Strawberry Modulates LDL Oxidation and Postprandial Lipemia in Response to High-Fat Meal in Overweight Hyperlipidemic Men and Women

Burton‐Freeman, Britt; Linares, Amanda; Hyson, Dianne A.; Kappagoda, Tissa

doi:10.1080/07315724.2010.10719816

Cited by 136 publications

(164 citation statements)

References 20 publications

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Section: Discussioncontrasting

confidence: 99%

“…It is unclear why our results differ from the significant reductions in postprandial insulin (27,28), as well as triglycerides and oxidized LDL (26), found in the 2 previous postprandial strawberry studies. Dairy proteins and the timing of meal intake may diminish the effects of polyphenols (56,57); however, significant benefits have been achieved with the use of a milkbased beverage consumed with a test meal (26,28). Although the amount of strawberries required to optimize effects on clinical outcomes is unknown, our 40-g dose of freeze-dried powder was equivalent to w3 cups of fresh strawberries [13 g freeze-dried powder is equivalent to 1 cup fresh (C Christian California Strawberry Commission, personal communication, 2014)] and provided a substantial amount of polyphenols (Supplemental Table 2).…”

Section: Discussioncontrasting

confidence: 99%

“…Although the amount of strawberries required to optimize effects on clinical outcomes is unknown, our 40-g dose of freeze-dried powder was equivalent to w3 cups of fresh strawberries [13 g freeze-dried powder is equivalent to 1 cup fresh (C Christian California Strawberry Commission, personal communication, 2014)] and provided a substantial amount of polyphenols (Supplemental Table 2). A similar amount of total anthocyanins was provided in the postprandial study by Park et al (28), although the freeze-dried strawberry powder used by BurtonFreeman and colleagues (26,27) had a higher oxygen radical absorbance capacity value and a higher concentration of select polyphenolic compounds, including quercetin and pelargonidin-3-glucoside. These differences may account, in part, for the discrepancies between our results and those of Burton-Freeman et al (26).…”

Section: Discussionmentioning

confidence: 96%

“…A balanced randomization scheme with a block size of 6 was developed in advance (by ACS-R) with the use of an online randomization generator, and subjects were assigned to a treatment sequence at enrollment (by CKR). Sample size for this preliminary study was based on earlier studies of postprandial metabolic responses that reported a significant reduction in triglycerides with a similar polyphenol-rich intervention (8,26). No power calculation was performed for our primary outcome of postprandial vascular function because of the scarcity of published studies with the postprandial use of brachial pulse wave analysis to assess the effects of incorporating a polyphenolrich intervention into a meal.…”

Section: Participant Recruitmentmentioning

confidence: 99%

“…Longerterm strawberry supplementation has been shown to improve multiple CVD risk factors (16)(17)(18)(19)(20)(21)(22)(23)(24)(25), but less is known about the acute effects of strawberries in the context of a fat-containing meal. A modest attenuation of the 6-h postprandial triglyceride, insulin, and oxidized LDL response was found in overweight hyperlipidemic adults when 10 g freeze-dried strawberry powder was incorporated into a meal with 30 g total fat (26,27). In a subsequent study, incorporating 40 g freeze-dried strawberry powder into a high-carbohydrate meal with 25 g total fat significantly reduced the 6-h insulin response in individuals with insulin resistance, but had no effect on postprandial glucose, triglycerides, or oxidized LDL (28).…”

Section: Introductionmentioning

confidence: 97%

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Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: a randomized controlled trial

Richter

Skulas‐Ray

Gaugler

et al. 2017

The American Journal of Clinical Nutrition

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Background: Postprandial dysmetabolism-an exaggerated spike in triglycerides, glucose, and insulin-increases cardiovascular disease risk by inducing oxidative stress, inflammation, and endothelial dysfunction. Polyphenol-rich foods may blunt these effects when they are incorporated into a high-fat, calorie-dense meal. Strawberries are a rich source of polyphenols, but there is little research on their postprandial effects. Objective: This study was designed to investigate the effect of adding 40 g freeze-dried strawberry powder (w1 lb. or 0.45 kg fresh strawberries) to a high-fat (50 g total fat) meal on postprandial vascular function, as well as triglyceride, glucose, and insulin responses. Design: Healthy, overweight or obese [mean 6 SEM body mass index (in kg/m 2 ): 31 6 0.5] adults (mean 6 SEM age: 28 6 2 y; 17 men and 13 women) consumed a control meal and a strawberry meal in a randomized crossover design. Testing sessions were separated by $1 wk for men and w1 mo for women to control for hormonal variations. Blood samples were obtained before the meal and 0.5, 1, 2, and 4 h after the meal. Central blood pressure and arterial stiffness indexes were measured at baseline and 2 and 4 h postmeal with the use of pulse waveform analysis. Results: There were no significant differences between the strawberry and control meals for any outcomes. Consumption of either meal significantly decreased the augmentation index at 2 and 4 h (P , 0.002) and significantly increased triglycerides, insulin, and glucose at all time points (P , 0.001) relative to baseline. Conclusions: The strawberry intervention did not alter vascular function or attenuate postprandial metabolic derangements in triglycerides, glucose, or insulin relative to the control meal. Additional research is needed to clarify whether strawberries or other polyphenol-rich interventions improve postprandial responses, and future studies should take into account the acute meal-induced improvements in measures of vascular function. This trial was registered at clinicaltrials.gov as NCT01989637.Am J Clin Nutr 2017;105:313-22.

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