Streptavidin-conjugated gold nanoclusters as ultrasensitive fluorescent sensors for early diagnosis of HIV infection

Kurdekar, Aditya; Chunduri, L. A. Avinash; Manohar, Chelli Sai; Haleyurgirisetty, Mohan; Hewlett, Indira; Venkataramaniah, K.

doi:10.1126/sciadv.aar6280

Cited by 66 publications

(55 citation statements)

References 33 publications

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“…Kurdekar et al developed a fluorescent gold nanocluster immunoassay (AuNCIA) for early and sensitive detection of human immune deficiency virus (HIV) infection in vitro and HIV-infected patient samples [85]. For this study, glutathionecapped AuNCs were coupled with streptavidin (Au-SA) using EDS/NHS coupling.…”

Section: Biosensing and Imaging Of Pathogensmentioning

confidence: 99%

Luminescent gold nanoclusters for bioimaging applications

Nonappa¹

2020

Beilstein J. Nanotechnol.

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Luminescent nanomaterials have emerged as attractive candidates for sensing, catalysis and bioimaging applications in recent years. For practical use in bioimaging, nanomaterials with high photoluminescence, quantum yield, photostability and large Stokes shifts are needed. While offering high photoluminescence and quantum yield, semiconductor quantum dots suffer from toxicity and are susceptible to oxidation. In this context, atomically precise gold nanoclusters protected by thiol monolayers have emerged as a new class of luminescent nanomaterials. Low toxicity, bioavailability, photostability as well as tunable size, composition, and optoelectronic properties make them suitable for bioimaging and biosensing applications. In this review, an overview of the sensing of pathogens, and of in vitro and in vivo bioimaging using luminescent gold nanoclusters along with the limitations with selected examples are discussed.

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Section: Biosensing and Imaging Of Pathogensmentioning

confidence: 99%

Luminescent gold nanoclusters for bioimaging applications

Nonappa¹

2020

Beilstein J. Nanotechnol.

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“…For example, SPR disappears when the size goes down below 2 nm due to quantum confinement effect and quantization of the conduction band (7). Unlike the conventional, plasmonic gold nanoparticles of facecentered cubic structure, the ultrasmall gold nanoparticles (socalled nanoclusters) with discrete energy levels exhibit unique geometrical (8)(9)(10) and electronic structures (11)(12)(13), and novel properties for applications in biomedicine (14,15), optoelectronics (16,17), and catalysis (18,19).…”

mentioning

confidence: 99%

Anomalous phonon relaxation in Au ₃₃₃ (SR) ₇₉ nanoparticles with nascent plasmons

Higaki

Zhou

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Research on plasmons of gold nanoparticles has gained broad interest in nanoscience. However, ultrasmall sizes near the metal-to-nonmetal transition regime have not been explored until recently due to major synthetic difficulties. Herein, intriguing electron dynamics in this size regime is observed in atomically precise Au333(SR)79 nanoparticles. Femtosecond transient-absorption spectroscopy reveals an unprecedented relaxation process of 4–5 ps—a fast phonon–phonon relaxation process, together with electron–phonon coupling (∼1 ps) and normal phonon–phonon coupling (>100 ps) processes. Three types of –R capped Au333(SR)79 all exhibit two plasmon-bleaching signals independent of the –R group as well as solvent, indicating plasmon splitting and quantum effect in the ultrasmall core of Au333(SR)79. This work is expected to stimulate future work on the transition-size regime of nanometals and discovery of behavior of nascent plasmons.

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“…The synthesis of highly stable polynuclear metal clusters is an important goal owing to their unique structures and versatile applications in optoelectronics, luminescence sensing, solar‐energy harvesting, and other areas . Many impressive metal clusters have been reported, with cores such as [Ti 20 ], [Au 32 ] 8+ , [Fe 42 ], [Cu 53 ], [Ag 374 ], [Gd 140 ], and [Ni 21 Gd 20 ], as well as [As@Ni 12 @As 20 ] 3− and inorganic fullerene‐like molecules .…”

Section: Introductionmentioning

confidence: 99%

An Ultrastable Matryoshka [Hf₁₃] Nanocluster as a Luminescent Sensor for Concentrated Alkali and Acid

Kang

et al. 2019

Angew Chem Int Ed

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Stable metal clusters that can resist both highly concentrated acid and alkali are unknown. Herein, we present a discrete neutral cluster, Hf13(μ4‐O)8(OCH3)36 (1), which features extraordinary chemical stability by preserving its crystalline state in concentrated aqueous solutions of both acid (10 m HNO3) and alkali (20 m boiling NaOH). Importantly, 1 can serve as a luminescent probe for detecting both concentrated alkali (20 m NaOH) and strong acid (1 m HNO3) with high selectivity and repeatability. DFT studies of the electronic structure and bonding revealed that 1 has an extremely large HOMO–LUMO gap due to strong d π–p π bonding that accounts for the ultrahigh stability.

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Streptavidin-conjugated gold nanoclusters as ultrasensitive fluorescent sensors for early diagnosis of HIV infection

Abstract: GNCIA allows a sensitive and selective detection of HIV-1 infections with a sensitivity of 5 pg/ml.

Cited by 66 publications

References 33 publications

Luminescent gold nanoclusters for bioimaging applications

Luminescent gold nanoclusters for bioimaging applications

Anomalous phonon relaxation in Au ₃₃₃ (SR) ₇₉ nanoparticles with nascent plasmons

An Ultrastable Matryoshka [Hf₁₃] Nanocluster as a Luminescent Sensor for Concentrated Alkali and Acid

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Streptavidin-conjugated gold nanoclusters as ultrasensitive fluorescent sensors for early diagnosis of HIV infection

Abstract: GNCIA allows a sensitive and selective detection of HIV-1 infections with a sensitivity of 5 pg/ml.

Cited by 66 publications

References 33 publications

Luminescent gold nanoclusters for bioimaging applications

Luminescent gold nanoclusters for bioimaging applications

Anomalous phonon relaxation in Au 333 (SR) 79 nanoparticles with nascent plasmons

An Ultrastable Matryoshka [Hf13] Nanocluster as a Luminescent Sensor for Concentrated Alkali and Acid

Contact Info

Product

Resources

About

Anomalous phonon relaxation in Au ₃₃₃ (SR) ₇₉ nanoparticles with nascent plasmons

An Ultrastable Matryoshka [Hf₁₃] Nanocluster as a Luminescent Sensor for Concentrated Alkali and Acid