Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) in the International Journal of Medical Students

Gharaibeh, Aisha; Koppikar, Sahil; Bonilla‐Escobar, Francisco Javier

doi:10.5195/ijms.2014.76

Cited by 26 publications

(14 citation statements)

References 8 publications

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“…The overall mortality rate with pulmonary complications (17.2%) is higher than would be expected compared with prepandemic rates. [22][23][24][25][26][27]28 Data from elective and emergency surgical patients have shown high mortality associated with perioperative SARS-CoV-2 infection, which is consistent with our series. 5 This information should be used routinely as part of informed consent for elective surgery.…”

Section: Discussionsupporting

confidence: 89%

“…The study was conducted according to Strengthening the Reporting of Observational Studies in Epidemiology 25 and reported according to Statistical Analyses and Methods in the Published Literature. 26 Nonparametric data were summarized with medians and interquartile ranges, and differences between groups were tested using the Mann-Whitney U test.…”

Section: Discussionmentioning

confidence: 99%

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Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

Collaborative

2021

JCO

186

194

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PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

Collaborative

2021

JCO

186

194

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“…The study was analysed and reported according to STROBE methodology 20 and SAMPL. 21 Non-parametric data were summarised as medians and IQRs and differences between current pandemic cohort cases and historic cohort controls were analysed using the Mann-Whitney U test.…”

Section: Discussionmentioning

confidence: 99%

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study

Scheer

Walker

Kennedy

et al. 2021

The Lancet Gastroenterology & Hepatology

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“…The study was reported according to Strengthening the Reporting of Observational Studies in Epidemiology guidelines. 27 Proportions are expressed with 95% CIs, and the mean and 95% CIs were used where data were assumed to be approximately normally distributed. Fisher’s exact test was used for categorical data.…”

Section: Methodsmentioning

confidence: 99%

Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study

Collaborative¹

2021

BMJ Open

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ObjectivesStudies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644

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Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) in the International Journal of Medical Students

Abstract: NA

Cited by 26 publications

References 8 publications

Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study

Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study

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