Strength Training Increases Insulin-Mediated Glucose Uptake, Glut4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes

Abstract

Strength training represents an alternative to endurance training for patients with type 2 diabetes. Little is known about the effect on insulin action and key proteins in skeletal muscle, and the necessary volume of strength training is unknown. A total of 10 type 2 diabetic subjects and 7 healthy men (control subjects) strength-trained one leg three times per week for 6 weeks while the other leg remained untrained. Each session lasted no more than 30 min. After strength training, muscle biopsies were obtained, and an isogly-cemic-hyperinsulinemic clamp combined with arterio-femoral venous catheterization of both legs was carried out. In general, qualitatively similar responses were obtained in both groups. During the clamp, leg blood flow was higher (P < 0.05) in trained versus untrained legs, but despite this, arterio-venous extraction glucose did not decrease in trained legs. Thus, leg glucose clearance was increased in trained legs (P < 0.05) and more than explained by increases in muscle mass. Strength training increased protein content of GLUT4, insulin receptor, protein kinase B-/, glycogen syn-thase (GS), and GS total activity. In conclusion, we found that strength training for 30 min three times per week increases insulin action in skeletal muscle in both groups. The adaptation is attributable to local contraction mediated mechanisms involving key proteins in the insulin signaling cascade. Diabetes 53:294-305, 2004

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss

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Efficiency of vibration exercise for glycemic control in type 2 diabetes patients

“…More recently, strength training also became an established treatment in that world-wide spreading metabolic disease 2,3,4,9. However, till today only a negligible amount of patients take advantage of any sport activity.…”

Does a GLP-1 receptor agonist change glucose tolerance in patients treated with antipsychotic medications? Design of a randomised, double-blinded, placebo-controlled clinical trial

“…Psychiatric patients on antipsychotic treatment, especially those who are overweight or obese, and/or have metabolic disturbances, are often encouraged to increase physical activity. Studies including patients with type 2 diabetes have shown that different types of exercise interventions with supervised training have positive effects on glycaemic control 8. Exercise improves the aerobic capacity and muscular strength, which is often related to fat loss, increased muscle mass, increased cardiovascular fitness and improved glycaemic control.…”

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