Streptocarbazoles A and B, Two Novel Indolocarbazoles from the Marine-Derived Actinomycete Strain Streptomyces sp. FMA

Abstract

Streptocarbazoles A (1) and B (2), two novel indolocarbazoles featuring unprecedented cyclic N-glycosidic linkages between 1,3-carbon atoms of the glycosyl moiety and two indole nitrogen atoms of the indolocarbazole core, were isolated from the marine-derived actinomycetes strain Streptomyces sp. FMA. Their structures were established by spectroscopic methods, CD spectra, and ECD quantum mechanical calculations. Compound 1 was cytotoxic on HL-60 and A-549 cell lines and could arrest the cell cycle of Hela cells at the G(2)/M phase.

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit

“…5). 85 Two new indolo[3,2-a]carbazoles 184 and 185 were isolated from a deep-water collection of a sponge of the genus Asteropus. Compound 185 showed a minimum inhibitory concentration of 25 mg mL À1 against Candida albicans and 50 mg mL À1 against MRSA (Fig.…”

Natural Products from Mangrove Actinomycetes

“…Other examples are the xiamycins, which are indolosesquiterpenes compounds, isolated from prokaryotes for the first time [23]. Novel indolocarbazoles identified from a mangrove streptomycete present unprecedented cyclic N -glycosidic linkages between 1,3-carbon atoms of the glycosyl moiety and two indole nitrogen atoms of the indolocarbazole core with anticancer activity [24]. The mangrove environment is a virtually untapped source of novel and diverse natural products and needs much more attention.…”

Ocean Dwelling Actinobacteria as Source of Antitumor Compounds

“…strain FMA was isolated from a mangrove soil collected in Sanya, Hainan Province of China. The ethyl acetate extracts contained two novel indolocarbazoles, streptocarbazoles A and B, which exhibited potent cytotoxicity against HL-60 and A549 cell lines (Fu et al 2012). Actinomadura sp.…”