Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects

Abstract

Objective: To evaluate the effects of the inhaled flunisolide upon the strength and endurance of the respiratory and peripheral muscles of normal subjects. Design: A randomized, double blind and placebo-controlled study. Setting: A university-affiliated teaching hospital. Participants: Thirteen normal volunteers selected from a graduation course. Intervention: Subjects were randomly allocated to receive a placebo or corticosteroid (flunisolide) to be inhaled twice a day for 4 weeks. After 2 weeks of a washout period, subjects who were receiving the placebo, received flunisolide and vise versa for another 4-week period. Measurements and results: Spirometry was used to define the volunteers as being normal in terms of pulmonary function. During the study, subjects performed tests of respiratory muscle function (strength and endurance), measurements of handgrip strength and endurance and anthropometric measurements. Muscle strength was measured each week while muscle endurance was measured every 2 weeks. There was no significant difference in the maximal inspiratory and expiratory pressure and handgrip strength during weeks 1-4 when the subjects used either flunisolide or placebo. However, we observed an increase in the endurance time of the respiratory and handgrip muscles in the 4th week of both flunisolide and placebo use, what may be considered due to a learning effect.

The Effects of Budesonid That Added to Tiotropium Therapy on Health Related Quality of Life, Exercise Capacity and Pulmonary Functions in COPD Patients

“…In patients with COPD, the effect of inhaled corticosteroids on respiratory muscle strength is unclear. However, in a study by Jardim et al (29), it was detected that the use of inhaled flunisolide in healthy individuals did not have an acute or clinical effect on peripheral or respiratory muscle strength. Similarly, the use of inhaled steroids was found to have no positive or negative effect on respiratory muscle strength in our study.…”

Glucocorticoids and physical performance: A systematic review with meta-analysis of randomized controlled trials

“…The studies included 147 subjects in crossover trials and 28 subjects in a parallel trial. Thirteen studies assessed the effect of glucocorticoids on maximal performance (19,(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34) and 3 studies assessed the effect of glucocorticoids on submaximal performance (14,35,36). For characteristics of the included studies see Table 1.…”

Sağlıklı Kişilerde Kavrama Kuvveti ile Öksürme Kuvveti Arasındaki İlişkinin İncelenmesi

“…18 Solunum problemine sahip hastalarda atelektaziyi tersine çevirme, etkin öksürme ve hava yolu hijyenini sağlama yeteneği MİB ile yakından ilişkilidir. [19][20][21] İnspiratuar ve ekspiratuar kas kuvvetini gösteren ağız içi basınçların, kavrama kuvveti de dahil olmak üzere periferal kas kuvveti ile ilişkili olduğu birçok çalışmada belirtilmiştir. [21][22][23][24] Genç ve orta yaşlı bireylerde yapılan çalışmalarda solunum sistemini değerlendirmeye yardımcı, basit bir değerlendirme yöntemi olan kavrama kuvvetinin, inspiratuar kas kuvvetini (özellikle diyafram kası) ve akciğer volümlerini indirekt olarak yansıttığı gösterilmiştir.…”