Streptococcus suis meningitis can require a prolonged treatment course

Dejace, Jean; Bagley, Patrick; Wood, Emily

doi:10.1016/j.ijid.2017.09.011

Cited by 15 publications

(14 citation statements)

References 9 publications

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“…We did not perform the detection because erythromycin and tetracycline was not the preferred drug for treating S.suis infection. According to the previous literature [19], a prolonged treatment course and close monitoring of patients upon completion of therapy for signs and symptoms of recrudescent disease were suggested and if symptoms recur, an additional treatment course based on clinical response will be considered. Our results enhanced the understanding of the distribution and evolution of the S. suis and their ability to cause life-threatening infections in humans.…”

Section: Discussionmentioning

confidence: 99%

Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type

et al. 2020

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Background: Streptococcus suis is a zoonotic pathogen that causes serious systemic infections in pigs and occupation-related infections in humans who contact with pigs or pork products. In China, it has caused two outbreaks of human infection and surveillance for S.suis has been ongoing since last time. Case presentation: Two cases of meningitis and sepsis caused by S. suis were reported in this study. Both patients work in relation to the pork trade, a risk factor for S. suis infection. The outcome was favorable after a prolonged ceftriaxone therapy but one patient was left with mild hearing loss. Two isolates were identified as sequencing type (ST) 7, S. suis serotype 2 (SS2), which is one the most prevalent and cause two outbreaks in China. Whole-genome sequencing (WGS) revealed that a high degree identity was noted in the genome organizations and sequences between two sporadic ST7 SS2 isolates in this study and representative epidemic virulent isolates. Major differences among them are two sporadic ST7 SS2 isolates lacked a virulence factor called agglutinin receptor and an 89 K pathogenicity island (PAI), which plays important role in the pathogenesis of streptococcal toxic shock syndrome (STSS). A summary about STs of human infection with S. suis in China was completed. The result showed ST1 and ST7 were still the major STs and several novel STs were successfully discovered in different provinces. Conclusions: Our results enhanced the understanding of the ability to cause life-threatening infections in humans and the distribution and evolution of the S. suis in China.

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Section: Discussionmentioning

confidence: 99%

Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type

et al. 2020

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“…Streptococcus suis type 2 is a zoonotic pathogen that can cause meningitis, bacteremia, septicemia, endocarditis, and arthritis in pigs and humans. Meningitis is the most serious symptom of S. suis 2 infection and often shows clinical symptoms including vertigo, ataxia, headaches, neck stiffness, fevers, nausea, deafness and so on (Madsen et al, 2002 ; Mai et al, 2008 ; van Samkar et al, 2015 ; Dejace et al, 2017 ; Sena et al, 2017 ), and histopathological features including the presence of fibrin, edema and cell infiltration in the meninges and choroid plexus. As a result, this pathogen poses a great threat not only to the swine industry but also to human health.…”

Section: Introductionmentioning

confidence: 99%

Differential Protein Profiling of Cerebrospinal Fluid in Piglets with Severe Meningoencephalitis Caused by Streptococcus suis Type 2 Compared to Controls

Liu

Guo

et al. 2018

Front. Cell. Infect. Microbiol.

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Streptococcus suis serotype 2 (SS2) is a zoonotic pathogen that can cause meningitis both in pigs and in human beings. However, the pathogenesis of central nervous system (CNS) infection caused by SS2 have not yet been elucidated. To find the key molecules in cerebrospinal fluid (CSF) needed for the pathogenesis, a SS2 meningoencephalitic pig model and a SS2 non-meningoencephalitic pig model were established in this study. CSF was collected from infected piglets, and protein profiling was performed with label-free proteomics technology. A total of 813 differential proteins, including 52 up-regulated proteins and 761 down-regulated proteins, were found in the CSF of meningoencephalitic pigs compared with both non-meningoencephalitic pigs and healthy pigs. These 813 differential proteins were clustered into three main categories, namely, cellular component, biological process, and molecular function by gene ontology (GO) analysis. The most enriched subclasses of differential proteins in each category were exosome (44.3%), energy pathway (25.0%) and catalytic activity (11.3%), respectively. The most enriched subclasses of upregulated proteins were extracellular (62.1%), protein metabolism (34.5%) and cysteine-type peptidase activity (6.9%), and of downregulated proteins were exosomes (45.0%), energy pathway (24.0%) and catalytic activity (9.4%). Then, the differential proteins were further investigated by using the KEGG database and were found to participate in 16 KEGGs. The most enriched KEGG was citrate cycle (56.6%), and some of these differential proteins are associated with brain diseases such as Huntington's disease (18.6%), Parkinson's disease (23.8%) and Alzheimer's disease (17.6%). Sixteen of the 813 differential proteins, chosen randomly as examples, were further confirmed by enzyme-linked immunosorbent assay (ELISA) to support the proteomic data. To our knowledge, this is the first study to analyze the differential protein profiling of CSF between SS2 meningoencephalitic piglets and non-meningoencephalitic piglets by employing proteomic technology. The discovery and bioinformatics analysis of these differential proteins provides reference data not only for research on pathogenesis of SS2 CNS infection but also for diagnosis and drug therapy research.

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“…Meningitis and septicemia related to S. suis infection were first described in 1968 in Denmark [ 8 ]. Clinical presentation of S. suis infection is as follows: meningitis, pneumonia, arthritis, endophthalmitis, endocarditis, spontaneous bacterial peritonitis, skin lesions, bacteremia, and septic shock [ 3 , 9 ]. Partial or complete deafness is an important complication of S. suis meningitis.…”

Section: Discussionmentioning

confidence: 99%

“…S. suis is a pig pathogen and it is rarely identified in humans. There is emerging evidence of S. suis infections such as meningitis, peritonitis, and septic shock in especially immunodeficient patients [ 3 ]. In our center we reported a rare case of A. xylosoxidans relapsing peritonitis and a case of S. suis peritonitis.…”

Section: Introductionmentioning

confidence: 99%

Achromobacter xylosoxidans Relapsing Peritonitis and Streptococcus suis Peritonitis in Peritoneal Dialysis Patients: A Report of Two Cases

Donderski

Grajewska

Mikucka

et al. 2018

Case Reports in Nephrology

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Peritonitis is considered to be the most common complication of peritoneal dialysis (PD). It is usually caused by Gram positive Staphylococcus epidermidis. Achromobacter xylosoxidans (A. xylosoxidans) and Streptococcus suis (S. suis) are rare pathogens, but there is emerging evidence that they may be also responsible for PD related peritonitis. We described 2 cases of rare peritonitis treated in our center. In our opinion this is the first described case of PD related peritonitis caused by Streptococcus suis.

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Streptococcus suis meningitis can require a prolonged treatment course

Cited by 15 publications

References 9 publications

Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type

Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type

Differential Protein Profiling of Cerebrospinal Fluid in Piglets with Severe Meningoencephalitis Caused by Streptococcus suis Type 2 Compared to Controls

Achromobacter xylosoxidans Relapsing Peritonitis and Streptococcus suis Peritonitis in Peritoneal Dialysis Patients: A Report of Two Cases

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