Streptococcus Bovis Endocarditis and Colonic Cancer

Noble, C.J.; Uttley, AnneH.C.; Falk, R. H.; Richardson, Peter J.

doi:10.1016/s0140-6736(78)90874-7

Cited by 17 publications

(11 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They demonstrate a positive association of antibody responses to SGG proteins with CRC risk in pre-diagnostic samples, implicating SGG serology as a new marker for risk of developing CRC. caused by bacteria belonging to the S. bovis complex, [5][6][7] and later more specifically by the subspecies SGG, 8 co-occurred with the presence of colorectal adenoma. A systematic review of CRC case series by Boleij et al in 2011 showed that 60% of S. bovis-infected individuals in the reviewed studies had a concomitant colorectal adenoma/carcinoma and that SGGinfection was specifically responsible for this association compared to other S. bovis subtypes.…”

Section: Introductionmentioning

confidence: 97%

“…2 Changes in the local intestinal tissue can compromise the colonic barrier integrity resulting in a "leaky gut." caused by bacteria belonging to the S. bovis complex, [5][6][7] and later more specifically by the subspecies SGG, 8 co-occurred with the presence of colorectal adenoma. 4 An interesting candidate in this respect might be the intestinal commensal Streptococcus gallolyticus subspecies gallolyticus (SGG), formerly known as Streptococcus bovis biotype I.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer

Butt

Jenab

Willhauck‐Fleckenstein

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre-diagnostically. We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC risk in a case-control study nested within a prospective cohort. Pre-diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04-1.77). Positivity for two or more proteins of a previously identified SGG 6-marker panel with greater CRC-specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44-3.27). In this prospective nested case-control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.

show abstract

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer

Butt

Jenab

Willhauck‐Fleckenstein

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…This report was rapidly followed by similar observations by others which confirmed the findings of Klein and co-workers. (317)(318)(319)(320)(321)(322)(323) It now seems clear that any patient with Str. bovis endocarditis or bacteremia should have a thorough investigation for cancer, particularly of the gastrointestinal tract.…”

Section: Streptococcus Bovismentioning

confidence: 99%

Infective Endocarditis and Other Intravascular Infections

Freedman¹

1982

View full text Add to dashboard Cite

show abstract

“…The bacterial species Streptococcus bovis (S. bovis) has already been described in the 1970's to be connected to colorectal neoplasms: Infective endocarditis induced by this bacterium co-occurred in several reports with the presence of intestinal adenoma. [5][6][7] In 1989, it was postulated for the first time that especially one S. bovis subspecies (biotype I, later renamed to SGG), was the inducer of adenoma-associated infective streptococcal endocarditis. 8 Since then different case reports and case series replicated the finding of CRC or its precursors present in SGG-induced bacteremia/infective endocarditis patients at a higher rate compared to bacteremia/infective endocarditis induced by other bacteria.…”

mentioning

confidence: 99%

Serology of Streptococcus gallolyticus subspecies gallolyticus and its association with colorectal cancer and precursors

Butt

Werner

Willhauck‐Fleckenstein

et al. 2017

Intl Journal of Cancer

View full text Add to dashboard Cite

Streptococcus gallolyticus subspecies gallolyticus (SGG) is potentially associated with colorectal cancer (CRC) and its precursors. A previous case-control study measured antibody responses to SGG pilus proteins Gallo2178 and Gallo2179 and identified significant associations with a small fraction of CRC cases. We aimed at replicating and expanding these findings in an independent study including additional SGG antigens and explored the association with precancerous lesions. We applied multiplex serology to measure antibodies to eleven SGG proteins in serum samples of a screening colonoscopy trial (BliTz study) including participants diagnosed with either non-advanced adenoma (NAA, n = 30), advanced adenoma (AA, n = 100), CRC (n = 50) or controls (n = 228). In addition, we analyzed CRC samples (n = 318) from patients recruited in a clinical setting (DACHSplus study). The association of antibody responses to SGG pilus proteins Gallo2178 and Gallo2179 with CRC was replicated with 4% positive DACHSplus cases compared to 0% positive BliTz controls. Positivity to two or more proteins of a newly defined panel of six SGG markers was significantly associated with CRC in the DACHSplus study (OR: 1.81, 95% CI: 1.07-3.06). Odds for CRC, AA and NAA in the BliTz study were also increased with antibody responses to SGG, and the association was significant for NAA (OR: 2.98, 95% CI: 1.18-7.57). Antibody responses to SGG are associated with CRC and its precursors. The newly identified SGG six-marker panel and associations found with precancerous lesions should be further explored.

show abstract

Streptococcus Bovis Endocarditis and Colonic Cancer

Cited by 17 publications

References 2 publications

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer

Infective Endocarditis and Other Intravascular Infections

Serology of Streptococcus gallolyticus subspecies gallolyticus and its association with colorectal cancer and precursors

Contact Info

Product

Resources

About