Strength of skeletal muscle and self-reported physical performance in Austrian glioblastoma-patients

Kéilani, Mohammad; Krall, Christoph; Marosi, Christine; Flechl, Birgit; Dieckmann, Karin; Widhalm, Georg; Marhold, Maximilian; Crevenna, Richard

doi:10.1007/s00508-012-0186-1

Cited by 19 publications

(6 citation statements)

References 29 publications

(72 reference statements)

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“…The reporting of functional performance in studies of patients with glioma has almost exclusively used subjective measures as the Karnofsky Performance Status scale, although this scale is limited with low specificity and sensitivity to reporting changes [13]. Only a few studies of limited data material have used clinical outcome measures to evaluate the functional performance of patients with primary glioma [14][15][16][17][18][19][20][21][22][23]. It has yet to be investigated if laterality impact patients objectively measured functional performance, which might implicate differentiated rehabilitation interventions.…”

Section: Introductionmentioning

confidence: 99%

Hemispheric tumor location and the impact on health-related quality of life, symptomatology, and functional performance outcomes in patients with glioma: an exploratory cross-sectional study

Hansen

Pedersen

Minet

et al. 2019

Disability and Rehabilitation

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To inform high-quality rehabilitation services, this study investigates if patients with glioma located in the right-or lefthemisphere present with different health-related quality of life, symptomatology, and functional performance in the early disease state. Material and methodsBetween 2013 and 2017, 81 adult patients were assessed during the first week of chemo-radiation, following resection.Patients were stratified into two groups depending on a right-or left-hemispheric lesion. Independent t-tests analyzed potential differences regarding health-related quality of life, symptomatology, and functional performance. ResultsForty-five patients (56%) had a tumor located in the right hemisphere, whereas 36 patients (44%) had a tumor in the left hemisphere. Except for more patients with tumors in the left hemisphere having their tumor located in eloquent brain areas, the groups were well matched. No group differences were found in health-related quality of life. Group differences were found in communication deficits (∆-10.9, 95%CI -19.1; -2.3, p=0.01), which were more frequent in patients with left-sided lesions, and of headaches (∆13.9, 95%CI 1.8; 25.9, p=0.02), which were more frequent in patients with right-hemispheric lesions, who also had significantly greater difficulties with process-skills when performing everyday life tasks (∆-0.3, 95%CI-0.5;-0.1, p<0.01). Also, weak evidence suggests that patients with Glioblastoma Multiforme located in the right hemisphere are more affected by fatigue compared to their lefthemispheric comparisons (∆14.6, 95%CI 0.19; 29.0, p<0.05). ConclusionsThe hemispheric location of a glial-cell brain tumor has no consequence for health-related quality of life at the beginning of chemo-radiation treatments. However, findings of tumor-location dependent conditions of communication, headache, patients' ability to perform executive functions, and fatigue should be considered in rehabilitation situations when designing an intervention to potentially improve executive functions and relieve the symptoms.

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Section: Introductionmentioning

confidence: 99%

Hemispheric tumor location and the impact on health-related quality of life, symptomatology, and functional performance outcomes in patients with glioma: an exploratory cross-sectional study

Hansen

Pedersen

Minet

et al. 2019

Disability and Rehabilitation

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“…This may be due to tumour-associated thrombosis or embolism involving one of the deep penetrating arteries [ 73 ]. Keilani et al (2012) reported that patients with glioblastoma experienced deficits in the muscular strength of thigh muscles, and their general physical performance was lower than expected [ 15 ]. The deficits persisted in the post-operative period, which may be due to the impact of the clinical course of glioblastoma on patients’ muscular strength [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have suggested that brain tumours can have a significant impact on the functional connectivity of the brain and that different brain networks are affected in different ways depending on the type and location of the tumour [ 4 , 5 , 8 , 9 , 15 ]. This systematic review aims to evaluate the effects of tumour invasion on the cognitive function of patients.…”

Section: Introductionmentioning

confidence: 99%

Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review

Sahrizan

Manan

Hamid

et al. 2023

Cancers

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Working memory, language and speech abilities, motor skills, and visual abilities are often impaired in children with brain tumours. This is because tumours can invade the brain’s functional areas and cause alterations to the neuronal networks. However, it is unclear what the mechanism of tumour invasion is and how various treatments can cause cognitive impairment. Therefore, this study aims to systematically evaluate the effects of tumour invasion on the cognitive, language, motor, and visual abilities of paediatric patients, as well as discuss the alterations and modifications in neuronal networks and anatomy. The electronic database, PubMed, was used to find relevant studies. The studies were systematically reviewed based on the type and location of brain tumours, cognitive assessment, and pre- and post-operative deficits experienced by patients. Sixteen studies were selected based on the inclusion and exclusion criteria following the guidelines from PRISMA. Most studies agree that tumour invasion in the brain causes cognitive dysfunction and alteration in patients. The effects of a tumour on cognition, language, motor, and visual abilities depend on the type of tumour and its location in the brain. The alteration to the neuronal networks is also dependent on the type and location of the tumour. However, the default mode network (DMN) is the most affected network, regardless of the tumour type and location.Furthermore, our findings suggest that different treatment types can also contribute to patients’ cognitive function to improve or deteriorate. Deficits that persisted or were acquired after surgery could result from surgical manipulation or the progression of the tumour’s growth. Meanwhile, recovery from the deficits indicated that the brain has the ability to recover and reorganise itself.

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“…Patients with GBM often receive high and extended doses of concomitant steroids that together with sedentary behaviour can affect clinical outcomes such as musculoskeletal atrophy, weakness, abnormalities in myofibrillar mass, mitochondrial volume, and capillary number, which may affect the ability to perform daily activities [28,29]. Decreased maximum muscle strength of knee extension has been observed in patients with gliomas to be lower than expected sex and age-matched comparisons [26,28]. Because resistance training is crucial to increasing muscle mass and preventing deterioration of functional performance it is indicated for patients with GBM.…”

Section: Resistance Trainingmentioning

confidence: 99%

“…However, performance status and age are among the best described prognostic factors in GBM, and most likely there is a strong relation between highperformance status and lower age [37]. Mean age in studies of patients with gliomas attending outpatient rehabilitation or physical capacity assessments ranges between 34 and 61 [7,26,28,38,39,40,41,42,43,44]. This implies that exercise rehabilitation intervention mainly addresses the younger population or patients with high Karnofsky performance status, which makes our case highly representative of this glioma population.…”

Section: Exercise Interventionmentioning

confidence: 99%

Development of an exercise intervention as part of rehabilitation in a glioblastoma multiforme survivor during irradiation treatment: a case report

Hansen

Søgaard

Minet

2018

Disability and Rehabilitation

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Based on this single case, exercise rehabilitation has the ability to maintain or improve functional performance and QOL domains even during heavy treatments. It also implies that patients with GBM are capable and may be willing to participate in exercise rehabilitation if supervised by physical therapists. Implications for rehabilitation The use of exercise as part of rehabilitation still needs attention in strong methodology studies of patients with gliomas. Exercise rehabilitation may maintain or even improve functional performance and QOL domains during medical treatment regimens. Functional independent patients with GBM are capable to comply with generic exercise recommendations and may be willing to participate in exercise rehabilitation if supervised by physical therapists.

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Strength of skeletal muscle and self-reported physical performance in Austrian glioblastoma-patients

Cited by 19 publications

References 29 publications

Hemispheric tumor location and the impact on health-related quality of life, symptomatology, and functional performance outcomes in patients with glioma: an exploratory cross-sectional study

Hemispheric tumor location and the impact on health-related quality of life, symptomatology, and functional performance outcomes in patients with glioma: an exploratory cross-sectional study

Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review

Development of an exercise intervention as part of rehabilitation in a glioblastoma multiforme survivor during irradiation treatment: a case report

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