Strength and Balance Training for Adults With Peripheral Neuropathy and High Risk of Fall: Current Evidence and Implications for Future Research

Tofthagen, Cindy; Visovsky, Constance; Berry, Donna L.

doi:10.1188/12.onf.e416-e424

Cited by 95 publications

(83 citation statements)

References 32 publications

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“…However, many rehabilitation and training centers use lower intensities (Ex. 50% of the maximum voluntary capacity) to promote muscular strength gains, as most patients might present important co-morbidities which impossibilities then to train with higher loads 12,13 . Meanwhile, during rehabilitation/ training progression, the applicability of heavier training loads may induce a more robust strength gain and nerve plasticity.…”

Section: Introductionmentioning

confidence: 99%

Morphological Adjustments of the Radial Nerve Are Intensity-Dependent

Carbone

Neto

Gama

et al. 2017

Rev Bras Med Esporte

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Introduction: Peripheral nerve adaptation is critical for strength gains. However, information about intensity effects on nerve morphology is scarce. Objective: To compare the effects of different intensities of resistance training on radial nerve structures. Methods: Rats were divided into three groups: control (GC), training with 50% (GF1) and training 75% (GF2) of the animal's body weight. The morphological analysis of the nerve was done by light and transmission electron microscopy. One-way ANOVA and the Tukey's post hoc test were applied and the significance level was set at p≤0.05. Results: Training groups had an increase of strength compared to GC (p≤0.05). All measured nerve components (mean area and diameter of myelin fibers and axons, mean area and thickness of the myelin sheath, and of neurofilaments and microtubules) were higher in GF2 compared to the other (p≤0.05). Conclusion: Results demonstrated greater morphological changes on radial nerve after heavier loads. This can be important for rehabilitation therapies, training, and progression.

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Section: Introductionmentioning

confidence: 99%

Morphological Adjustments of the Radial Nerve Are Intensity-Dependent

Carbone

Neto

Gama

et al. 2017

Rev Bras Med Esporte

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“…It is estimated that of the 1.6 million new cancer diagnoses in 2013, 77% were individuals over the age of 55 (Alamgir, Muazzam, & Nasrullah, 2012). Cancer patients experiencing peripheral neuropathy have reported difficulties in walking and incidences of falls (Tofthagen, Visovsky, & Berry, 2012). In fact, it's estimated quantified that approximately 20% of patients with CIPN may fall, which is a higher percentage than age-matched controls (Mohile et al, 2009(Mohile et al, , 2011Tofthagen, Overcash, & Kip, 2012).…”

Section: Effects Of Cipn On Gait and Fall Risk 13mentioning

confidence: 99%

Effects of Chemotherapy-Induced-Peripheral-Neuropathy on Spatiotemporal Gait Parameters and Fall Risk in Cancer Patients After the Completion of Chemotherapy Drug Treatment

Marshall

Zipp²,

Battaglia³

et al. 2016

Archives of Physical Medicine and Rehabilitation

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“…Therefore, the occurrence of CIPN presents a diagnostic dilemma as, to date, approved, effective treatment options are lacking 46 . Research has focused on pharmacological therapies aimed to reduce PNP or treat selected side-effects [47][48][49] . While this has been helpful for neuropathic pain, it does not address the many other sensory and motor side-effects of PNP 47,[50][51][52] .…”

Section: Cognitive Functionmentioning

confidence: 99%

“…Research has focused on pharmacological therapies aimed to reduce PNP or treat selected side-effects [47][48][49] . While this has been helpful for neuropathic pain, it does not address the many other sensory and motor side-effects of PNP 47,[50][51][52] . On the contrary, many of these agents have been shown to have additional negative side-effects 26,53 .…”

Section: Cognitive Functionmentioning

confidence: 99%

Exercise, concomitant to therapy, has a positive influence on therapy-induced side-effects in patients with haematological malignancies

Streckmann¹

2014

JOSHA

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JOSHA is a service that helps scholars, researchers, and students descover, use, and build upon a wide range of content Exercise, concomitant to therapy, has a positive influence on therapyinduced side-effects in patients with haematological malignancies discussions. Special thanks also goes to Katja Zirlik, Christiane Guderian, Barbara Nuber and the team on ward Romberg for the many enlighting lunch breaks and skiing trips that were incredibly valuable during rougher times of work, but also for their academic support and advice. Furthermore, I am very grateful to the team of sport therapists, sport students and physiotherapists that worked on the training cite for oncological patients and supported me in the implementation of the exercise intervention. Especially to Svenja Simon-Hein, from whom I was able to learn a great deal. I also greatly appreciate the support of the research assistants, the recruiting doctors, the nurses, technical lab assistants as well as the IT support in the University Hospital of Freiburg as well as my colleagues in the University of Freiburg.A special thank you goes to all the patients who participated in the study and therefore made an essential contribution to this work as well as future research. ABSTRACTExercise interventions as a supportive measure in cancer therapy are becoming more and more relevant. With cancer therapy becoming more complex and effective, higher survival rates as well as longer life-spans are being achieved. Consequently, patients' quality of life is becoming increasingly important and the management of therapy-related side-effects therefore essential. An increasing amount of studies are demonstrating, that the previously propagated rest and immobility during cancer therapy is not only counterproductive but that exercise interventions hold enormous potential regarding the management of sideeffects in supportive cancer care and should therefore be taken more seriously.Especially haemato-oncological patients have to cope with many debilitating side-effects due to the disease itself, the long and complex medical therapy as well as the associated immobility. The symptoms cause physiological, psychological and social restraints, leading to acute as well as lasting reductions in patients' quality of life. Poor health and severe side-effects such as chemotherapy-induced peripheral neuropathy (CIPN) are highly relevant, as they can cause dose reductions, disruptions or discontinuation of medical therapy, consequently impacting the clinical outcome.Although the positive effects of exercise interventions are rather well documented in entities such as breast cancer, the amount of research in haematological patients, especially concomitant to therapy, is still relatively low. For instance only one previous randomized, controlled trial (RCT) 1 has evaluated lymphoma patients. Furthermore, the potential role of exercise regarding CIPN has never been investigated previously, although it is highly prevalent in haemato-oncological patients. Previous studies on patients wit...

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Strength and Balance Training for Adults With Peripheral Neuropathy and High Risk of Fall: Current Evidence and Implications for Future Research

Cited by 95 publications

References 32 publications

Morphological Adjustments of the Radial Nerve Are Intensity-Dependent

Morphological Adjustments of the Radial Nerve Are Intensity-Dependent

Effects of Chemotherapy-Induced-Peripheral-Neuropathy on Spatiotemporal Gait Parameters and Fall Risk in Cancer Patients After the Completion of Chemotherapy Drug Treatment

Exercise, concomitant to therapy, has a positive influence on therapy-induced side-effects in patients with haematological malignancies

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