Strenuous exercise, plasma fibrinogen, and factor VII activity.

Connelly, J B; Cooper, Jane; Meade, T W

doi:10.1136/hrt.67.5.351

Cited by 79 publications

(43 citation statements)

References 24 publications

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“…Fibrinogen concentration is elevated by a number of factors, including cigarette smoking, age, abdominal obesity and inactivity. 26,44 Although no relationship between fibrinogen and exercise was observed in the present study, a larger comparison of 3967 men aged 45-69 y found lower fibrinogen levels in those reporting strenuous exercise than in those reporting mild exercise after adjustment for differences in age, smoking and BMI. 44 In a study of 4057 middle-aged men, fibrinogen concentration was lower in normal-weight individuals who were fit than in normalweight individuals who were unfit.…”

Section: Exercise Waist Girth and Cvd Risk Factors G O'donovan Et Almentioning

confidence: 37%

“…26,44 Although no relationship between fibrinogen and exercise was observed in the present study, a larger comparison of 3967 men aged 45-69 y found lower fibrinogen levels in those reporting strenuous exercise than in those reporting mild exercise after adjustment for differences in age, smoking and BMI. 44 In a study of 4057 middle-aged men, fibrinogen concentration was lower in normal-weight individuals who were fit than in normalweight individuals who were unfit. 45 In the present study, there was a trend for blood pressure to increase across subgroups, with significant differences in diastolic pressure apparent between lean exercisers and obese sedentary men.…”

Section: Exercise Waist Girth and Cvd Risk Factors G O'donovan Et Almentioning

confidence: 37%

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Cardiovascular disease risk factors in habitual exercisers, lean sedentary men and abdominally obese sedentary men

et al. 2005

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OBJECTIVE:To investigate whether the favourable cardiovascular disease (CVD) risk factor profile of habitual exercisers is attributable to exercise or leanness. DESIGN: Cross-sectional study of 113 nonsmoking men aged 30-45 y. CVD risk factors were compared in exercisers (n ¼ 39) and sedentary men (n ¼ 74), and in subgroups of lean exercisers (n ¼ 37), lean sedentary men (n ¼ 46) and obese sedentary men (n ¼ 28). Waist girth was used to identify lean (o100 cm) and abdominally obese (Z100 cm) subgroups. MEASUREMENTS: Blood pressure, physical activity (7-day recall), physical fitness (maximum oxygen consumption) and fasted lipoproteins, apolipoprotein (apo) B, triglycerides, glucose and fibrinogen. RESULTS: Exercisers were fitter and leaner than sedentary men and had a better CVD risk factor profile. Total cholesterol, LDLcholesterol and apo B concentrations were lower in lean exercisers than in lean sedentary men, suggesting that exercise influences these risk factors. Indeed, time spent in vigorous activity was the only significant predictor of total cholesterol and LDL-cholesterol in multiple linear regression models. Exercise status had little influence on triglycerides and HDL-cholesterol (HDL-C), and unfavourable levels were only evident among obese sedentary men. Waist girth was the sole predictor of triglycerides and HDL-C, explaining 44 and 31% of the variance, respectively. CONCLUSIONS: These findings suggest that the CVD risk factor profile of habitual exercisers is attributable to leanness and exercise. Leanness is associated with favourable levels of HDL-C and triglycerides, while exercise is associated with lower levels of total cholesterol, LDL-cholesterol and apo B.

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Section: Exercise Waist Girth and Cvd Risk Factors G O'donovan Et Almentioning

confidence: 37%

Section: Exercise Waist Girth and Cvd Risk Factors G O'donovan Et Almentioning

confidence: 37%

Cardiovascular disease risk factors in habitual exercisers, lean sedentary men and abdominally obese sedentary men

et al. 2005

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“…Only few reports on the effects of physical exercise on FVII are available, and it seems that at least moderate exercise has no significant influence on FVII level [15][16][17] or the effect is at the most only relatively short-lived 18 . Dietary fat intake associates positively with FVIIc both in the fasting and postprandial states [19][20][21][22][23][24][25] .…”

Section: Coagulation Factor VIImentioning

confidence: 99%

Interaction of physical activity and diet: implications for haemostatic factors

Rauramaa

Väisänen²

1999

Public Health Nutr.

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Regular moderate intensity physical activity and habitual diet providing no more than one third of energy from fats have been recommended for the prevention of atherosclerotic diseases. The background for these guidelines is the key role of plasma lipids. However, the importance of thrombogenesis in acute myocardial infarction has become obvious during the last decade. Hyperlipidaemia and excess of adipose tissue increase platelet aggregability and blood coagulation, and decrease fibrinolysis. Both regular physical activity and dietary fat reduction decrease blood lipids and body fat thereby diminishing the risk of thrombosis. Currently, data on interactions between physical activity and diet on haemostasis are scarce, and the few studies available have not demonstrated additional effects when these two lifestyle modifications have been combined. This paper is restricted only to studies using controlled randomized design. Regular moderate intensity physical activity as well as diet rich in omega-3 fatty acids decrease platelet aggregability. The effects of regular physical activity on plasma fibrinogen remain contradictory, while the impact of diet is even less clear. Plasminogen activator inhibitor-1, a possible link between insulin resistance syndrome and coronary heart disease, may decrease due to physical training or low fat diet. It can be hypothesized that moderation in physical activity and diet carries a more powerful impact on blood coagulation and fibrinolysis than either lifestyle modification alone. Studies focusing on the interactions of regular moderate physical activity and fat-modified diet are needed in efforts to optimize the preventive actions by lifestyle changes.

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“…Connely et al conducted a cross sectional survey of 3,967 male participants and found that strenuous exercise, which included jogging, cycling, and fast swimming lowered fibrinogen levels [26].…”

Section: Interventionmentioning

confidence: 99%

“…Exercise: Data in a few studies on exercise and fibrinogen levels have shown that mild to moderate exercise can lower fibrinogen levels [26][27][28][29].…”

Section: Interventionmentioning

confidence: 99%

Natural Remedies Lower Elevated Fibrinogen Levels in the Prevention of Atherosclerosis

Narayan¹

2017

J Tradi Med Clin Natur

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Strenuous exercise, plasma fibrinogen, and factor VII activity.

Abstract: Objective-To assess the effect of physical activity on plasma fibrinogen and factor VII activity and thus on the risk of ischaemic heart disease.Design-Cross sectional survey.

Cited by 79 publications

References 24 publications

Cardiovascular disease risk factors in habitual exercisers, lean sedentary men and abdominally obese sedentary men

Cardiovascular disease risk factors in habitual exercisers, lean sedentary men and abdominally obese sedentary men

Interaction of physical activity and diet: implications for haemostatic factors

Natural Remedies Lower Elevated Fibrinogen Levels in the Prevention of Atherosclerosis

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