Strength Training with Blood Flow Restriction Diminishes Myostatin Gene Expression

Laurentino, Gilberto; Ugrinowitsch, Carlos; Roschel, Hamilton; Aoki, Marcelo Saldanha; Soares, António; Neves, Manoel; Aihara, André Yui; Fernandes, Artur da Rocha Corrêa; Tricoli, Valmor

doi:10.1249/mss.0b013e318233b4bc

Cited by 359 publications

(417 citation statements)

References 30 publications

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“…Importantly, this accumulation of metabolites may increase muscle cell swelling [25], intramuscular anabolic/anti-catabolic signalling [9,26,27], and muscle fibre recruitment [4,28], which are all thought to be beneficial for muscular adaptation [23]. Furthermore, evidence suggests that the hypoxic environment created during BFR may increase the activation and proliferation of myogenic stem cells, enhancing the hypertrophic response [29].…”

Section: Adaptive Responses and Potential Mechanisms Underpinning Bfrmentioning

confidence: 99%

“…Laurentino et al [27] determined the pressure required for complete vascular restriction at the upper thigh during rest, and subsequently employed a BFR pressure of 80% arterial occlusive pressure during low-load resistance training. This training resulted in hypertrophic and strength responses similar to traditional high-load training.…”

Section: Restrictive Pressurementioning

confidence: 99%

“…It is important to understand that both the pressure and the width of the cuff employed during BFR operate in concert to provide the restrictive stimulus, and therefore neither should be considered as an independent indicator of the restrictive effects. Further research is needed before a comprehensive understanding is reached, though it appears that a BFR pressure equivalent to 50-80% of the pressure required to occlude arterial flow is appropriate during low-load resistance exercise [27,46].…”

Section: Restrictive Pressurementioning

confidence: 99%

“…Several investigations have reported significant muscular adaptations in both the arms [51,52] and legs [27,53] following single-joint training with BFR. However, evidence suggests that BFR resistance training with multi-joint exercise can also facilitate significant hypertrophy in muscles of the trunk [54][55][56].…”

Section: Type Of Exercisementioning

confidence: 99%

“…In a recent metaanalysis, low-load BFR resistance exercise was observed to have the largest effect on muscle hypertrophy and strength when intensities of 15-30% 1RM or MVC were used [59]. To illustrate, Laurentino et al [27] have demonstrated that 8 weeks of low-load knee extension training (twice per week using 3 sets of 15 repetitions) at 20% 1RM resulted in a large increase in knee extension 1RM (40.1%) in concert with a substantial increase in quadriceps CSA (6.3%). Similarly, Abe et al [54] reported that 2 weeks of BFR training (twice daily 6 days per week with 3 sets of 15 repetitions of squats and leg curls) using 20% 1RM resulted in large increases in squat and leg curl 1RM (17 and 23%, respectively), as well as considerable increases in quadriceps, biceps femoris and gluteus maximus muscle volume (7.7, 10.1 and 9.1%, respectively).…”

Section: Exercise Loadsmentioning

confidence: 99%

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Exercise with Blood Flow Restriction: An Updated Evidence-Based Approach for Enhanced Muscular Development

Scott¹,

Loenneke

Slattery³

et al. 2014

Sports Med

244

261

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Key Points• The blood flow restriction (BFR) stimulus should be individualized for each participant. In particular, consideration should be given to the restrictive pressure applied and cuff width used.• BFR elicits the largest increases in muscular development when combined with low-load resistance exercise, though some benefits may be seen using BFR alone during immobilization or combined with low-workload cardiovascular exercise.• For healthy individuals, training adaptations are likely maximized by combining low-load BFR resistance exercise with traditional high-load resistance exercise. 2 AbstractA growing body of evidence supports the use of moderate blood flow restriction (BFR) combined with low-load resistance exercise to enhance hypertrophic and strength responses in skeletal muscle. Research also suggests that BFR during lowworkload aerobic exercise can result in small but significant morphological and strength gains, and BFR alone may attenuate atrophy during periods of unloading.While BFR appears to be beneficial for both clinical and athletic cohorts, there is currently no common consensus amongst scientists and practitioners regarding the best practice for implementing BFR methods. If BFR is not employed appropriately, there is a risk of injury to the participant. It is also important to understand how variations in the cuff application can affect the physiological responses and subsequent adaptation to BFR training. The optimal way to manipulate acute exercise variables, such as exercise type, load, volume, inter-set rest periods and training frequency, must also be considered prior to designing a BFR training program. The purpose of this review is to provide an evidence-based approach to implementing BFR exercise. These guidelines could be useful for practitioners using BFR training in either clinical or athletic settings, or for researchers in the design of future studies investigating BFR exercise.3

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Section: Adaptive Responses and Potential Mechanisms Underpinning Bfrmentioning

confidence: 99%

Section: Restrictive Pressurementioning

confidence: 99%

Section: Restrictive Pressurementioning

confidence: 99%

Section: Type Of Exercisementioning

confidence: 99%

Section: Exercise Loadsmentioning

confidence: 99%

See 3 more Smart Citations

Exercise with Blood Flow Restriction: An Updated Evidence-Based Approach for Enhanced Muscular Development

Scott¹,

Loenneke

Slattery³

et al. 2014

Sports Med

244

261

View full text Add to dashboard Cite

show abstract

Low‐Load Resistance Training With Blood‐Flow Restriction in Relation to Muscle Function, Mass, and Functionality in Women With Rheumatoid Arthritis

Rodrigues

Ferraz

Kurimori

et al. 2020

Arthritis Care & Research

Self Cite

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Objective. To evaluate the effects of a low-load resistance training program associated with partial blood-flow restriction in patients with rheumatoid arthritis (RA).Methods. Forty-eight women with RA were randomized into 1 of 3 groups: high-load resistance training (HL-RT; 70% 1 repetition maximum [1RM]), low-load resistance training (30% 1RM) with partial blood-flow restriction training (BFRT), and a control group. Patients completed a 12-week supervised training program and were assessed for lower-extremity 1RM, quadriceps cross-sectional area (CSA), physical function (timed-stands test [TST], timedup-and-go test [TUG], and Health Assessment Questionnaire [HAQ]), and quality of life (Short Form 36 health survey ) at baseline and after the intervention.Results. BFRT and HL-RT were similarly effective in increasing maximum dynamic strength in both leg press (22.8% and 24.2%, respectively; P < 0.0001 for all) and knee extension (19.7% and 23.8%, respectively; P < 0.0001 for all). Quadriceps CSA was also significantly increased in both BFRT and HL-RT (9.5% and 10.8%, respectively; P < 0.0001 for all). Comparable improvements in TST (11.2% and 14.7%; P < 0.0001 for all) and TUG (-6.8% [P < 0.0053] and -8.7% [P < 0.0001]) were also observed in BFRT and HL-RT, respectively. Improvements in both groups were significantly greater than those of the control group (P < 0.05 for all). SF-36 role physical and bodily pain and HAQ scores were improved only in BFRT (45.7%,22.5%, and -55.9%, respectively; P < 0.05 for all). HL-RT resulted in 1 case of withdrawal and several cases of exercise-induced pain, which did not occur in BFRT.Conclusion. BFRT was effective in improving muscle strength, mass, function, and health-related quality of life in patients with RA, emerging as a viable therapeutic modality in RA management.Clinicaltrials.gov identifier: NCT01483157.

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Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake

Merz

Thurmond

2020

Comprehensive Physiology

208

114

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Strength Training with Blood Flow Restriction Diminishes Myostatin Gene Expression

Abstract: We concluded that LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression.

Cited by 359 publications

References 30 publications

Exercise with Blood Flow Restriction: An Updated Evidence-Based Approach for Enhanced Muscular Development

Exercise with Blood Flow Restriction: An Updated Evidence-Based Approach for Enhanced Muscular Development

Low‐Load Resistance Training With Blood‐Flow Restriction in Relation to Muscle Function, Mass, and Functionality in Women With Rheumatoid Arthritis

Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake

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