Streptobacillus Moniliformis Isolated From Blood in Four Cases of Haverhill Fever

Shanson, D.C.; Midgley, J.; Gazzard, Brian; Dixey, J.; Gibson, G.L.; Stevenson, James; Finch, Roger; Cheesbrough, J.

doi:10.1016/s0140-6736(83)90072-7

Cited by 44 publications

(21 citation statements)

References 4 publications

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“…After 5 days of growth, some colonies may demonstrate the "fried-egg" appearance seen with the L form. Importantly, the 0.05% sodium polyanethol sulfonate ("Liquoid") that is added to most commercial aerobic blood culture bottles as an anticoagulant inhibits the growth of S. moniliformis at a concentration as low as 0.0125% (74). However, Trypticase soy agar or broth, resin bead culture systems, and anaerobic culture bottles may demonstrate growth because sodium polyanethol sulfonate typically is not added (46,68,75).…”

Section: Growth Characteristicsmentioning

confidence: 99%

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Rat Bite Fever andStreptobacillus moniliformis

2007

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SUMMARY Rat bite fever, caused by Streptobacillus moniliformis, is a systemic illness classically characterized by fever, rigors, and polyarthralgias. If left untreated, it carries a mortality rate of 10%. Unfortunately, its nonspecific initial presentation combined with difficulties in culturing its causative organism produces a significant risk of delay or failure in diagnosis. The increasing popularity of rats and other rodents as pets, together with the risk of invasive or fatal disease, demands increased attention to rat bite fever as a potential diagnosis. The clinical and biological features of rat bite fever and Streptobacillus moniliformis are reviewed, providing some distinguishing features to assist the clinician and microbiologist in diagnosis.

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Section: Growth Characteristicsmentioning

confidence: 99%

“…(59). In a description of four cases from this outbreak (74), the clinical features were described as abrupt onset of fever with headache, peripheral erythematous rash, polyarthralgias, and subsequent sore throat. Initial diagnoses included viral illness (especially coxsackievirus), meningococcal septicemia, and erythema multiforme.…”

Section: Haverhill Fevermentioning

confidence: 99%

Rat Bite Fever andStreptobacillus moniliformis

2007

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“…moniliforrnis are relatively rare but in 1983 there was an outbreak of Haverhill fever affecting more than 130 pupils at a school in Chelmsford (Shanson et al, 1983) where the organism was isolated from the blood of just four patients. The organism also causes an arthritic disease in turkeys and is highly pathogenic for mice and various small laboratory animals (Hopkinson and Lloyd, 1981 ;Savage, 1984).…”

Section: Introductionmentioning

confidence: 99%

Numerical analysis of electrophoretic protein patterns of Streptobacillus moniliformis strains from human, murine and avian infections

Costas

Owen

1987

Journal of Medical Microbiology

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Summary. A total of 3 1 cultures representing 22 different strains of Streptobacillus rnoniliformis has been characterised by unidimensional SDS-PAGE of cell proteins. The isolates were from sporadic and outbreak cases of human infection in the USA, UK and France, as well as mouse, turkey and rat isolates from various countries. The protein patterns, which contained 40-50 discrete bands, were highly reproducible and were used as the basis for a numerical analysis. Three clusters were obtained at the 86% similarity (S) level and these were further divided to give a total of seven clusters at the 90% S level. S. moniliformis strains, irrespective of the original host or geographical location of isolation, had a characteristic protein profile that enabled them to be easily distinguished from allied unclassifiable organisms. The analysis showed that Haverhill fever strains can be clearly distinguished from rat-bite fever strains. Protein-band differences amongst the latter strains corresponded with different geographical locations. We conclude that high resolution PAGE combined with computerised analysis of protein profiles provides the basis for typing clinical isolates of S . rnoniliformis. Seven PAGE types were identified and reference strains for each have been designated as a basis for future studies.

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“…Humans get this infection from the bite of infected rodents or ingestion of contaminated food or water (11). RBF is characterized by relapsing fever, arthralgia, and rash and causes severe metastatic infections (6).…”

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confidence: 99%

“…However, this is difficult in routine practice, because S. moniliformis is a fastidious gram-negative bacillus that needs special media and environments for isolation (6). Sodium polyanethol sulfonate as an anticoagulant in commercial blood culture bottles limits the growth of S. moniliformis (8,11). Laboratory personnel should be consulted before processing of specimens when S. moniliformis is suspected.…”

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confidence: 99%

Prosthetic Valve Endocarditis Caused by Streptobacillus moniliformi s: a Case of Rat Bite Fever

Chen

Lee²,

Yan³

et al. 2007

J Clin Microbiol

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We report a case of rat bite fever caused by Streptobacillus moniliformis in Taiwan. It manifested as prosthetic valve endocarditis, which was cured by cardiac valve replacement and antimicrobial therapy. The DNA sequence of the 16S rRNA gene of S. moniliformis was detected in valve specimens by PCR and nucleotide sequencing. CASE REPORTA 60-year-old female was admitted to a university hospital in Tainan in southern Taiwan with a 2-week history of intermittent fever. Symptoms began 1 week later, after a rodent bite over her right big toe in her house in early October 2006. Pus was noted initially, and the wound healed subsequently. Associated symptoms were general weakness and body weight loss. She had received mechanical valve replacement for the rheumatic mitral valve 17 years ago. She was regularly followed up in a cardiac surgical clinic and took coumadin and trichloremthiazide regularly.On admission, her temperature was 38.1°C, her heart rate 82 beats/min, and her respiratory rate 18 breaths/min. Her blood pressure was 139/69 mm Hg. Physical examinations showed no skin lesions or joint inflammation. The heart sound of the mitral mechanical valve was clear, but a new grade 3/6 systolic murmur over the left lower sternum border radiating to the left apex was noted on cardiac auscultation. Laboratory studies revealed the following: leukocyte count, 15,100/mm 3 ; neutrophil level, 94%; lymphocyte level, 4%; hemoglobin level, 8.2 g/dl; and platelet count, 134,000/mm 3 . Electrolyte levels and renal and liver functions were normal. The serum level of C-reactive protein was 162.9 mg/liter (the normal level is Ͻ8 mg/liter) and the erythrocyte sedimentation rate 14 mm/h (the normal level is Ͻ15 mm/h). Transesophageal echocardiography revealed a dehiscence of the mechanical mitral valve, with severe posterior eccentric mitral regurgitation, and a fluttering mass with a size of 0.8 cm located at the lateral mitral valve annulus. She received mitral valve replacement for valve dysfunction on the 7th hospital day and became afebrile after the operation. Endocarditis with vegetations was confirmed by pathological examinations.

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Streptobacillus Moniliformis Isolated From Blood in Four Cases of Haverhill Fever

Cited by 44 publications

References 4 publications

Rat Bite Fever andStreptobacillus moniliformis

Rat Bite Fever andStreptobacillus moniliformis

Numerical analysis of electrophoretic protein patterns of Streptobacillus moniliformis strains from human, murine and avian infections

Prosthetic Valve Endocarditis Caused by Streptobacillus moniliformi s: a Case of Rat Bite Fever

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