Cereal Chem. 94(3):369-376The by-product of rice milling (BRM), known as commercial rice bran, is the coproduct of rice processing. It is a mixture of outer layers of the grain, the embryo, and some of the starchy endosperm, and these are separated from brown rice to produce white, milled rice. This mixture contains a high concentration of protein (12-20%) in comparison with that of brown rice (7.1-8.3%) or white rice (6.3-7.1%) and is therefore an abundant and cheap protein source. Nearly 70% of the proteins in BRM are albumins and globulins, which are high in solubility, digestibility, and nutritional value. The BRM proteins are hypoallergenic and gluten-free. With these properties, this type protein has many advantages as a unique and valuable protein source in markets such as protein supplements. The BRM protein can be extracted by physical, alkali, and enzymatic methods, which give yields ranging from 13% to more than 90%. This review highlights the opportunities and challenges in processing of BRM protein as a food ingredient.