Streptococcal toxic shock syndrome caused by β-hemolytic streptococci: Clinical features and cytokine and chemokine analyses of 15 cases

Yoshizawa, Sadako; Matsumoto, Takayuki; Ikebe, Tadayoshi; Ichibayashi, Ryo; Fukui, Yusuke; Satoh, Takahiro; Tsubota, Takaya; Honda, Masashi; Ishii, Yoshikazu; Tateda, Kazuhiro; Ato, Manabu

doi:10.1016/j.jiac.2019.01.006

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…Although IL-6 production is known to occur following severe invasive GAS infection in humans (Wang et al, 2008;Yoshizawa et al, 2019), the exact roles of IL-6 during GAS infection remain controversial in both mice and human studies (De Benedetti et al, 2012;Klein et al, 2007;Norrby-Teglund et al, 1995;van de Sande and van Slobbe-Bijlsma, 2012;Yoshida et al, 2012). We show here that gIMC-derived IL-6 is vital for directing Mincle expression for prompt IFN-g production, which subsequently contributes to the clearance of GAS.…”

Section: Discussionmentioning

confidence: 57%

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Matsumoto

Ikebe

Arikawa³

et al. 2019

Cell Reports

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Section: Discussionmentioning

confidence: 57%

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Matsumoto

Ikebe

Arikawa³

et al. 2019

Cell Reports

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“…causes the degradation of muscle tissue simultaneously with the propagation of Vibrio cells in host tissues and that catabolic metabolites seem to leak into the blood from skeletal muscle. In addition, previous studies reported that the blood creatine phosphokinase level was increased in necrotizing fasciitis by group A beta-hemolytic streptococci ( 31 , 32 ). Therefore, the measurement of metabolites associated with muscle catabolism is expected to be useful for estimating the seriousness of wound infections, including those caused by Vibrio spp., in blood clinical biochemistry tests.…”

Section: Discussionmentioning

confidence: 93%

Characteristic Metabolic Changes in Skeletal Muscle Due to Vibrio vulnificus Infection in a Wound Infection Model

et al. 2023

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“…The best-described superantigen is exotoxin A, which, through the stimulation of a large proportion of circulating T cells, creates a massive cytokine release leading to capillary leak and profound hypotension. This process initiates an inflammatory cascade responsible for STSS [8].…”

Section: Discussionmentioning

confidence: 99%

A Critical Case of Streptococcal Toxic Shock Syndrome: A Case Report

Nunez Cuello,

Bhattarai,

Shin

2024

Cureus

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A 41-year-old woman with a history of asthma presented to the emergency department with complaints of progressive malaise, dyspnea, vomiting, and diarrhea for a week. Upon presentation, the patient was hemodynamically unstable and exhibited severe respiratory distress. A chest computed tomography revealed consolidation of the left upper lobe with confluence in the left perihilar region and a left pleural effusion. The patient was admitted to the intensive care unit for further management of respiratory failure, and a chest tube was placed on the left side. Despite the absence of bacteremia, the diagnosis of Streptococcal toxic shock syndrome was confirmed through a pleural fluid culture positive for Streptococcus pyogenes and evidence of multiorgan failure. Her treatment included vasopressors, broad-spectrum antibiotics, and intravenous immunoglobulin. For renal failure, the patient required continuous renal replacement therapy. Despite all these interventions, the patient continued to decline, and left-sided videoassisted thoracoscopic surgery was pursued with subsequent improvement of her condition. The incidence of invasive Group A streptococcal disease is significant, with notable mortality and morbidity among affected patients. The rapid deterioration is thought to be secondary to the highly virulent nature of the pathogen and the production of superantigens. The rapid institution of adequate antibiotic coverage with beta-lactams and clindamycin has been shown to decrease the mortality rate. Intravenous immunoglobulin has also been included with a promising positive effect.

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Streptococcal toxic shock syndrome caused by β-hemolytic streptococci: Clinical features and cytokine and chemokine analyses of 15 cases

Cited by 7 publications

References 39 publications

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Characteristic Metabolic Changes in Skeletal Muscle Due to Vibrio vulnificus Infection in a Wound Infection Model

A Critical Case of Streptococcal Toxic Shock Syndrome: A Case Report

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