sTREM-1 is a specific biomarker of TREM-1 pathway activation

Jolly, Lucie; Carrasco, Kévin; Salcedo-Magguilli, Margarita; Garaud, Jean–Jacques; Lambden, Simon; Poll, Tom van der; Mebazaa, Alexandre; Laterre, Pierre‐François; Gibot, Sébastien; Boufenzer, Amir; Derive, Marc

doi:10.1038/s41423-021-00733-5

Cited by 33 publications

(33 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the time of acute respiratory distress syndrome, we hypothesize sTREM-1 and TREM-1 reflect a distinct aspect of the innate immune response with greater contribution to age-related differences in ICU outcomes. A phase IIb trial testing the efficacy of a TREM-1 inhibitor among patients with septic shock is currently ongoing, and our work supports examining heterogeneity of treatment effect by age (19,38). Altogether, our findings corroborate the value of sTREM-1 as a marker of deleterious outcomes, and suggest that older adults comprise an important subgroup that could benefit from investigational immune-modulating therapies for critical illness.…”

Section: Discussionsupporting

confidence: 79%

“…Finally, our study focuses only on plasma measurements of sTREM-1 as a marker of TREM-1mediated inflammation, instead of direct measures of TREM-1 expression and activation, since such measurements are easier to translate into trials and clinical practice (19). It remains unclear which aspect of immune dysregulation downstream of TREM-1 contributes to poor outcomes, although we note sTREM-1 itself is unlikely to be a contributor; prior research suggests it may have a role as a decoy receptor to attenuate TREM-1's effects (14,19). Despite these limitations, we observed strong relationships we observed between older age and higher sTREM-1, as well as sTREM-1 and mortality and intend this work to be hypothesis-generating.…”

Section: Discussionmentioning

confidence: 99%

“…A soluble form of TREM-1 (sTREM-1) may reflect TREM-1 receptor activation and could help identify patients at high risk for related outcomes (19). Prior work demonstrates that sTREM-1 is strongly associated with death among adults with sepsis (19)(20)(21). However, its role outside of sepsis is understudied, and differences in sTREM-1 across age groups have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…Best studied in preclinical models of infection, blocking TREM-1 protects against the development of sepsis and shock while improving survival (12). A soluble form of TREM-1 (sTREM-1) may reflect TREM-1 receptor activation and could help identify patients at high risk for related outcomes (19). Prior work demonstrates that sTREM-1 is strongly associated with death among adults with sepsis (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Relationships Between Age, Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), and Mortality Among Critically Ill Adults: A Cohort Study

Sathe

Bhatraju

Mikacenic

et al. 2021

Shock

View full text Add to dashboard Cite

Background: Innate immune dysregulation may contribute to age-related differences in outcomes among critically ill adults. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is an important innate immune marker with prognostic value in sepsis, but age-related differences have not been studied. Methods: This was a prospective cohort from a large tertiary care hospital enrolling adults from both medical and trauma-surgical intensive care units (ICUs). Plasma sTREM-1 was measured in participants within 24 h of ICU admission. We analyzed associations between age ( 50 and >50 years) and sTREM-1 using linear regression. We then examined associations between sTREM-1 and both 28-day mortality and persistent organ dysfunction (defined as need for dialysis, vasopressors, or invasive mechanical ventilation) 7 days following admission using relative risk regression. Results: Of 231 critically ill adults, older patients (n ¼ 122) had higher prevalence of chronic disease and sepsis on enrollment than younger patients, but acute illness severity was similar. Age over 50 was associated with 27% higher sTREM-1 concentrations (95% CI 6%-53%), adjusted for sex and Charlson comorbidity index (CCI). Two-fold higher sTREM-1 was associated with 2.42-fold higher risk for mortality (95% CI 1.57, 3.73) and 1.86-fold higher risk for persistent organ dysfunction (95% CI 1.45, 2.39), adjusted for sex, CCI, and age. Conclusions: sTREM-1 was elevated among critically ill older adults, and strongly associated with both death and persistent organ dysfunction. Immune responses associated with sTREM-1 may contribute to age-related differences in ICU outcomes, warranting further study as a potential therapeutic target in older adults.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationships Between Age, Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), and Mortality Among Critically Ill Adults: A Cohort Study

Sathe

Bhatraju

Mikacenic

et al. 2021

Shock

View full text Add to dashboard Cite

show abstract

“…In some pathologies, overstimulation of these receptors can be associated with sepsis, arthritis, colitis and infections [ 16 , 17 ]. In addition, TLR4-dependent activation of TREM-1 recruits matrix metalloproteinase (MMP-9), which is able to induce sTREM-1 release [ 18 , 19 ]. Detection of sTREM-1 is considered a biomarker for infection and viral disease, including COVID-19 [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor

Sharapova

Ivanova

Романова

et al. 2022

IJMS

View full text Add to dashboard Cite

An investigation of innate immunity receptors sheds light on the mechanisms of inflammation and associated immune reactions. One of the key immune regulators is the TREM-1 receptor, which is involved in both inflammation and antitumor immune response. In this article, we have obtained a new ligand for the TREM-1 receptor. The peptide, named N3, is a part of the innate immune protein PGLYRP1/Tag7. It is responsible for activating the TREM-1 signaling pathway. Here, we have demonstrated that the N3 peptide acts like other TREM-1 receptor ligands: its binding results in a mild inflammation response and appearance of cytotoxic lymphocytes. We have shown that cytotoxic populations of lymphocytes in N3 peptide-treated PBMCs are similar to those treated with Tag7 or Hsp70. We also determined the part of the N3 peptide responsible for binding to TREM-1. The resulting peptide (N9) consists of nine amino acids and can be considered as a potential peptide that blocks TREM-1 signaling.

show abstract

Pyroptosis: the potential eye of the storm in adult-onset Still’s disease

You

Shi

et al. 2023

Inflammopharmacol

View full text Add to dashboard Cite

sTREM-1 is a specific biomarker of TREM-1 pathway activation

Cited by 33 publications

References 7 publications

Relationships Between Age, Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), and Mortality Among Critically Ill Adults: A Cohort Study

Relationships Between Age, Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), and Mortality Among Critically Ill Adults: A Cohort Study

N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor

Pyroptosis: the potential eye of the storm in adult-onset Still’s disease

Contact Info

Product

Resources

About