also denied any prior history of chest discomfort, bleeding disorders, headaches, visual changes, trauma, or preexisting illness. He had been told in the past that his cholesterol and triglycerides were elevated, but he denied any prior history of diabetes mellitus, hypertension, tobacco use, or family history of coronary artery disease. He has no drug allergies and was on no medication before admission.The patient's initial ECG was significant for nonspecific ST changes, and he was then admitted to the cardiac care unit. He was placed on continuous infusion of heparin and nitroglycerin, aspirin, and a calcium channel blocker. The patient was rendered pain free. Serial cardiac enzymes were not elevated, and his ECG A 63-year-old man who developed severe abdominal pain after thrombolytic therapy.

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Streptokinase and splenic rupture

Cited by 15 publications

References 1 publication

Spontaneous psoas hematoma in a case of acute myocardial infarction following streptokinase infusion

Spontaneous psoas hematoma in a case of acute myocardial infarction following streptokinase infusion

Spontaneous Splenic Rupture Following Intravenous Thrombolysis with Alteplase Applied as Stroke Therapy - Case Report and Review of Literature

A 63-year-old man who developed severe abdominal pain after thrombolytic therapy.

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