Streptococcus acidominimus causing invasive disease in humans: a case series

Abstract

IntroductionStreptococcus acidominimus is a member of the viridans group streptococci and is rarely pathogenic in humans, making it difficult to assess its epidemiologic and clinical significance.Case presentationWe report the cases of five Han Chinese patients with invasive diseases caused by S. acidominimus over a one-year time frame. Three of the patients developed continuous fever after surgery, consisting of a successful elective laparoscopic cholecystectomy (case 1), a laparoscopic esophageal resection and gastroesophageal anastomosis (case 2), and a liver transplant in a patient with liver cancer (case 3). For these three patients, cultures of the purulent drainage material grew S. acidominimus. Case 4 concerns a 52-year-old man who developed sepsis 48 hours after hospitalization for hepatitis, liver cirrhosis and hepatitis-related glomerulonephritis. Case 5 concerns a 55-year-old woman receiving regular hemodialysis who had low-grade fever for one month. For these two patients, blood cultures grew S. acidominimus. An antimicrobial susceptibility test revealed that S. acidominimus was resistant to clindamycin and, to some degree, beta-lactam or macrolides. The S. acidominimus from the patient on hemodialysis was resistant to multiple antibiotics.ConclusionS. acidominimus is an ever-increasing cause of disease, especially in patients who are critically ill. It is showing increased resistance to antimicrobial agents, so in patients with viridans group streptococci infections, it is necessary to identify the species to improve the clinical management of S. acidominimus.

Relationship between the microbiota in different sections of the gastrointestinal tract, and the body weight of broiler chickens

“…S. mutans group bacteria (Loesche 1986 ; Simon-Soro and Mira 2015 ) and S. mitis group bacteria (Mitchell 2011 ; Catto et al 1987 ) are known pathogens of the buccal cavity. In humans, S. acidominius is a known pathogen that causes invasive diseases (Wu et al 2014 ) such as pneumonia (Baker and Carlson 2008 ; Akaike et al 1988 ), meningitis (Finkelstein et al 2003 ) and brain abscess (Cone et al 2007 ). Our data is consistent with the hypothesis that pathogenic Streptococcus might affect BW yet a more detailed analysis of the Streptococcus community is needed.…”

Pyogenic Ventriculitis and Meningitis Caused by Streptococcus Acidominimus in Humans: A Case Report

“…Although recognition of infections with S. acidominimus is increasing [ 2 ], this article is the first case report of PV and meningitis caused by S. acidominimus in North America, and occurred more than a quarter century after this infection was first reported in Japan, as shown in Table 1 . Fortunately, despite reports of increasing resistance to antibiotics [ 2 ], S. acidominimus remains sensitive to ceftriaxone and other betalactam antibiotics.…”

“…Streptococcus acidominimus , which belongs to the viridans streptococci group, is commonly found in food and bovine udders and is rarely considered pathogenic in humans [ 1 ]. However, Wu et al [ 2 ] summarized previous case reports of highly invasive diseases, including meningitis, brain abscess, Gradenigo syndrome/otitis media, endocarditis, empyema, acute cholecystitis, sepsis, and massive ascites, caused by S. acidominimus in humans. In addition, a previous case report of meningitis due to S. acidominimus was reported by Akaike et al in Japan.…”

Unusual cause of infective endocarditis in an elderly patient with a rare condition

“…It is a normal inhabitant of bovine skin, vagina and raw milk. Limited cases causing infections of wounds, cysts, external abscess, pericarditis, pneumonia, meningitis and urethral infection have been reported in humans 3 4. To date, only two cases of S. acidominimus endocarditis have been reported in the literature,2 3 thus the clinical and epidemiological significance of this pathogen remain uncertain.…”