Streptococcal Pharyngitis

Randolph, Martin F.; Redys, John J.; Cope, John B.; Morris, Kathleen E.

doi:10.1177/000992287501400201

Cited by 12 publications

(1 citation statement)

References 5 publications

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“…Several studies have demonstrated that clindamycin and its parent compound, lincomycin, are successful in the treatment of recurrent streptococcal illness or the strep tococcal carrier state [14][15][16], possibly due to their effectiveness against GABHS and bcta-lactamase-producing aerobic and an aerobic organisms in the tonsillar tissue. Further studies of the protective effects of other beta-lactamase-producing Bacteroides strains present in tonsillar tissue will clarify also their influence on the response to peni cillin.…”

Section: Discussionmentioning

confidence: 99%

In vitro Protection of Group A Beta-Hemolytic Streptococci from Penicillin and Cephalothin by <i>Bacteroides fragilis</i>

Brook

Yokum

1983

Chemotherapy

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Beta-lactamase produced by Bacteroides fragilis could protect from antibiotics group A beta-hemolytic streptococci (GABHS), penicillin-susceptible pathogens frequently isolated from acute tonsillitis in children. To test this hypothesis we determined the minimal bactericidal concentration (MBC) to penicillin and cephalothin of GABHS alone and in mixed culture with eleven beta-lactamase-producing strains of B. fragilis. B. fragilis strains with MBC values ≤ 32 μg/mlto penicillin and ≤64 μg/ml to cephalothin did not provide any protection for GABHS. However, strains with MBC ≥ 128 μg/ml to penicillin and ≥ 256 μg/ml to cephalothin provided protection by increasing the MBC of GABHS at least 8,534 times for penicillin and 2,048 times for cephalothin. This phenomenon was most marked in 5% CO₂. B. fragilis provided no protection against clindamycin. These results may explain the inability of penicillin therapy to completely eradicate GABHS from cases of recurrently infected tonsils.

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Section: Discussionmentioning

confidence: 99%