Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes

Abstract

Background Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular epidemiology analysis has suggested that the frequency of emm3 GAS has been recently increasing.Case presentationA 14-year-old patient was diagnosed with streptococcal toxic shock syndrome and severe pneumonia, impaired renal function, and rhabdomyolysis. GAS was isolated from a culture of endotracheal aspirates and designated as KS030. Comparative genome analysis suggested that KS030 is classified as emm3 (emm-type) and ST15 (multilocus sequencing typing [MLST]), which is similar to iGAS isolates identified in the UK (2013) and Switzerland (2015).ConclusionsWe conclude that the global dissemination of emm3/ST15 GAS strain has the potential to cause invasive disease.Electronic supplementary materialThe online version of this article (10.1186/s12879-017-2870-2) contains supplementary material, which is available to authorized users.

Antimicrobial activity of the extracts of Albizia masikororum R.Vig., a Fabaceae from Madagascar

“…LME and SME displayed an excellent effect against Streptococcus pneumoniae and Streptococcus pyogenes. Those two bacteria, because of their high prevalence in infectious diseases and their resistance to various antibiotics, have become a serious clinical and health problem in many countries (Nuermberger and Bishai, 2004;Ardanuy et al, 2014;Lu et al, 2017;Sekizuka et al, 2017;Zhao et al, 2017).…”

Pemanfaatan Buah Belimbing Wuluh (Averrhoa bilimbi L.) Sebagai Alternatif Penanganan Toxic Shock Syndrome

“…Toxic Shock Syndrome (TSS) merupakan penyakit akut yang mengancam jiwa yang dimediasi oleh racun, biasanya dipicu oleh infeksi Staphylococcus aureus atau grup A Streptococcus (GAS), yang juga disebut Streptococcus pyogenes [3]. Streptococcus pyogenes (grup A Streptococcus [GAS]) merupakan patogen yang dapat menyebabkan manifestasi klinik dengan spektrum luas pada manusia [10].…”

The Bacterial Markers of Identification of Invasive CovR/CovS-Inactivated Group A Streptococcus

“…GAS isolates are classified by the widely used single-locus sequence emm- typing system. More than 250 different emm types have been identified, with emm 1- and emm 3-GAS frequently associated with severe clinical manifestations ( 9 – 11 ). Furthermore, spontaneous inactivating mutations in genes encoding the CovR/CovS ( c ontrol o f v irulence) two-component regulatory system are significantly related to necrotizing fasciitis and toxic shock syndrome ( 12 – 14 ).…”